MEF2C | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	50 studies	51% ± 17%	Explore
B cell	47 studies	53% ± 14%	Explore
pericyte	37 studies	52% ± 19%	Explore
macrophage	34 studies	50% ± 23%	Explore
smooth muscle cell	25 studies	42% ± 15%	Explore
conventional dendritic cell	24 studies	43% ± 19%	Explore
endothelial cell of lymphatic vessel	23 studies	43% ± 14%	Explore
non-classical monocyte	22 studies	34% ± 9%	Explore
classical monocyte	22 studies	31% ± 9%	Explore
plasma cell	21 studies	45% ± 13%	Explore
monocyte	20 studies	37% ± 19%	Explore
memory B cell	20 studies	54% ± 9%	Explore
naive B cell	20 studies	59% ± 13%	Explore
dendritic cell	19 studies	45% ± 16%	Explore
plasmacytoid dendritic cell	19 studies	55% ± 13%	Explore
microglial cell	18 studies	78% ± 17%	Explore
capillary endothelial cell	17 studies	41% ± 17%	Explore
endothelial cell of artery	15 studies	37% ± 15%	Explore
vein endothelial cell	14 studies	46% ± 21%	Explore
endothelial cell of vascular tree	14 studies	40% ± 19%	Explore
oligodendrocyte precursor cell	11 studies	31% ± 10%	Explore
glutamatergic neuron	11 studies	75% ± 25%	Explore
myeloid cell	11 studies	48% ± 23%	Explore
GABAergic neuron	10 studies	63% ± 31%	Explore
astrocyte	10 studies	40% ± 16%	Explore
plasmablast	9 studies	54% ± 21%	Explore
retinal cone cell	8 studies	59% ± 20%	Explore
mononuclear phagocyte	7 studies	36% ± 15%	Explore
retinal rod cell	7 studies	43% ± 15%	Explore
myofibroblast cell	6 studies	42% ± 23%	Explore
IgA plasma cell	6 studies	36% ± 12%	Explore
type II pneumocyte	6 studies	32% ± 6%	Explore
fibroblast	6 studies	32% ± 16%	Explore
neuron	5 studies	43% ± 22%	Explore
leukocyte	5 studies	48% ± 26%	Explore
IgG plasma cell	5 studies	38% ± 8%	Explore
hematopoietic stem cell	5 studies	34% ± 19%	Explore
pro-B cell	5 studies	53% ± 8%	Explore
immature B cell	5 studies	49% ± 16%	Explore
adipocyte	5 studies	23% ± 6%	Explore
cardiac muscle cell	5 studies	41% ± 4%	Explore
Mueller cell	5 studies	28% ± 6%	Explore
connective tissue cell	5 studies	43% ± 13%	Explore
interneuron	5 studies	65% ± 28%	Explore
hematopoietic precursor cell	4 studies	31% ± 10%	Explore
endothelial cell of sinusoid	4 studies	38% ± 13%	Explore
glomerular endothelial cell	4 studies	43% ± 4%	Explore
neutrophil	4 studies	34% ± 12%	Explore
glial cell	4 studies	31% ± 15%	Explore
megakaryocyte	4 studies	47% ± 15%	Explore
precursor B cell	4 studies	42% ± 14%	Explore
germinal center B cell	4 studies	50% ± 20%	Explore
club cell	4 studies	21% ± 4%	Explore
platelet	3 studies	19% ± 3%	Explore
natural killer cell	3 studies	22% ± 5%	Explore
tissue-resident macrophage	3 studies	37% ± 13%	Explore
muscle cell	3 studies	45% ± 7%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	52% ± 6%	Explore
Schwann cell	3 studies	28% ± 14%	Explore
oligodendrocyte	3 studies	32% ± 22%	Explore
mesothelial cell	3 studies	43% ± 19%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	19 studies	47% ± 27%	Explore
peripheral blood	9 studies	25% ± 14%	Explore
lung	8 studies	24% ± 8%	Explore
eye	7 studies	34% ± 13%	Explore
heart	6 studies	33% ± 8%	Explore
lymph node	4 studies	26% ± 11%	Explore
adipose	4 studies	25% ± 3%	Explore
kidney	3 studies	20% ± 5%	Explore
bone marrow	3 studies	27% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	3556.07	652 / 653	95%	11.20	574 / 605
adrenal gland	100%	3521.52	258 / 258	90%	9.27	208 / 230
breast	100%	3952.38	459 / 459	90%	8.18	1007 / 1118
brain	88%	4986.18	2335 / 2642	100%	22.90	703 / 705
lung	99%	3043.98	575 / 578	75%	7.06	864 / 1155
prostate	96%	1879.33	234 / 245	70%	4.86	353 / 502
kidney	78%	1142.40	69 / 89	82%	16.94	739 / 901
ovary	100%	3629.93	180 / 180	52%	2.66	222 / 430
intestine	96%	2359.15	923 / 966	43%	3.05	229 / 527
bladder	100%	2644.38	21 / 21	37%	2.79	188 / 504
esophagus	73%	1622.26	1049 / 1445	62%	4.16	113 / 183
uterus	99%	3619.76	168 / 170	34%	4.12	157 / 459
skin	38%	540.28	696 / 1809	91%	14.78	428 / 472
stomach	49%	862.18	175 / 359	62%	5.46	177 / 286
adipose	100%	4717.69	1204 / 1204	0%	0	0 / 0
muscle	100%	15641.37	803 / 803	0%	0	0 / 0
spleen	100%	4202.46	241 / 241	0%	0	0 / 0
blood vessel	100%	6509.82	1334 / 1335	0%	0	0 / 0
heart	98%	2249.28	842 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	29.74	28 / 29
eye	0%	0	0 / 0	96%	14.00	77 / 80
pancreas	5%	57.28	17 / 328	85%	6.99	151 / 178
tonsil	0%	0	0 / 0	58%	4.14	26 / 45
liver	8%	93.23	19 / 226	38%	2.00	153 / 406
peripheral blood	44%	3650.61	406 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0071560	Biological process	cellular response to transforming growth factor beta stimulus
GO_0001974	Biological process	blood vessel remodeling
GO_0071498	Biological process	cellular response to fluid shear stress
GO_0001947	Biological process	heart looping
GO_1905563	Biological process	negative regulation of vascular endothelial cell proliferation
GO_0002062	Biological process	chondrocyte differentiation
GO_0014902	Biological process	myotube differentiation
GO_0001764	Biological process	neuron migration
GO_0003138	Biological process	primary heart field specification
GO_0007521	Biological process	muscle cell fate determination
GO_0043537	Biological process	negative regulation of blood vessel endothelial cell migration
GO_0006959	Biological process	humoral immune response
GO_0035984	Biological process	cellular response to trichostatin A
GO_0060998	Biological process	regulation of dendritic spine development
GO_0003185	Biological process	sinoatrial valve morphogenesis
GO_0014033	Biological process	neural crest cell differentiation
GO_0030279	Biological process	negative regulation of ossification
GO_0003151	Biological process	outflow tract morphogenesis
GO_0071466	Biological process	cellular response to xenobiotic stimulus
GO_0007519	Biological process	skeletal muscle tissue development
GO_0002931	Biological process	response to ischemia
GO_0000165	Biological process	MAPK cascade
GO_0010629	Biological process	negative regulation of gene expression
GO_0001649	Biological process	osteoblast differentiation
GO_0010628	Biological process	positive regulation of gene expression
GO_0045663	Biological process	positive regulation of myoblast differentiation
GO_2000987	Biological process	positive regulation of behavioral fear response
GO_0051966	Biological process	regulation of synaptic transmission, glutamatergic
GO_0001958	Biological process	endochondral ossification
GO_0071374	Biological process	cellular response to parathyroid hormone stimulus
GO_0045669	Biological process	positive regulation of osteoblast differentiation
GO_0046928	Biological process	regulation of neurotransmitter secretion
GO_0043523	Biological process	regulation of neuron apoptotic process
GO_0071277	Biological process	cellular response to calcium ion
GO_0010694	Biological process	positive regulation of alkaline phosphatase activity
GO_0048667	Biological process	cell morphogenesis involved in neuron differentiation
GO_0030182	Biological process	neuron differentiation
GO_0051963	Biological process	regulation of synapse assembly
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0001568	Biological process	blood vessel development
GO_0071222	Biological process	cellular response to lipopolysaccharide
GO_0030220	Biological process	platelet formation
GO_0007399	Biological process	nervous system development
GO_0072102	Biological process	glomerulus morphogenesis
GO_0060025	Biological process	regulation of synaptic activity
GO_0098989	Biological process	NMDA selective glutamate receptor signaling pathway
GO_0003211	Biological process	cardiac ventricle formation
GO_0061333	Biological process	renal tubule morphogenesis
GO_0060045	Biological process	positive regulation of cardiac muscle cell proliferation
GO_0002467	Biological process	germinal center formation
GO_0060079	Biological process	excitatory postsynaptic potential
GO_2001016	Biological process	positive regulation of skeletal muscle cell differentiation
GO_0050853	Biological process	B cell receptor signaling pathway
GO_0045652	Biological process	regulation of megakaryocyte differentiation
GO_0001782	Biological process	B cell homeostasis
GO_0048643	Biological process	positive regulation of skeletal muscle tissue development
GO_0098990	Biological process	AMPA selective glutamate receptor signaling pathway
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0048666	Biological process	neuron development
GO_0030890	Biological process	positive regulation of B cell proliferation
GO_0007517	Biological process	muscle organ development
GO_0042100	Biological process	B cell proliferation
GO_0043524	Biological process	negative regulation of neuron apoptotic process
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_2000111	Biological process	positive regulation of macrophage apoptotic process
GO_1904706	Biological process	negative regulation of vascular associated smooth muscle cell proliferation
GO_0007507	Biological process	heart development
GO_0007611	Biological process	learning or memory
GO_0002634	Biological process	regulation of germinal center formation
GO_2000727	Biological process	positive regulation of cardiac muscle cell differentiation
GO_0043410	Biological process	positive regulation of MAPK cascade
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0048167	Biological process	regulation of synaptic plasticity
GO_0030318	Biological process	melanocyte differentiation
GO_0072160	Biological process	nephron tubule epithelial cell differentiation
GO_0030154	Biological process	cell differentiation
GO_0051145	Biological process	smooth muscle cell differentiation
GO_0006915	Biological process	apoptotic process
GO_1904753	Biological process	negative regulation of vascular associated smooth muscle cell migration
GO_2001013	Biological process	epithelial cell proliferation involved in renal tubule morphogenesis
GO_0045666	Biological process	positive regulation of neuron differentiation
GO_0003139	Biological process	secondary heart field specification
GO_0030501	Biological process	positive regulation of bone mineralization
GO_0055012	Biological process	ventricular cardiac muscle cell differentiation
GO_0098794	Cellular component	postsynapse
GO_0005634	Cellular component	nucleus
GO_0005654	Cellular component	nucleoplasm
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0032991	Cellular component	protein-containing complex
GO_0005737	Cellular component	cytoplasm
GO_0000785	Cellular component	chromatin
GO_0016528	Cellular component	sarcoplasm
GO_0016607	Cellular component	nuclear speck
GO_0005829	Cellular component	cytosol
GO_0140297	Molecular function	DNA-binding transcription factor binding
GO_0001228	Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific
GO_0046982	Molecular function	protein heterodimerization activity
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0061629	Molecular function	RNA polymerase II-specific DNA-binding transcription factor binding
GO_0042826	Molecular function	histone deacetylase binding
GO_0000976	Molecular function	transcription cis-regulatory region binding
GO_0003680	Molecular function	minor groove of adenine-thymine-rich DNA binding
GO_0003700	Molecular function	DNA-binding transcription factor activity
GO_0005515	Molecular function	protein binding
GO_0000977	Molecular function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837	Molecular function	sequence-specific double-stranded DNA binding

IV. Literature review

[source]

Gene name	MEF2C
Protein name	Myocyte-specific enhancer factor 2C (Myocyte enhancer factor 2C) Myocyte enhancer factor 2C
Synonyms	hCG_36839
Description	FUNCTION: Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoforms that lack the repressor domain are more active than isoform 1. .
Accessions	D6RJG6 ENST00000625674.2 [Q06413-6] A0A0D9SFD0 ENST00000424173.6 [Q06413-6] ENST00000637481.1 D6RG14 ENST00000635898.1 ENST00000627717.2 ENST00000631026.2 ENST00000340208.9 [Q06413-5] ENST00000637732.1 [Q06413-3] D6R942 ENST00000629612.2 [Q06413-2] ENST00000514028.5 [Q06413-3] ENST00000437473.6 [Q06413-1] ENST00000510942.5 ENST00000502983.5 A0A9L9PYA3 ENST00000636294.1 [Q06413-1] A0A0R4J2G5 D6RC63 ENST00000502831.5 ENST00000513252.5 D6RCM6 ENST00000504921.7 [Q06413-1] ENST00000503075.1 ENST00000506554.5 D6RG21 D6RJA7 ENST00000509373.1 ENST00000707127.1 ENST00000508569.5 [Q06413-2] D6RJ95 ENST00000514015.5 [Q06413-3] ENST00000628656.2 [Q06413-4] A0A0D9SGF3 ENST00000506716.5 A0A0D9SG58 ENST00000507984.5 A0A1B0GVI4 ENST00000503554.4 ENST00000627170.2 A0A1B0GV32 ENST00000636998.1 [Q06413-3] Q06413 D6RB91 A0A0D9SFV9 ENST00000626391.2 ENST00000625585.2 A0A1B0GTW4 ENST00000636541.1 A0A0D9SET2 A0A0D9SGI5 ENST00000508610.5 D8L7E9 ENST00000627659.2

MEF2C report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review