Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 47 studies | 45% ± 18% | |
macrophage | 34 studies | 42% ± 21% | |
B cell | 31 studies | 29% ± 13% | |
fibroblast | 20 studies | 32% ± 13% | |
smooth muscle cell | 18 studies | 30% ± 12% | |
astrocyte | 18 studies | 36% ± 15% | |
microglial cell | 18 studies | 77% ± 17% | |
pericyte | 17 studies | 33% ± 13% | |
conventional dendritic cell | 16 studies | 28% ± 12% | |
classical monocyte | 15 studies | 22% ± 8% | |
oligodendrocyte | 15 studies | 41% ± 14% | |
capillary endothelial cell | 15 studies | 40% ± 13% | |
dendritic cell | 14 studies | 40% ± 22% | |
vein endothelial cell | 14 studies | 37% ± 21% | |
monocyte | 13 studies | 37% ± 20% | |
naive B cell | 13 studies | 22% ± 5% | |
endothelial cell of artery | 13 studies | 32% ± 12% | |
memory B cell | 13 studies | 22% ± 3% | |
glutamatergic neuron | 12 studies | 55% ± 25% | |
oligodendrocyte precursor cell | 12 studies | 39% ± 13% | |
myeloid cell | 12 studies | 45% ± 22% | |
endothelial cell of lymphatic vessel | 11 studies | 37% ± 15% | |
GABAergic neuron | 10 studies | 51% ± 20% | |
ciliated cell | 10 studies | 30% ± 16% | |
non-classical monocyte | 9 studies | 26% ± 9% | |
epithelial cell | 9 studies | 37% ± 20% | |
basal cell | 9 studies | 31% ± 21% | |
adipocyte | 9 studies | 40% ± 13% | |
endothelial cell of vascular tree | 9 studies | 34% ± 21% | |
plasmacytoid dendritic cell | 8 studies | 23% ± 8% | |
neuron | 7 studies | 43% ± 17% | |
mast cell | 7 studies | 28% ± 15% | |
interneuron | 6 studies | 55% ± 23% | |
retinal ganglion cell | 6 studies | 43% ± 15% | |
precursor B cell | 6 studies | 30% ± 7% | |
myofibroblast cell | 6 studies | 29% ± 16% | |
retinal cone cell | 6 studies | 29% ± 11% | |
cardiac muscle cell | 6 studies | 63% ± 21% | |
mesothelial cell | 6 studies | 33% ± 10% | |
connective tissue cell | 6 studies | 28% ± 10% | |
pro-B cell | 5 studies | 29% ± 5% | |
club cell | 5 studies | 29% ± 8% | |
amacrine cell | 5 studies | 34% ± 11% | |
mononuclear phagocyte | 5 studies | 36% ± 17% | |
retina horizontal cell | 5 studies | 24% ± 8% | |
leukocyte | 5 studies | 42% ± 27% | |
type I pneumocyte | 5 studies | 45% ± 9% | |
type II pneumocyte | 5 studies | 34% ± 7% | |
granule cell | 4 studies | 41% ± 5% | |
plasma cell | 4 studies | 45% ± 9% | |
retinal bipolar neuron | 4 studies | 24% ± 5% | |
lymphocyte | 4 studies | 32% ± 5% | |
Mueller cell | 4 studies | 31% ± 9% | |
OFF-bipolar cell | 4 studies | 23% ± 9% | |
ON-bipolar cell | 4 studies | 29% ± 7% | |
retinal rod cell | 4 studies | 34% ± 9% | |
T cell | 4 studies | 27% ± 7% | |
muscle cell | 4 studies | 31% ± 15% | |
neutrophil | 4 studies | 27% ± 15% | |
alveolar macrophage | 4 studies | 55% ± 20% | |
abnormal cell | 4 studies | 28% ± 19% | |
naive thymus-derived CD4-positive, alpha-beta T cell | 3 studies | 17% ± 1% | |
glomerular endothelial cell | 3 studies | 41% ± 1% | |
GABAergic interneuron | 3 studies | 46% ± 3% | |
glial cell | 3 studies | 28% ± 8% | |
progenitor cell | 3 studies | 32% ± 4% | |
immature B cell | 3 studies | 28% ± 8% | |
CD4-positive, alpha-beta T cell | 3 studies | 17% ± 2% | |
endocardial cell | 3 studies | 46% ± 15% | |
tissue-resident macrophage | 3 studies | 35% ± 20% | |
GABAergic amacrine cell | 3 studies | 40% ± 13% | |
glycinergic amacrine cell | 3 studies | 36% ± 9% | |
rod bipolar cell | 3 studies | 34% ± 10% | |
secretory cell | 3 studies | 27% ± 11% | |
hepatocyte | 3 studies | 68% ± 15% | |
ependymal cell | 3 studies | 44% ± 16% | |
natural killer cell | 3 studies | 24% ± 3% | |
respiratory goblet cell | 3 studies | 35% ± 10% | |
goblet cell | 3 studies | 36% ± 23% | |
kidney distal convoluted tubule epithelial cell | 3 studies | 42% ± 15% | |
kidney loop of Henle epithelial cell | 3 studies | 30% ± 12% | |
renal alpha-intercalated cell | 3 studies | 29% ± 12% | |
renal principal cell | 3 studies | 32% ± 11% | |
mucus secreting cell | 3 studies | 32% ± 5% | |
enteroendocrine cell | 3 studies | 20% ± 4% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 19 studies | 47% ± 19% | |
lung | 10 studies | 29% ± 12% | |
eye | 7 studies | 32% ± 16% | |
heart | 6 studies | 43% ± 18% | |
kidney | 5 studies | 30% ± 10% | |
adipose | 4 studies | 35% ± 12% | |
peripheral blood | 3 studies | 30% ± 11% | |
breast | 3 studies | 20% ± 2% | |
liver | 3 studies | 41% ± 19% | |
intestine | 3 studies | 19% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 3965.51 | 1442 / 1445 | 100% | 36.12 | 183 / 183 |
lung | 100% | 6361.98 | 578 / 578 | 100% | 24.71 | 1151 / 1155 |
ovary | 100% | 3972.69 | 180 / 180 | 99% | 19.78 | 424 / 430 |
kidney | 100% | 2795.10 | 89 / 89 | 98% | 37.93 | 881 / 901 |
stomach | 100% | 3039.63 | 358 / 359 | 98% | 21.37 | 279 / 286 |
breast | 100% | 5040.53 | 459 / 459 | 97% | 29.38 | 1087 / 1118 |
intestine | 100% | 4262.89 | 966 / 966 | 96% | 15.73 | 507 / 527 |
thymus | 100% | 3614.68 | 652 / 653 | 96% | 22.08 | 580 / 605 |
skin | 100% | 5427.29 | 1809 / 1809 | 94% | 28.95 | 446 / 472 |
prostate | 100% | 3504.38 | 244 / 245 | 95% | 20.03 | 475 / 502 |
uterus | 100% | 5592.44 | 170 / 170 | 94% | 21.88 | 432 / 459 |
brain | 94% | 2845.83 | 2478 / 2642 | 99% | 29.43 | 701 / 705 |
bladder | 100% | 4198.48 | 21 / 21 | 93% | 14.68 | 468 / 504 |
adrenal gland | 100% | 3148.60 | 258 / 258 | 91% | 18.15 | 210 / 230 |
pancreas | 89% | 1468.50 | 293 / 328 | 97% | 22.76 | 172 / 178 |
liver | 100% | 2073.92 | 225 / 226 | 76% | 10.28 | 310 / 406 |
adipose | 100% | 6286.29 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 8802.19 | 1335 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 6902.72 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 4656.17 | 241 / 241 | 0% | 0 | 0 / 0 |
heart | 98% | 6323.45 | 847 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 96% | 19.73 | 43 / 45 |
lymph node | 0% | 0 | 0 / 0 | 90% | 18.76 | 26 / 29 |
peripheral blood | 79% | 3696.01 | 732 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 66% | 8.56 | 53 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0046326 | Biological process | positive regulation of glucose import |
GO_0000165 | Biological process | MAPK cascade |
GO_0007507 | Biological process | heart development |
GO_0010613 | Biological process | positive regulation of cardiac muscle hypertrophy |
GO_0048813 | Biological process | dendrite morphogenesis |
GO_0010628 | Biological process | positive regulation of gene expression |
GO_0048311 | Biological process | mitochondrion distribution |
GO_0055005 | Biological process | ventricular cardiac myofibril assembly |
GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
GO_0070375 | Biological process | ERK5 cascade |
GO_0071277 | Biological process | cellular response to calcium ion |
GO_0006351 | Biological process | DNA-templated transcription |
GO_0030154 | Biological process | cell differentiation |
GO_0061337 | Biological process | cardiac conduction |
GO_0007517 | Biological process | muscle organ development |
GO_0006915 | Biological process | apoptotic process |
GO_0000002 | Biological process | mitochondrial genome maintenance |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0000785 | Cellular component | chromatin |
GO_0005667 | Cellular component | transcription regulator complex |
GO_0005634 | Cellular component | nucleus |
GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
GO_0140297 | Molecular function | DNA-binding transcription factor binding |
GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
GO_0000977 | Molecular function | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
GO_0043565 | Molecular function | sequence-specific DNA binding |
GO_0003682 | Molecular function | chromatin binding |
GO_0019901 | Molecular function | protein kinase binding |
GO_0046332 | Molecular function | SMAD binding |
GO_0061629 | Molecular function | RNA polymerase II-specific DNA-binding transcription factor binding |
GO_0003700 | Molecular function | DNA-binding transcription factor activity |
GO_0035035 | Molecular function | histone acetyltransferase binding |
GO_0046982 | Molecular function | protein heterodimerization activity |
GO_0005515 | Molecular function | protein binding |
GO_0042826 | Molecular function | histone deacetylase binding |
Gene name | MEF2A |
Protein name | Myocyte enhancer factor 2A isoform 5 MADS box transcription enhancer factor 2, polypeptide A (Myocyte enhancer factor 2A), isoform CRA_a (Myocyte enhancer factor 2A isoform 2) MADS box transcription enhancer factor 2, polypeptide A (Myocyte enhancer factor 2A), isoform CRA_b (Myocyte enhancer factor 2A isoform 1) MADS box transcription enhancer factor 2, polypeptide A (Myocyte enhancer factor 2A), isoform CRA_d (Myocyte enhancer factor 2A isoform 3) Myocyte enhancer factor 2A isoform 4 Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1) Alternative protein MEF2A Myocyte enhancer factor 2A |
Synonyms | hCG_1993173 MEF2 |
Description | FUNCTION: Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter. . |
Accessions | Q02078 A0A8I5KPE6 ENST00000560493.5 ENST00000354410.9 [Q02078-5] ENST00000558049.5 A0A0S2Z4N0 ENST00000691492.1 [Q02078-6] A0A0S2Z453 A0A0S2Z454 H0YM62 H0YKY6 ENST00000449277.6 [Q02078-8] ENST00000557785.5 [Q02078-6] A0A0S2Z417 ENST00000558812.5 [Q02078-7] ENST00000559903.1 ENST00000686611.1 [Q02078-1] ENST00000705985.1 ENST00000690055.1 A0A0S2Z4C8 ENST00000557942.6 [Q02078-2] A0A8I5KVQ4 L0R504 ENST00000685785.1 ENST00000338042.11 H0YNI2 |