USP17L2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of USP17L2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of USP17L2 at tissue level.

III. Associated gene sets

GO_0071108Biological processprotein K48-linked deubiquitination
GO_0034260Biological processnegative regulation of GTPase activity
GO_0010955Biological processnegative regulation of protein processing
GO_0043547Biological processpositive regulation of GTPase activity
GO_0000165Biological processMAPK cascade
GO_1900246Biological processpositive regulation of RIG-I signaling pathway
GO_0070536Biological processprotein K63-linked deubiquitination
GO_0042981Biological processregulation of apoptotic process
GO_0030334Biological processregulation of cell migration
GO_0090315Biological processnegative regulation of protein targeting to membrane
GO_1900245Biological processpositive regulation of MDA-5 signaling pathway
GO_0016579Biological processprotein deubiquitination
GO_0006915Biological processapoptotic process
GO_0110030Biological processregulation of G2/MI transition of meiotic cell cycle
GO_0050691Biological processregulation of defense response to virus by host
GO_0071586Biological processCAAX-box protein processing
GO_0042127Biological processregulation of cell population proliferation
GO_1900027Biological processregulation of ruffle assembly
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0004843Molecular functioncysteine-type deubiquitinase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameUSP17L2
Protein nameUbiquitin carboxyl-terminal hydrolase 17 (USP17) (EC 3.4.19.12) (Deubiquitinating enzyme 17-like protein 2) (Deubiquitinating protein 3) (DUB-3) (Ubiquitin carboxyl-terminal hydrolase 17-like protein 2) (Ubiquitin thioesterase 17-like protein 2) (Ubiquitin-specific-processing protease 17-like protein 2)
SynonymsUSP17K
USP17L
USP17I
USP17H
DUB3
USP17
USP17J
USP17M
DescriptionFUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetylation. Through activation of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration. Through the cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains of the cytoplasmic innate immune receptors RIGI and IFIH1 stimulates the cellular response to viral infection. .

AccessionsQ6R6M4
ENST00000333796.4