Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 18 studies | 33% ± 13% | |
| astrocyte | 15 studies | 39% ± 16% | |
| glutamatergic neuron | 13 studies | 46% ± 27% | |
| oligodendrocyte | 13 studies | 33% ± 12% | |
| oligodendrocyte precursor cell | 12 studies | 38% ± 14% | |
| GABAergic neuron | 11 studies | 43% ± 24% | |
| microglial cell | 11 studies | 32% ± 10% | |
| fibroblast | 10 studies | 28% ± 11% | |
| macrophage | 9 studies | 34% ± 13% | |
| adipocyte | 9 studies | 33% ± 9% | |
| interneuron | 6 studies | 54% ± 20% | |
| endothelial cell of lymphatic vessel | 6 studies | 31% ± 9% | |
| pericyte | 6 studies | 24% ± 9% | |
| smooth muscle cell | 6 studies | 22% ± 5% | |
| neuron | 5 studies | 44% ± 14% | |
| type I pneumocyte | 5 studies | 26% ± 6% | |
| type II pneumocyte | 5 studies | 26% ± 5% | |
| granule cell | 4 studies | 33% ± 15% | |
| cardiac muscle cell | 4 studies | 31% ± 3% | |
| dendritic cell | 4 studies | 21% ± 3% | |
| Mueller cell | 4 studies | 30% ± 9% | |
| amacrine cell | 4 studies | 30% ± 14% | |
| retinal cone cell | 4 studies | 24% ± 10% | |
| retinal rod cell | 4 studies | 23% ± 5% | |
| myeloid cell | 4 studies | 25% ± 3% | |
| epithelial cell | 4 studies | 31% ± 18% | |
| club cell | 4 studies | 27% ± 8% | |
| monocyte | 4 studies | 28% ± 6% | |
| mast cell | 4 studies | 22% ± 5% | |
| GABAergic interneuron | 3 studies | 41% ± 3% | |
| GABAergic amacrine cell | 3 studies | 27% ± 11% | |
| glycinergic amacrine cell | 3 studies | 29% ± 6% | |
| retina horizontal cell | 3 studies | 24% ± 9% | |
| endothelial cell of vascular tree | 3 studies | 32% ± 17% | |
| hepatocyte | 3 studies | 46% ± 15% | |
| ependymal cell | 3 studies | 38% ± 21% | |
| T cell | 3 studies | 24% ± 1% | |
| alveolar macrophage | 3 studies | 31% ± 7% | |
| capillary endothelial cell | 3 studies | 29% ± 5% | |
| ciliated cell | 3 studies | 25% ± 6% | |
| natural killer cell | 3 studies | 22% ± 3% | |
| lymphocyte | 3 studies | 29% ± 10% | |
| basal cell | 3 studies | 37% ± 18% | |
| mucus secreting cell | 3 studies | 23% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 1369.67 | 2636 / 2642 | 100% | 19.10 | 705 / 705 |
| ovary | 100% | 1722.39 | 180 / 180 | 100% | 11.52 | 429 / 430 |
| prostate | 100% | 1192.69 | 245 / 245 | 100% | 15.76 | 500 / 502 |
| thymus | 100% | 1291.41 | 653 / 653 | 100% | 15.51 | 602 / 605 |
| intestine | 100% | 1521.82 | 966 / 966 | 99% | 12.20 | 524 / 527 |
| uterus | 100% | 1475.71 | 170 / 170 | 99% | 12.29 | 456 / 459 |
| stomach | 100% | 1055.77 | 359 / 359 | 99% | 10.77 | 284 / 286 |
| pancreas | 100% | 843.06 | 327 / 328 | 99% | 10.64 | 177 / 178 |
| skin | 100% | 1614.72 | 1808 / 1809 | 99% | 18.23 | 468 / 472 |
| breast | 100% | 1465.32 | 459 / 459 | 99% | 13.46 | 1106 / 1118 |
| esophagus | 100% | 1192.96 | 1445 / 1445 | 99% | 9.25 | 181 / 183 |
| bladder | 100% | 1362.00 | 21 / 21 | 99% | 10.74 | 498 / 504 |
| lung | 100% | 1154.98 | 576 / 578 | 99% | 11.08 | 1141 / 1155 |
| kidney | 100% | 1028.02 | 89 / 89 | 98% | 11.63 | 884 / 901 |
| liver | 100% | 647.92 | 226 / 226 | 96% | 8.50 | 391 / 406 |
| adrenal gland | 100% | 1613.74 | 258 / 258 | 95% | 18.05 | 219 / 230 |
| adipose | 100% | 1471.34 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 26.43 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 12.15 | 29 / 29 |
| muscle | 100% | 1482.90 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 1159.24 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 12.84 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 3.95 | 1 / 1 |
| blood vessel | 100% | 1310.94 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| heart | 99% | 1027.32 | 850 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 91% | 633.72 | 841 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0043154 | Biological process | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| GO_0090051 | Biological process | negative regulation of cell migration involved in sprouting angiogenesis |
| GO_0051247 | Biological process | positive regulation of protein metabolic process |
| GO_0000165 | Biological process | MAPK cascade |
| GO_0030307 | Biological process | positive regulation of cell growth |
| GO_0007507 | Biological process | heart development |
| GO_0048009 | Biological process | insulin-like growth factor receptor signaling pathway |
| GO_0007165 | Biological process | signal transduction |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0071363 | Biological process | cellular response to growth factor stimulus |
| GO_0070375 | Biological process | ERK5 cascade |
| GO_0032088 | Biological process | negative regulation of NF-kappaB transcription factor activity |
| GO_0034392 | Biological process | negative regulation of smooth muscle cell apoptotic process |
| GO_0060761 | Biological process | negative regulation of response to cytokine stimulus |
| GO_0034115 | Biological process | negative regulation of heterotypic cell-cell adhesion |
| GO_0043406 | Biological process | positive regulation of MAP kinase activity |
| GO_0050679 | Biological process | positive regulation of epithelial cell proliferation |
| GO_0032717 | Biological process | negative regulation of interleukin-8 production |
| GO_2001240 | Biological process | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| GO_0071499 | Biological process | cellular response to laminar fluid shear stress |
| GO_2000342 | Biological process | negative regulation of chemokine (C-X-C motif) ligand 2 production |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0005819 | Cellular component | spindle |
| GO_0106310 | Molecular function | protein serine kinase activity |
| GO_0004713 | Molecular function | protein tyrosine kinase activity |
| GO_0004708 | Molecular function | MAP kinase kinase activity |
| GO_0004674 | Molecular function | protein serine/threonine kinase activity |
| GO_0004672 | Molecular function | protein kinase activity |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0005524 | Molecular function | ATP binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | MAP2K5 |
| Protein name | Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5) Mitogen-activated protein kinase kinase 5 mitogen-activated protein kinase kinase (EC 2.7.12.2) |
| Synonyms | MKK5 PRKMK5 MEK5 |
| Description | FUNCTION: Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). . |
| Accessions | ENST00000559262.5 ENST00000395476.6 [Q13163-2] ENST00000557869.2 A0A087WWX7 ENST00000340972.8 H7BZL1 ENST00000178640.10 [Q13163-1] Q13163 ENST00000354498.9 [Q13163-4] A6NK28 ENST00000439036.5 A0A087X0Z8 |