FGFR3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FGFR3 at tissue level.

III. Associated gene sets

GO_0048640Biological processnegative regulation of developmental growth
GO_0042531Biological processpositive regulation of tyrosine phosphorylation of STAT protein
GO_0060349Biological processbone morphogenesis
GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0000165Biological processMAPK cascade
GO_0002062Biological processchondrocyte differentiation
GO_0035988Biological processchondrocyte proliferation
GO_0007275Biological processmulticellular organism development
GO_0070977Biological processbone maturation
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0001958Biological processendochondral ossification
GO_0007267Biological processcell-cell signaling
GO_1902178Biological processfibroblast growth factor receptor apoptotic signaling pathway
GO_0033674Biological processpositive regulation of kinase activity
GO_0030282Biological processbone mineralization
GO_0001501Biological processskeletal system development
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0010518Biological processpositive regulation of phospholipase activity
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0003416Biological processendochondral bone growth
GO_0007259Biological processcell surface receptor signaling pathway via JAK-STAT
GO_0008543Biological processfibroblast growth factor receptor signaling pathway
GO_0043235Cellular componentreceptor complex
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0005794Cellular componentGolgi apparatus
GO_0005925Cellular componentfocal adhesion
GO_0009986Cellular componentcell surface
GO_0005783Cellular componentendoplasmic reticulum
GO_0030133Cellular componenttransport vesicle
GO_0005007Molecular functionfibroblast growth factor receptor activity
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0042802Molecular functionidentical protein binding
GO_0005524Molecular functionATP binding
GO_0017134Molecular functionfibroblast growth factor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFGFR3
Protein nameFibroblast growth factor receptor 3 isoform B
Fibroblast growth factor receptor 3 IIIc isoform
Fibroblast growth factor receptor
Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333)
Fibroblast growth factor receptor 3
Fibroblast growth factor receptor 3 isoform C
Mutant fibroblast growth factor receptor 3
Fibroblast growth factor receptor 3 (EC 2.7.10.1)
Fibroblast growth factor receptor (EC 2.7.10.1)
SynonymsJTK4
DescriptionFUNCTION: Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B. Secreted isoform 3 retains its capacity to bind FGF1 and FGF2 and hence may interfere with FGF signaling. .

AccessionsQ96T36
A0A5P8NAS4
X5D2G8
I6LM06
A0A3S5WLI4
Q9NRB6
A0N9W0
Q96T34
ENST00000440486.8 [P22607-1]
ENST00000481110.7
F8W9L4
Q96T35
ENST00000352904.6 [P22607-3]
Q8NI15
ENST00000260795.8
A0A3S5XAL5
Q8NI16
Q0IJ44
A8E633
P22607
ENST00000507588.1
X5D9H5
ENST00000412135.7
A0A7I2RW32
ENST00000340107.9 [P22607-2]
X5D2W2