BRAP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0009968Biological processnegative regulation of signal transduction
GO_0016567Biological processprotein ubiquitination
GO_0007265Biological processRas protein signal transduction
GO_0000165Biological processMAPK cascade
GO_0000151Cellular componentubiquitin ligase complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0031965Cellular componentnuclear membrane
GO_0005737Cellular componentcytoplasm
GO_0008139Molecular functionnuclear localization sequence binding
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding
GO_0003676Molecular functionnucleic acid binding

IV. Literature review

[source]
Gene nameBRAP
Protein nameBRCA1 associated protein
BRCA1-associated protein (EC 2.3.2.27) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (RING-type E3 ubiquitin transferase BRAP2) (Renal carcinoma antigen NY-REN-63)
SynonymsRNF52
DescriptionFUNCTION: Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport. .

AccessionsENST00000327551.6
J3KNN7
Q7Z569
ENST00000419234.9 [Q7Z569-1]