CAMKK2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1903599Biological processpositive regulation of autophagy of mitochondrion
GO_0045859Biological processregulation of protein kinase activity
GO_0034614Biological processcellular response to reactive oxygen species
GO_0061762Biological processCAMKK-AMPK signaling cascade
GO_0019722Biological processcalcium-mediated signaling
GO_0000165Biological processMAPK cascade
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006468Biological processprotein phosphorylation
GO_0046777Biological processprotein autophosphorylation
GO_0005654Cellular componentnucleoplasm
GO_0043005Cellular componentneuron projection
GO_0005829Cellular componentcytosol
GO_0106310Molecular functionprotein serine kinase activity
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0005524Molecular functionATP binding
GO_0004683Molecular functioncalmodulin-dependent protein kinase activity
GO_0005516Molecular functioncalmodulin binding
GO_0005509Molecular functioncalcium ion binding

IV. Literature review

[source]
Gene nameCAMKK2
Protein nameCalcium/calmodulin-dependent protein kinase kinase 2 (CaM-KK 2) (CaM-kinase kinase 2) (CaMKK 2) (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-KK beta) (CaM-kinase kinase beta) (CaMKK beta)
Calcium/calmodulin dependent protein kinase kinase 2
CAMKK beta protein
SynonymsCAMKKB
KIAA0787
DescriptionFUNCTION: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. .

AccessionsF5GZ00
ENST00000324774.9 [Q96RR4-1]
ENST00000412367.6 [Q96RR4-3]
ENST00000538733.5 [Q96RR4-5]
Q96RR4
Q8IZW1
ENST00000652382.1 [Q96RR4-1]
ENST00000543477.1
ENST00000404169.8 [Q96RR4-1]
ENST00000446440.6 [Q96RR4-6]
ENST00000392474.6 [Q96RR4-7]
ENST00000392473.2 [Q96RR4-2]
F5H360
F5H4I7
ENST00000347034.6 [Q96RR4-4]
ENST00000544485.1
ENST00000402834.8 [Q96RR4-1]
ENST00000545538.5
ENST00000337174.7 [Q96RR4-3]