PAK3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
oligodendrocyte precursor cell	12 studies	32% ± 10%	Explore
glutamatergic neuron	11 studies	73% ± 18%	Explore
GABAergic neuron	10 studies	63% ± 24%	Explore
neuron	6 studies	45% ± 16%	Explore
interneuron	6 studies	71% ± 21%	Explore
retinal bipolar neuron	5 studies	32% ± 10%	Explore
pancreatic A cell	4 studies	51% ± 15%	Explore
Mueller cell	4 studies	25% ± 7%	Explore
pancreatic D cell	3 studies	53% ± 25%	Explore
type B pancreatic cell	3 studies	43% ± 8%	Explore
endothelial cell	3 studies	51% ± 21%	Explore
GABAergic interneuron	3 studies	74% ± 6%	Explore
astrocyte	3 studies	34% ± 15%	Explore
progenitor cell	3 studies	47% ± 14%	Explore
amacrine cell	3 studies	36% ± 10%	Explore
GABAergic amacrine cell	3 studies	33% ± 1%	Explore
OFF-bipolar cell	3 studies	38% ± 17%	Explore
ON-bipolar cell	3 studies	43% ± 14%	Explore
neural progenitor cell	3 studies	31% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	15 studies	44% ± 25%	Explore
pancreas	3 studies	44% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	83%	3253.60	2188 / 2642	92%	11.41	652 / 705
pancreas	100%	3479.02	328 / 328	67%	4.65	120 / 178
thymus	99%	3036.37	648 / 653	44%	1.63	267 / 605
prostate	82%	834.47	202 / 245	44%	0.85	222 / 502
adrenal gland	30%	282.46	78 / 258	67%	25.81	154 / 230
breast	67%	768.15	306 / 459	28%	0.75	317 / 1118
stomach	72%	569.87	259 / 359	15%	0.48	43 / 286
blood vessel	83%	765.61	1114 / 1335	0%	0	0 / 0
uterus	52%	349.16	88 / 170	18%	0.77	83 / 459
ovary	49%	316.66	89 / 180	13%	0.36	58 / 430
skin	44%	317.67	792 / 1809	12%	0.47	56 / 472
adipose	34%	206.40	407 / 1204	0%	0	0 / 0
kidney	6%	25.20	5 / 89	25%	0.54	221 / 901
esophagus	15%	99.00	221 / 1445	14%	0.47	25 / 183
lung	6%	26.56	33 / 578	21%	0.97	247 / 1155
tonsil	0%	0	0 / 0	24%	0.94	11 / 45
eye	0%	0	0 / 0	19%	0.66	15 / 80
intestine	7%	31.59	65 / 966	7%	0.41	39 / 527
bladder	5%	19.71	1 / 21	8%	0.43	42 / 504
liver	0%	0	0 / 226	10%	0.37	42 / 406
spleen	8%	38.52	20 / 241	0%	0	0 / 0
lymph node	0%	0	0 / 0	7%	0.08	2 / 29
muscle	0%	0.65	1 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
heart	0%	0	0 / 861	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0048013	Biological process	ephrin receptor signaling pathway
GO_0000165	Biological process	MAPK cascade
GO_0030833	Biological process	regulation of actin filament polymerization
GO_0060997	Biological process	dendritic spine morphogenesis
GO_0002223	Biological process	stimulatory C-type lectin receptor signaling pathway
GO_0007409	Biological process	axonogenesis
GO_0035556	Biological process	intracellular signal transduction
GO_0050770	Biological process	regulation of axonogenesis
GO_0006468	Biological process	protein phosphorylation
GO_0043408	Biological process	regulation of MAPK cascade
GO_0016358	Biological process	dendrite development
GO_0050808	Biological process	synapse organization
GO_0071407	Biological process	cellular response to organic cyclic compound
GO_0032956	Biological process	regulation of actin cytoskeleton organization
GO_0099175	Biological process	regulation of postsynapse organization
GO_0098978	Cellular component	glutamatergic synapse
GO_0005886	Cellular component	plasma membrane
GO_0005829	Cellular component	cytosol
GO_0014069	Cellular component	postsynaptic density
GO_0005737	Cellular component	cytoplasm
GO_0106310	Molecular function	protein serine kinase activity
GO_0004708	Molecular function	MAP kinase kinase activity
GO_0004674	Molecular function	protein serine/threonine kinase activity
GO_0031267	Molecular function	small GTPase binding
GO_0046872	Molecular function	metal ion binding
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding
GO_0017124	Molecular function	SH3 domain binding

IV. Literature review

[source]

Gene name	PAK3
Protein name	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (Beta-PAK) (Oligophrenin-3) (p21-activated kinase 3) (PAK-3)
Synonyms	OPHN3
Description	FUNCTION: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). .
Accessions	ENST00000518291.6 [O75914-3] ENST00000446737.5 [O75914-2] ENST00000372010.5 [O75914-1] ENST00000372007.10 [O75914-2] ENST00000417227.5 [O75914-4] ENST00000425146.5 [O75914-2] O75914 ENST00000262836.6 [O75914-1] ENST00000519681.5 [O75914-4] ENST00000360648.8 [O75914-3]

PAK3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review