Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 6 studies | 22% ± 7% | |
| epithelial cell | 4 studies | 25% ± 4% | |
| astrocyte | 4 studies | 26% ± 6% | |
| glutamatergic neuron | 4 studies | 39% ± 16% | |
| microglial cell | 3 studies | 19% ± 2% | |
| GABAergic neuron | 3 studies | 43% ± 8% | |
| transit amplifying cell | 3 studies | 23% ± 10% | |
| neuron | 3 studies | 22% ± 6% | |
| interneuron | 3 studies | 33% ± 17% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 33% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 100% | 1663.73 | 459 / 459 | 100% | 22.70 | 1118 / 1118 |
| prostate | 100% | 2380.53 | 245 / 245 | 100% | 23.78 | 502 / 502 |
| thymus | 100% | 2701.36 | 653 / 653 | 100% | 27.53 | 605 / 605 |
| uterus | 100% | 2352.69 | 170 / 170 | 100% | 21.85 | 459 / 459 |
| brain | 100% | 4360.36 | 2641 / 2642 | 100% | 33.06 | 705 / 705 |
| skin | 100% | 2680.30 | 1808 / 1809 | 100% | 30.06 | 472 / 472 |
| stomach | 100% | 1760.53 | 358 / 359 | 100% | 18.92 | 286 / 286 |
| intestine | 100% | 2157.15 | 966 / 966 | 100% | 18.60 | 525 / 527 |
| kidney | 100% | 3115.47 | 89 / 89 | 100% | 29.79 | 897 / 901 |
| esophagus | 100% | 2322.52 | 1445 / 1445 | 99% | 21.91 | 182 / 183 |
| bladder | 100% | 2060.76 | 21 / 21 | 99% | 20.91 | 501 / 504 |
| lung | 100% | 2035.05 | 576 / 578 | 100% | 21.86 | 1151 / 1155 |
| ovary | 100% | 1873.40 | 180 / 180 | 99% | 19.23 | 426 / 430 |
| pancreas | 98% | 1569.23 | 323 / 328 | 100% | 17.41 | 178 / 178 |
| adrenal gland | 100% | 3026.21 | 258 / 258 | 97% | 14.68 | 223 / 230 |
| liver | 96% | 1128.04 | 218 / 226 | 97% | 12.18 | 393 / 406 |
| adipose | 100% | 1629.62 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 26.46 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 21.94 | 29 / 29 |
| muscle | 100% | 2771.22 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 2252.51 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 17.04 | 1 / 1 |
| blood vessel | 100% | 1560.82 | 1330 / 1335 | 0% | 0 | 0 / 0 |
| heart | 99% | 2553.08 | 853 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 23.71 | 44 / 45 |
| peripheral blood | 74% | 987.76 | 685 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_2000177 | Biological process | regulation of neural precursor cell proliferation |
| GO_0042475 | Biological process | odontogenesis of dentin-containing tooth |
| GO_0014010 | Biological process | Schwann cell proliferation |
| GO_0033687 | Biological process | osteoblast proliferation |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0021766 | Biological process | hippocampus development |
| GO_0046426 | Biological process | negative regulation of receptor signaling pathway via JAK-STAT |
| GO_0035330 | Biological process | regulation of hippo signaling |
| GO_0000165 | Biological process | MAPK cascade |
| GO_0033689 | Biological process | negative regulation of osteoblast proliferation |
| GO_0051496 | Biological process | positive regulation of stress fiber assembly |
| GO_2000643 | Biological process | positive regulation of early endosome to late endosome transport |
| GO_0001953 | Biological process | negative regulation of cell-matrix adhesion |
| GO_0010626 | Biological process | negative regulation of Schwann cell proliferation |
| GO_1902966 | Biological process | positive regulation of protein localization to early endosome |
| GO_0045216 | Biological process | cell-cell junction organization |
| GO_0022408 | Biological process | negative regulation of cell-cell adhesion |
| GO_0030036 | Biological process | actin cytoskeleton organization |
| GO_0045597 | Biological process | positive regulation of cell differentiation |
| GO_0072091 | Biological process | regulation of stem cell proliferation |
| GO_0042981 | Biological process | regulation of apoptotic process |
| GO_1902115 | Biological process | regulation of organelle assembly |
| GO_0001707 | Biological process | mesoderm formation |
| GO_0014013 | Biological process | regulation of gliogenesis |
| GO_0043409 | Biological process | negative regulation of MAPK cascade |
| GO_0030336 | Biological process | negative regulation of cell migration |
| GO_0008360 | Biological process | regulation of cell shape |
| GO_1900180 | Biological process | regulation of protein localization to nucleus |
| GO_0070306 | Biological process | lens fiber cell differentiation |
| GO_0051726 | Biological process | regulation of cell cycle |
| GO_0042532 | Biological process | negative regulation of tyrosine phosphorylation of STAT protein |
| GO_0007398 | Biological process | ectoderm development |
| GO_0031647 | Biological process | regulation of protein stability |
| GO_0032587 | Cellular component | ruffle membrane |
| GO_0005730 | Cellular component | nucleolus |
| GO_0005856 | Cellular component | cytoskeleton |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0016020 | Cellular component | membrane |
| GO_0005769 | Cellular component | early endosome |
| GO_0030864 | Cellular component | cortical actin cytoskeleton |
| GO_0043005 | Cellular component | neuron projection |
| GO_0030175 | Cellular component | filopodium |
| GO_0031527 | Cellular component | filopodium membrane |
| GO_0005829 | Cellular component | cytosol |
| GO_0005912 | Cellular component | adherens junction |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0044297 | Cellular component | cell body |
| GO_0032154 | Cellular component | cleavage furrow |
| GO_0030027 | Cellular component | lamellipodium |
| GO_0045177 | Cellular component | apical part of cell |
| GO_0005634 | Cellular component | nucleus |
| GO_0005178 | Molecular function | integrin binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0003779 | Molecular function | actin binding |
| Gene name | NF2 |
| Protein name | NF2 protein NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor Merlin variant 14 Neurofibromatosis type 2 Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin) Neurofibromin 2 |
| Synonyms | SCH |
| Description | FUNCTION: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex. . |
| Accessions | A0A5F9ZHD8 ENST00000673312.2 ENST00000403999.7 [P35240-3] ENST00000338641.10 [P35240-1] A0A286SD34 ENST00000361676.8 [P35240-6] ENST00000397789.3 [P35240-3] ENST00000672805.1 A0A286SD19 P35240 ENST00000672461.1 [P35240-3] ENST00000334961.11 [P35240-4] A5A158 ENST00000413209.6 [P35240-9] Q16231 ENST00000403435.5 [P35240-8] Q16276 Q7KZ66 ENST00000353887.8 [P35240-4] ENST00000361452.8 [P35240-5] Q16232 A0A5F9ZHA0 A0A5K1VW66 Q16230 ENST00000672896.1 [P35240-3] Q9NRW8 ENST00000361166.10 A0A286SD20 Q16233 ENST00000432151.5 [P35240-10] |
