PEA15 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_1902042Biological processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO_1902043Biological processpositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO_0000165Biological processMAPK cascade
GO_0046325Biological processnegative regulation of glucose import
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005875Cellular componentmicrotubule associated complex
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePEA15
Protein nameAstrocytic phosphoprotein PEA-15 (15 kDa phosphoprotein enriched in astrocytes) (Phosphoprotein enriched in diabetes) (PED)
Proliferation and apoptosis adaptor protein 15
Astrocytic phosphoprotein PEA-15 (15 kDa phosphoprotein enriched in astrocytes)
SynonymshCG_39732
DescriptionFUNCTION: Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface. .

AccessionsENST00000368077.5
ENST00000360472.9 [Q15121-1]
ENST00000368076.1 [Q15121-2]
B1AKZ5
B1AKZ4
Q15121
Q6FHL9