PABPN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071222Biological processcellular response to lipopolysaccharide
GO_1904247Biological processpositive regulation of polynucleotide adenylyltransferase activity
GO_0006397Biological processmRNA processing
GO_0006936Biological processmuscle contraction
GO_0016973Biological processpoly(A)+ mRNA export from nucleus
GO_0000165Biological processMAPK cascade
GO_0006396Biological processRNA processing
GO_0042405Cellular componentnuclear inclusion body
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_1990904Cellular componentribonucleoprotein complex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0070063Molecular functionRNA polymerase binding
GO_0008143Molecular functionpoly(A) binding
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene namePABPN1
Protein namePolyadenylate-binding protein 2 (PABP-2) (Poly(A)-binding protein 2) (Nuclear poly(A)-binding protein 1) (Poly(A)-binding protein II) (PABII) (Polyadenylate-binding nuclear protein 1)
Poly(A) binding protein nuclear 1
Poly(A) binding protein nuclear 1 (cDNA FLJ57714, highly similar to Poly(A)-binding protein 2)
SynonymsPABP2
PAB2
DescriptionFUNCTION: Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (By similarity). Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length (By similarity). Increases the affinity of poly(A) polymerase for RNA (By similarity). Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes . Binds to poly(A) and to poly(G) with high affinity (By similarity). May protect the poly(A) tail from degradation (By similarity). Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters . .

AccessionsH0YJH9
ENST00000556821.5
Q86U42
ENST00000557702.5
G3V4T2
B4DEH8
ENST00000216727.9 [Q86U42-1]
ENST00000397276.6 [Q86U42-2]
ENST00000555295.1