DUSP6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000165Biological processMAPK cascade
GO_0070373Biological processnegative regulation of ERK1 and ERK2 cascade
GO_0014070Biological processresponse to organic cyclic compound
GO_0051409Biological processresponse to nitrosative stress
GO_0035335Biological processpeptidyl-tyrosine dephosphorylation
GO_0060420Biological processregulation of heart growth
GO_0001933Biological processnegative regulation of protein phosphorylation
GO_0070371Biological processERK1 and ERK2 cascade
GO_0030154Biological processcell differentiation
GO_0043409Biological processnegative regulation of MAPK cascade
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0043065Biological processpositive regulation of apoptotic process
GO_0070848Biological processresponse to growth factor
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0017018Molecular functionmyosin phosphatase activity
GO_0017017Molecular functionMAP kinase tyrosine/serine/threonine phosphatase activity
GO_0008138Molecular functionprotein tyrosine/serine/threonine phosphatase activity
GO_0008330Molecular functionprotein tyrosine/threonine phosphatase activity
GO_0033550Molecular functionMAP kinase tyrosine phosphatase activity
GO_0005515Molecular functionprotein binding
GO_0004725Molecular functionprotein tyrosine phosphatase activity

IV. Literature review

[source]
Gene nameDUSP6
Protein nameDual specificity phosphatase 6
Dual specificity protein phosphatase 6 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PYST1) (Mitogen-activated protein kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3)
Dual specificity protein phosphatase (EC 3.1.3.16) (EC 3.1.3.48)
SynonymsPYST1
MKP3
DescriptionFUNCTION: Inactivates MAP kinases. Has a specificity for the ERK family . Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors . .

AccessionsENST00000548755.1
ENST00000547291.1
F8VZA4
Q16828
B5BU29
ENST00000279488.8 [Q16828-1]
ENST00000308385.6 [Q16828-2]
F8VW29
Q689E8