Biological process

BMK cascade, BMK signaling pathway, BMK signalling pathway, BMK1 cascade, ERK5 signaling pathway, MAPK7 cascade, big MAP kinase signaling cascade, extracellular signal-regulated kinase 5 cascade

A MAPK cascade containing at least the ERK5 MAP kinase (MAPK7; also called BMK1). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of ERK5. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The ERK5 cascade is activated by stress, mitogens, and by G protein-coupled receptors, and results in cellular responses such as cell growth, cell differentiation and development.