Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 20 studies | 28% ± 9% | |
microglial cell | 11 studies | 31% ± 13% | |
classical monocyte | 10 studies | 26% ± 11% | |
macrophage | 10 studies | 33% ± 15% | |
myeloid cell | 7 studies | 26% ± 10% | |
non-classical monocyte | 6 studies | 29% ± 16% | |
glutamatergic neuron | 6 studies | 38% ± 24% | |
endothelial cell of lymphatic vessel | 6 studies | 34% ± 10% | |
oligodendrocyte | 6 studies | 24% ± 6% | |
monocyte | 5 studies | 29% ± 14% | |
fibroblast | 5 studies | 21% ± 4% | |
pericyte | 5 studies | 19% ± 5% | |
cardiac muscle cell | 4 studies | 19% ± 2% | |
dendritic cell | 4 studies | 29% ± 9% | |
GABAergic neuron | 4 studies | 41% ± 18% | |
astrocyte | 4 studies | 30% ± 11% | |
oligodendrocyte precursor cell | 4 studies | 27% ± 8% | |
mononuclear phagocyte | 3 studies | 20% ± 3% | |
endothelial cell of vascular tree | 3 studies | 30% ± 17% | |
type II pneumocyte | 3 studies | 19% ± 4% | |
lymphocyte | 3 studies | 23% ± 5% | |
smooth muscle cell | 3 studies | 17% ± 1% | |
interneuron | 3 studies | 37% ± 22% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 4523.18 | 1445 / 1445 | 100% | 16.48 | 183 / 183 |
skin | 100% | 3322.67 | 1808 / 1809 | 100% | 41.81 | 471 / 472 |
breast | 100% | 4914.00 | 459 / 459 | 100% | 22.35 | 1115 / 1118 |
prostate | 100% | 4628.79 | 245 / 245 | 100% | 22.86 | 500 / 502 |
lung | 100% | 5826.25 | 578 / 578 | 99% | 17.90 | 1147 / 1155 |
ovary | 100% | 4558.43 | 180 / 180 | 99% | 17.84 | 425 / 430 |
kidney | 100% | 3686.78 | 89 / 89 | 99% | 23.91 | 890 / 901 |
stomach | 100% | 3119.26 | 359 / 359 | 98% | 14.57 | 281 / 286 |
thymus | 100% | 3873.62 | 652 / 653 | 98% | 17.84 | 594 / 605 |
intestine | 100% | 4486.21 | 965 / 966 | 98% | 12.32 | 516 / 527 |
uterus | 100% | 5143.96 | 170 / 170 | 97% | 16.82 | 444 / 459 |
adrenal gland | 100% | 2374.20 | 258 / 258 | 96% | 20.34 | 221 / 230 |
bladder | 100% | 4502.05 | 21 / 21 | 95% | 13.63 | 479 / 504 |
brain | 93% | 1797.21 | 2461 / 2642 | 99% | 16.40 | 700 / 705 |
pancreas | 95% | 1484.13 | 310 / 328 | 98% | 18.63 | 174 / 178 |
liver | 96% | 1454.68 | 217 / 226 | 88% | 9.32 | 356 / 406 |
adipose | 100% | 5672.84 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 5697.45 | 1335 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 27.47 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 20.90 | 29 / 29 |
spleen | 100% | 7004.95 | 241 / 241 | 0% | 0 | 0 / 0 |
muscle | 100% | 2414.08 | 801 / 803 | 0% | 0 | 0 / 0 |
heart | 100% | 3959.51 | 858 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 99% | 8534.25 | 923 / 929 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 16.25 | 44 / 45 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0090050 | Biological process | positive regulation of cell migration involved in sprouting angiogenesis |
GO_2000773 | Biological process | negative regulation of cellular senescence |
GO_0071864 | Biological process | positive regulation of cell proliferation in bone marrow |
GO_0035556 | Biological process | intracellular signal transduction |
GO_0046777 | Biological process | protein autophosphorylation |
GO_0043123 | Biological process | positive regulation of canonical NF-kappaB signal transduction |
GO_0000165 | Biological process | MAPK cascade |
GO_1900745 | Biological process | positive regulation of p38MAPK cascade |
GO_0001568 | Biological process | blood vessel development |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0004709 | Molecular function | MAP kinase kinase kinase activity |
GO_0004674 | Molecular function | protein serine/threonine kinase activity |
GO_0106310 | Molecular function | protein serine kinase activity |
GO_0005515 | Molecular function | protein binding |
GO_0046872 | Molecular function | metal ion binding |
GO_0005524 | Molecular function | ATP binding |
GO_0004672 | Molecular function | protein kinase activity |
Gene name | MAP3K3 |
Protein name | Mitogen-activated protein kinase kinase kinase 3 variant 2 Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) Mitogen-activated protein kinase kinase kinase 3 |
Synonyms | MAPKKK3 MEKK3 |
Description | FUNCTION: Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. . |
Accessions | ENST00000584573.5 J3QS54 J3KRN4 Q99759 ENST00000577597.5 ENST00000579585.5 [Q99759-2] ENST00000585302.1 J3KTC4 ENST00000577395.5 J3QRB6 ENST00000361357.7 [Q99759-2] ENST00000581732.1 J3QS19 ENST00000361733.8 [Q99759-1] Q1PBM3 |