Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 33 studies | 33% ± 12% | |
classical monocyte | 25 studies | 44% ± 14% | |
non-classical monocyte | 25 studies | 44% ± 14% | |
macrophage | 24 studies | 31% ± 14% | |
mast cell | 21 studies | 37% ± 15% | |
monocyte | 18 studies | 34% ± 10% | |
capillary endothelial cell | 14 studies | 35% ± 19% | |
endothelial cell of lymphatic vessel | 13 studies | 35% ± 13% | |
vein endothelial cell | 11 studies | 31% ± 12% | |
endothelial cell of vascular tree | 10 studies | 33% ± 7% | |
type II pneumocyte | 9 studies | 29% ± 12% | |
basal cell | 9 studies | 26% ± 5% | |
endothelial cell of artery | 8 studies | 30% ± 11% | |
myeloid cell | 8 studies | 35% ± 15% | |
epithelial cell | 6 studies | 29% ± 17% | |
adipocyte | 6 studies | 21% ± 4% | |
oligodendrocyte precursor cell | 6 studies | 26% ± 11% | |
mononuclear phagocyte | 5 studies | 33% ± 18% | |
conventional dendritic cell | 5 studies | 28% ± 11% | |
abnormal cell | 5 studies | 22% ± 7% | |
pericyte | 5 studies | 26% ± 12% | |
fibroblast | 5 studies | 25% ± 9% | |
intermediate monocyte | 5 studies | 54% ± 13% | |
hematopoietic precursor cell | 4 studies | 21% ± 3% | |
retinal pigment epithelial cell | 4 studies | 42% ± 17% | |
dendritic cell | 3 studies | 27% ± 12% | |
tissue-resident macrophage | 3 studies | 37% ± 18% | |
neutrophil | 3 studies | 27% ± 3% | |
granulocyte | 3 studies | 45% ± 16% | |
leukocyte | 3 studies | 20% ± 3% | |
glial cell | 3 studies | 36% ± 22% | |
hepatocyte | 3 studies | 43% ± 23% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
thymus | 100% | 2667.46 | 652 / 653 | 95% | 344.18 | 576 / 605 |
intestine | 99% | 2365.19 | 961 / 966 | 93% | 69.01 | 490 / 527 |
bladder | 100% | 2144.57 | 21 / 21 | 90% | 82.33 | 455 / 504 |
skin | 91% | 1581.94 | 1649 / 1809 | 98% | 191.04 | 462 / 472 |
lung | 99% | 5503.25 | 575 / 578 | 89% | 105.17 | 1028 / 1155 |
kidney | 100% | 3626.42 | 89 / 89 | 82% | 66.18 | 739 / 901 |
breast | 100% | 4709.86 | 459 / 459 | 80% | 50.38 | 892 / 1118 |
stomach | 92% | 1474.42 | 329 / 359 | 87% | 50.27 | 248 / 286 |
esophagus | 94% | 1953.25 | 1357 / 1445 | 84% | 53.47 | 154 / 183 |
liver | 100% | 3265.37 | 226 / 226 | 77% | 42.62 | 313 / 406 |
adrenal gland | 98% | 1463.58 | 254 / 258 | 72% | 44.58 | 166 / 230 |
uterus | 94% | 1602.73 | 160 / 170 | 71% | 56.80 | 324 / 459 |
pancreas | 62% | 548.98 | 203 / 328 | 98% | 80.14 | 175 / 178 |
brain | 83% | 1289.83 | 2194 / 2642 | 64% | 41.34 | 448 / 705 |
prostate | 98% | 1873.53 | 239 / 245 | 40% | 13.75 | 200 / 502 |
ovary | 53% | 605.55 | 95 / 180 | 80% | 52.96 | 344 / 430 |
adipose | 100% | 5885.48 | 1204 / 1204 | 0% | 0 | 0 / 0 |
spleen | 100% | 5783.29 | 241 / 241 | 0% | 0 | 0 / 0 |
heart | 97% | 1883.91 | 836 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 93% | 52.64 | 74 / 80 |
blood vessel | 80% | 1842.65 | 1074 / 1335 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 69% | 36.18 | 31 / 45 |
peripheral blood | 69% | 1568.32 | 639 / 929 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 55% | 19.31 | 16 / 29 |
muscle | 33% | 285.52 | 267 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0000165 | Biological process | MAPK cascade |
GO_0070373 | Biological process | negative regulation of ERK1 and ERK2 cascade |
GO_0014070 | Biological process | response to organic cyclic compound |
GO_0051409 | Biological process | response to nitrosative stress |
GO_0035335 | Biological process | peptidyl-tyrosine dephosphorylation |
GO_0060420 | Biological process | regulation of heart growth |
GO_0001933 | Biological process | negative regulation of protein phosphorylation |
GO_0070371 | Biological process | ERK1 and ERK2 cascade |
GO_0030154 | Biological process | cell differentiation |
GO_0043409 | Biological process | negative regulation of MAPK cascade |
GO_0009410 | Biological process | response to xenobiotic stimulus |
GO_0043065 | Biological process | positive regulation of apoptotic process |
GO_0070848 | Biological process | response to growth factor |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0017018 | Molecular function | myosin phosphatase activity |
GO_0017017 | Molecular function | MAP kinase tyrosine/serine/threonine phosphatase activity |
GO_0008138 | Molecular function | protein tyrosine/serine/threonine phosphatase activity |
GO_0008330 | Molecular function | protein tyrosine/threonine phosphatase activity |
GO_0033550 | Molecular function | MAP kinase tyrosine phosphatase activity |
GO_0005515 | Molecular function | protein binding |
GO_0004725 | Molecular function | protein tyrosine phosphatase activity |
Gene name | DUSP6 |
Protein name | Dual specificity phosphatase 6 Dual specificity protein phosphatase 6 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PYST1) (Mitogen-activated protein kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3) Dual specificity protein phosphatase (EC 3.1.3.16) (EC 3.1.3.48) |
Synonyms | PYST1 MKP3 |
Description | FUNCTION: Inactivates MAP kinases. Has a specificity for the ERK family . Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors . . |
Accessions | ENST00000548755.1 ENST00000547291.1 F8VZA4 Q16828 B5BU29 ENST00000279488.8 [Q16828-1] ENST00000308385.6 [Q16828-2] F8VW29 Q689E8 |