MAP2K5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043154Biological processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0090051Biological processnegative regulation of cell migration involved in sprouting angiogenesis
GO_0051247Biological processpositive regulation of protein metabolic process
GO_0000165Biological processMAPK cascade
GO_0030307Biological processpositive regulation of cell growth
GO_0007507Biological processheart development
GO_0048009Biological processinsulin-like growth factor receptor signaling pathway
GO_0007165Biological processsignal transduction
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0071363Biological processcellular response to growth factor stimulus
GO_0070375Biological processERK5 cascade
GO_0032088Biological processnegative regulation of NF-kappaB transcription factor activity
GO_0034392Biological processnegative regulation of smooth muscle cell apoptotic process
GO_0060761Biological processnegative regulation of response to cytokine stimulus
GO_0034115Biological processnegative regulation of heterotypic cell-cell adhesion
GO_0043406Biological processpositive regulation of MAP kinase activity
GO_0050679Biological processpositive regulation of epithelial cell proliferation
GO_0032717Biological processnegative regulation of interleukin-8 production
GO_2001240Biological processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO_0071499Biological processcellular response to laminar fluid shear stress
GO_2000342Biological processnegative regulation of chemokine (C-X-C motif) ligand 2 production
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005819Cellular componentspindle
GO_0106310Molecular functionprotein serine kinase activity
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0004708Molecular functionMAP kinase kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0004672Molecular functionprotein kinase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMAP2K5
Protein nameDual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5)
Mitogen-activated protein kinase kinase 5
mitogen-activated protein kinase kinase (EC 2.7.12.2)
SynonymsMKK5
PRKMK5
MEK5
DescriptionFUNCTION: Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). .

AccessionsENST00000559262.5
ENST00000395476.6 [Q13163-2]
ENST00000557869.2
A0A087WWX7
ENST00000340972.8
H7BZL1
ENST00000178640.10 [Q13163-1]
Q13163
ENST00000354498.9 [Q13163-4]
A6NK28
ENST00000439036.5
A0A087X0Z8