NENF | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	34 studies	41% ± 16%	Explore
smooth muscle cell	23 studies	38% ± 10%	Explore
pericyte	23 studies	35% ± 12%	Explore
macrophage	20 studies	29% ± 12%	Explore
endothelial cell	19 studies	29% ± 13%	Explore
basal cell	17 studies	35% ± 17%	Explore
connective tissue cell	16 studies	43% ± 18%	Explore
mast cell	14 studies	25% ± 5%	Explore
epithelial cell	14 studies	36% ± 20%	Explore
conventional dendritic cell	12 studies	28% ± 11%	Explore
myofibroblast cell	11 studies	42% ± 13%	Explore
capillary endothelial cell	10 studies	20% ± 4%	Explore
oligodendrocyte	10 studies	32% ± 16%	Explore
plasma cell	9 studies	35% ± 14%	Explore
plasmacytoid dendritic cell	9 studies	26% ± 8%	Explore
secretory cell	8 studies	36% ± 12%	Explore
endothelial cell of artery	8 studies	20% ± 4%	Explore
mesothelial cell	8 studies	39% ± 19%	Explore
abnormal cell	7 studies	37% ± 15%	Explore
myeloid cell	7 studies	28% ± 12%	Explore
ciliated cell	7 studies	33% ± 13%	Explore
endothelial cell of vascular tree	7 studies	26% ± 6%	Explore
club cell	6 studies	36% ± 12%	Explore
B cell	6 studies	20% ± 4%	Explore
goblet cell	6 studies	30% ± 14%	Explore
alveolar macrophage	5 studies	23% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	18% ± 2%	Explore
ionocyte	5 studies	29% ± 10%	Explore
classical monocyte	5 studies	23% ± 8%	Explore
non-classical monocyte	5 studies	25% ± 8%	Explore
platelet	5 studies	23% ± 5%	Explore
mononuclear phagocyte	5 studies	30% ± 18%	Explore
CD4-positive, alpha-beta T cell	5 studies	20% ± 3%	Explore
CD8-positive, alpha-beta T cell	5 studies	20% ± 5%	Explore
neuron	5 studies	35% ± 16%	Explore
enteroendocrine cell	5 studies	39% ± 21%	Explore
intestinal crypt stem cell	5 studies	30% ± 10%	Explore
vein endothelial cell	5 studies	24% ± 6%	Explore
transit amplifying cell	5 studies	27% ± 10%	Explore
dendritic cell	5 studies	35% ± 19%	Explore
type I pneumocyte	5 studies	28% ± 14%	Explore
oligodendrocyte precursor cell	5 studies	31% ± 16%	Explore
hematopoietic precursor cell	4 studies	39% ± 16%	Explore
respiratory goblet cell	4 studies	40% ± 21%	Explore
pancreatic A cell	4 studies	81% ± 8%	Explore
type B pancreatic cell	4 studies	69% ± 14%	Explore
epithelial cell of proximal tubule	4 studies	34% ± 7%	Explore
kidney loop of Henle epithelial cell	4 studies	27% ± 8%	Explore
astrocyte	4 studies	29% ± 16%	Explore
progenitor cell	4 studies	29% ± 6%	Explore
adventitial cell	4 studies	37% ± 13%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	44% ± 19%	Explore
T cell	3 studies	21% ± 4%	Explore
duct epithelial cell	3 studies	42% ± 10%	Explore
pancreatic D cell	3 studies	74% ± 13%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	20% ± 2%	Explore
glomerular endothelial cell	3 studies	19% ± 1%	Explore
leukocyte	3 studies	32% ± 8%	Explore
neural crest cell	3 studies	27% ± 3%	Explore
monocyte	3 studies	30% ± 9%	Explore
retinal ganglion cell	3 studies	68% ± 19%	Explore
placental villous trophoblast	3 studies	45% ± 22%	Explore
neuroendocrine cell	3 studies	59% ± 16%	Explore
amacrine cell	3 studies	36% ± 13%	Explore
retina horizontal cell	3 studies	39% ± 13%	Explore
microglial cell	3 studies	22% ± 7%	Explore
mucus secreting cell	3 studies	43% ± 13%	Explore
Mueller cell	3 studies	43% ± 9%	Explore
myoepithelial cell	3 studies	29% ± 8%	Explore
luminal cell of prostate epithelium	3 studies	44% ± 13%	Explore
endothelial cell of lymphatic vessel	3 studies	22% ± 5%	Explore
muscle cell	3 studies	39% ± 23%	Explore
pancreatic ductal cell	3 studies	45% ± 7%	Explore
granulocyte monocyte progenitor cell	3 studies	31% ± 9%	Explore
megakaryocyte	3 studies	34% ± 6%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	43% ± 22%	Explore
glial cell	3 studies	36% ± 18%	Explore
hepatocyte	3 studies	39% ± 26%	Explore
keratinocyte	3 studies	24% ± 3%	Explore
progenitor cell of mammary luminal epithelium	3 studies	33% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	13 studies	34% ± 14%	Explore
intestine	7 studies	31% ± 14%	Explore
brain	7 studies	29% ± 7%	Explore
eye	7 studies	24% ± 10%	Explore
peripheral blood	5 studies	23% ± 6%	Explore
kidney	5 studies	26% ± 9%	Explore
pancreas	4 studies	63% ± 18%	Explore
uterus	4 studies	38% ± 8%	Explore
breast	4 studies	33% ± 11%	Explore
liver	4 studies	29% ± 21%	Explore
placenta	3 studies	32% ± 13%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	4077.67	2642 / 2642	100%	183.09	705 / 705
liver	100%	1371.67	226 / 226	100%	167.76	406 / 406
skin	100%	2312.18	1809 / 1809	100%	244.07	472 / 472
thymus	100%	2726.31	653 / 653	100%	158.26	605 / 605
uterus	100%	3268.42	170 / 170	100%	196.56	459 / 459
prostate	100%	3274.81	245 / 245	100%	197.58	500 / 502
ovary	100%	3741.39	180 / 180	100%	152.25	428 / 430
esophagus	100%	2434.47	1445 / 1445	99%	91.67	182 / 183
pancreas	100%	1611.48	328 / 328	99%	158.62	177 / 178
breast	100%	2989.18	459 / 459	99%	229.09	1111 / 1118
stomach	100%	1701.91	359 / 359	99%	121.41	284 / 286
bladder	100%	2774.67	21 / 21	99%	169.51	500 / 504
lung	99%	2078.61	575 / 578	100%	158.71	1150 / 1155
intestine	100%	2092.12	966 / 966	99%	141.71	521 / 527
adrenal gland	100%	2206.84	258 / 258	99%	210.65	227 / 230
kidney	100%	2678.15	89 / 89	98%	139.40	880 / 901
adipose	100%	2767.59	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	375.96	80 / 80
heart	100%	3404.94	861 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	139.79	29 / 29
spleen	100%	1426.25	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	126.84	45 / 45
ureter	0%	0	0 / 0	100%	198.04	1 / 1
blood vessel	100%	3634.93	1334 / 1335	0%	0	0 / 0
muscle	100%	2464.75	801 / 803	0%	0	0 / 0
peripheral blood	45%	467.56	417 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0032099	Biological process	negative regulation of appetite
GO_0043410	Biological process	positive regulation of MAPK cascade
GO_0000165	Biological process	MAPK cascade
GO_0005615	Cellular component	extracellular space
GO_0012505	Cellular component	endomembrane system
GO_0005783	Cellular component	endoplasmic reticulum
GO_0016020	Cellular component	membrane
GO_0005739	Cellular component	mitochondrion
GO_0008083	Molecular function	growth factor activity
GO_0005515	Molecular function	protein binding
GO_0046872	Molecular function	metal ion binding

IV. Literature review

[source]

Gene name	NENF
Protein name	Neudesin (Cell immortalization-related protein 2) (Neuron-derived neurotrophic factor) (Protein GIG47) (Secreted protein of unknown function) (SPUF protein)
Synonyms	SPUF CIR2
Description	FUNCTION: Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival . Promotes cell proliferation and neurogenesis in undifferentiated neural progenitor cells at the embryonic stage and inhibits differentiation of astrocytes (By similarity). Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways (By similarity). Neurotrophic activity is enhanced by binding to heme (By similarity). Acts also as an anorexigenic neurotrophic factor that contributes to energy balance (By similarity). .
Accessions	ENST00000366988.5 Q9UMX5

NENF report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review