MEF2A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046326Biological processpositive regulation of glucose import
GO_0000165Biological processMAPK cascade
GO_0007507Biological processheart development
GO_0010613Biological processpositive regulation of cardiac muscle hypertrophy
GO_0048813Biological processdendrite morphogenesis
GO_0010628Biological processpositive regulation of gene expression
GO_0048311Biological processmitochondrion distribution
GO_0055005Biological processventricular cardiac myofibril assembly
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0070375Biological processERK5 cascade
GO_0071277Biological processcellular response to calcium ion
GO_0006351Biological processDNA-templated transcription
GO_0030154Biological processcell differentiation
GO_0061337Biological processcardiac conduction
GO_0007517Biological processmuscle organ development
GO_0006915Biological processapoptotic process
GO_0000002Biological processmitochondrial genome maintenance
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0003682Molecular functionchromatin binding
GO_0019901Molecular functionprotein kinase binding
GO_0046332Molecular functionSMAD binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0035035Molecular functionhistone acetyltransferase binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameMEF2A
Protein nameMyocyte enhancer factor 2A isoform 5
MADS box transcription enhancer factor 2, polypeptide A (Myocyte enhancer factor 2A), isoform CRA_a (Myocyte enhancer factor 2A isoform 2)
MADS box transcription enhancer factor 2, polypeptide A (Myocyte enhancer factor 2A), isoform CRA_b (Myocyte enhancer factor 2A isoform 1)
MADS box transcription enhancer factor 2, polypeptide A (Myocyte enhancer factor 2A), isoform CRA_d (Myocyte enhancer factor 2A isoform 3)
Myocyte enhancer factor 2A isoform 4
Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1)
Alternative protein MEF2A
Myocyte enhancer factor 2A
SynonymshCG_1993173
MEF2
DescriptionFUNCTION: Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter. .

AccessionsQ02078
A0A8I5KPE6
ENST00000560493.5
ENST00000354410.9 [Q02078-5]
ENST00000558049.5
A0A0S2Z4N0
ENST00000691492.1 [Q02078-6]
A0A0S2Z453
A0A0S2Z454
H0YM62
H0YKY6
ENST00000449277.6 [Q02078-8]
ENST00000557785.5 [Q02078-6]
A0A0S2Z417
ENST00000558812.5 [Q02078-7]
ENST00000559903.1
ENST00000686611.1 [Q02078-1]
ENST00000705985.1
ENST00000690055.1
A0A0S2Z4C8
ENST00000557942.6 [Q02078-2]
A0A8I5KVQ4
L0R504
ENST00000685785.1
ENST00000338042.11
H0YNI2