PPP5C report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006470Biological processprotein dephosphorylation
GO_0043278Biological processresponse to morphine
GO_0000278Biological processmitotic cell cycle
GO_0000165Biological processMAPK cascade
GO_0006302Biological processdouble-strand break repair
GO_0010288Biological processresponse to lead ion
GO_0035970Biological processpeptidyl-threonine dephosphorylation
GO_1904550Biological processresponse to arachidonic acid
GO_0006351Biological processDNA-templated transcription
GO_0070262Biological processpeptidyl-serine dephosphorylation
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0005886Cellular componentplasma membrane
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0101031Cellular componentprotein folding chaperone complex
GO_0005829Cellular componentcytosol
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005634Cellular componentnucleus
GO_0043531Molecular functionADP binding
GO_0004721Molecular functionphosphoprotein phosphatase activity
GO_0008289Molecular functionlipid binding
GO_0017018Molecular functionmyosin phosphatase activity
GO_0051879Molecular functionHsp90 protein binding
GO_0042802Molecular functionidentical protein binding
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0004722Molecular functionprotein serine/threonine phosphatase activity
GO_0048156Molecular functiontau protein binding
GO_0016791Molecular functionphosphatase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePPP5C
Protein nameSerine/threonine-protein phosphatase 5 (PP5) (EC 3.1.3.16) (Protein phosphatase T) (PP-T) (PPT)
Serine/threonine-protein phosphatase (EC 3.1.3.16)
SynonymsPPP5
DescriptionFUNCTION: Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT . Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses . Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1 . Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress . Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function (By similarity). Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1 (By similarity). Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E . May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels . Dephosphorylates and may play a role in the regulation of TAU/MAPT . Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2 (By similarity). Dephosphorylate FNIP1, disrupting interaction with HSP90AA1/Hsp90 . .

AccessionsQ9BPW0
ENST00000391919.1
A8MU39
ENST00000012443.9
H0YDU8
P53041
ENST00000478046.5