DUSP7 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DUSP7 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DUSP7 at tissue level.

III. Associated gene sets

GO_0043409Biological processnegative regulation of MAPK cascade
GO_0043407Biological processnegative regulation of MAP kinase activity
GO_0070371Biological processERK1 and ERK2 cascade
GO_0035335Biological processpeptidyl-tyrosine dephosphorylation
GO_0000165Biological processMAPK cascade
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0017017Molecular functionMAP kinase tyrosine/serine/threonine phosphatase activity
GO_0017018Molecular functionmyosin phosphatase activity
GO_0008330Molecular functionprotein tyrosine/threonine phosphatase activity
GO_0033550Molecular functionMAP kinase tyrosine phosphatase activity
GO_0005515Molecular functionprotein binding
GO_0008138Molecular functionprotein tyrosine/serine/threonine phosphatase activity
GO_0004725Molecular functionprotein tyrosine phosphatase activity

IV. Literature review

[source]
Gene nameDUSP7
Protein nameDual specificity protein phosphatase 7 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PYST2)
Dual specificity phosphatase 7
SynonymsPYST2
DescriptionFUNCTION: Dual specificity protein phosphatase . Shows high activity towards MAPK1/ERK2 . Also has lower activity towards MAPK14 and MAPK8 . In arrested oocytes, plays a role in meiotic resumption (By similarity). Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complex in oocytes, probably by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB (By similarity). May also inactivate PRKCA and/or PRKCG (By similarity). Also important in oocytes for normal chromosome alignment on the metaphase plate and progression to anaphase, where it might regulate activity of the spindle-assembly checkpoint (SAC) complex (By similarity). .

AccessionsENST00000469623.1
H7C4Z0
ENST00000495880.2 [Q16829-1]
Q16829