KRAS | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	22 studies	24% ± 7%	Explore
CD4-positive, alpha-beta T cell	19 studies	22% ± 6%	Explore
B cell	18 studies	21% ± 5%	Explore
natural killer cell	18 studies	22% ± 6%	Explore
CD8-positive, alpha-beta T cell	18 studies	25% ± 7%	Explore
non-classical monocyte	16 studies	28% ± 12%	Explore
macrophage	15 studies	19% ± 4%	Explore
epithelial cell	13 studies	31% ± 15%	Explore
classical monocyte	13 studies	22% ± 9%	Explore
T cell	11 studies	21% ± 5%	Explore
monocyte	11 studies	20% ± 3%	Explore
endothelial cell of lymphatic vessel	11 studies	23% ± 4%	Explore
memory B cell	10 studies	22% ± 6%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	24% ± 7%	Explore
mature NK T cell	9 studies	20% ± 3%	Explore
capillary endothelial cell	9 studies	17% ± 2%	Explore
gamma-delta T cell	9 studies	25% ± 9%	Explore
CD16-positive, CD56-dim natural killer cell, human	8 studies	23% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	27% ± 8%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	26% ± 6%	Explore
endothelial cell of artery	8 studies	19% ± 2%	Explore
regulatory T cell	8 studies	19% ± 4%	Explore
basal cell	7 studies	30% ± 15%	Explore
respiratory goblet cell	7 studies	25% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	22% ± 4%	Explore
vein endothelial cell	7 studies	21% ± 6%	Explore
abnormal cell	7 studies	20% ± 4%	Explore
endothelial cell of vascular tree	7 studies	21% ± 2%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	24% ± 5%	Explore
secretory cell	6 studies	30% ± 14%	Explore
naive B cell	6 studies	23% ± 3%	Explore
conventional dendritic cell	6 studies	26% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	25% ± 5%	Explore
fibroblast	6 studies	22% ± 4%	Explore
connective tissue cell	6 studies	18% ± 2%	Explore
retinal rod cell	6 studies	22% ± 3%	Explore
T follicular helper cell	6 studies	20% ± 2%	Explore
type I pneumocyte	5 studies	19% ± 2%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	31% ± 13%	Explore
neuron	5 studies	24% ± 7%	Explore
precursor B cell	5 studies	25% ± 7%	Explore
ciliated cell	5 studies	33% ± 14%	Explore
retinal cone cell	5 studies	33% ± 11%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	25% ± 6%	Explore
innate lymphoid cell	5 studies	19% ± 2%	Explore
goblet cell	5 studies	32% ± 16%	Explore
plasmacytoid dendritic cell	5 studies	21% ± 6%	Explore
plasmablast	4 studies	45% ± 17%	Explore
leukocyte	4 studies	22% ± 4%	Explore
exhausted T cell	4 studies	32% ± 6%	Explore
lymphocyte	4 studies	24% ± 5%	Explore
mucosal invariant T cell	4 studies	19% ± 2%	Explore
retina horizontal cell	4 studies	23% ± 8%	Explore
dendritic cell	4 studies	35% ± 17%	Explore
GABAergic neuron	4 studies	41% ± 12%	Explore
glutamatergic neuron	4 studies	50% ± 15%	Explore
pericyte	4 studies	18% ± 2%	Explore
interneuron	4 studies	35% ± 19%	Explore
hematopoietic precursor cell	3 studies	29% ± 15%	Explore
club cell	3 studies	28% ± 6%	Explore
squamous epithelial cell	3 studies	41% ± 22%	Explore
pancreatic A cell	3 studies	27% ± 7%	Explore
retinal bipolar neuron	3 studies	23% ± 5%	Explore
myeloid cell	3 studies	30% ± 7%	Explore
plasma cell	3 studies	27% ± 12%	Explore
amacrine cell	3 studies	31% ± 11%	Explore
mononuclear phagocyte	3 studies	21% ± 4%	Explore
rod bipolar cell	3 studies	19% ± 4%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	25% ± 4%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	17% ± 0%	Explore
enterocyte	3 studies	19% ± 2%	Explore
enteroendocrine cell	3 studies	24% ± 6%	Explore
group 3 innate lymphoid cell	3 studies	30% ± 11%	Explore
mast cell	3 studies	19% ± 3%	Explore
microglial cell	3 studies	21% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	10 studies	26% ± 9%	Explore
lung	9 studies	26% ± 13%	Explore
eye	6 studies	21% ± 5%	Explore
brain	6 studies	31% ± 15%	Explore
lymph node	4 studies	18% ± 2%	Explore
intestine	4 studies	21% ± 6%	Explore
pancreas	3 studies	27% ± 11%	Explore
bone marrow	3 studies	19% ± 2%	Explore
liver	3 studies	27% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3523.31	1445 / 1445	100%	65.71	183 / 183
lung	100%	2955.15	578 / 578	100%	38.48	1155 / 1155
breast	100%	2133.42	459 / 459	100%	32.79	1116 / 1118
ovary	100%	1736.91	180 / 180	100%	35.32	429 / 430
brain	100%	2296.01	2631 / 2642	100%	23.91	705 / 705
uterus	100%	2107.26	170 / 170	99%	28.79	456 / 459
intestine	100%	3112.03	966 / 966	99%	32.05	520 / 527
bladder	100%	2644.14	21 / 21	99%	26.12	497 / 504
stomach	100%	2646.35	359 / 359	99%	35.21	282 / 286
prostate	100%	1907.64	245 / 245	98%	18.71	493 / 502
thymus	100%	2109.83	652 / 653	98%	15.60	595 / 605
kidney	100%	1859.04	89 / 89	98%	20.38	884 / 901
pancreas	99%	1338.87	325 / 328	98%	26.68	175 / 178
adrenal gland	100%	1765.10	258 / 258	93%	13.20	213 / 230
skin	100%	2612.00	1809 / 1809	91%	16.40	428 / 472
liver	100%	1521.28	226 / 226	80%	9.82	323 / 406
adipose	100%	2311.26	1204 / 1204	0%	0	0 / 0
blood vessel	100%	2256.38	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	21.07	29 / 29
spleen	100%	2169.08	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	26.43	45 / 45
ureter	0%	0	0 / 0	100%	5.24	1 / 1
muscle	99%	1158.83	794 / 803	0%	0	0 / 0
peripheral blood	97%	2188.80	903 / 929	0%	0	0 / 0
heart	97%	1162.19	832 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	53%	5.28	42 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007265	Biological process	Ras protein signal transduction
GO_0032228	Biological process	regulation of synaptic transmission, GABAergic
GO_0048169	Biological process	regulation of long-term neuronal synaptic plasticity
GO_0021897	Biological process	forebrain astrocyte development
GO_0000165	Biological process	MAPK cascade
GO_0060252	Biological process	positive regulation of glial cell proliferation
GO_0010628	Biological process	positive regulation of gene expression
GO_0060441	Biological process	epithelial tube branching involved in lung morphogenesis
GO_0051146	Biological process	striated muscle cell differentiation
GO_0001934	Biological process	positive regulation of protein phosphorylation
GO_0035022	Biological process	positive regulation of Rac protein signal transduction
GO_0008542	Biological process	visual learning
GO_0048873	Biological process	homeostasis of number of cells within a tissue
GO_0051402	Biological process	neuron apoptotic process
GO_0030857	Biological process	negative regulation of epithelial cell differentiation
GO_0030036	Biological process	actin cytoskeleton organization
GO_0060509	Biological process	type I pneumocyte differentiation
GO_0016601	Biological process	Rac protein signal transduction
GO_0010467	Biological process	gene expression
GO_0035914	Biological process	skeletal muscle cell differentiation
GO_0043524	Biological process	negative regulation of neuron apoptotic process
GO_0014009	Biological process	glial cell proliferation
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0009898	Cellular component	cytoplasmic side of plasma membrane
GO_0005925	Cellular component	focal adhesion
GO_0000139	Cellular component	Golgi membrane
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005741	Cellular component	mitochondrial outer membrane
GO_0019003	Molecular function	GDP binding
GO_0043495	Molecular function	protein-membrane adaptor activity
GO_0044877	Molecular function	protein-containing complex binding
GO_0003925	Molecular function	G protein activity
GO_0005525	Molecular function	GTP binding
GO_0005515	Molecular function	protein binding
GO_0003924	Molecular function	GTPase activity

IV. Literature review

[source]

Gene name	KRAS
Protein name	small monomeric GTPase (EC 3.6.5.2) GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed] GTPase KRas (EC 3.6.5.2) (Ki-Ras) KRAS proto-oncogene, GTPase K-Ras GTPase KRas KRAS protein GTPase KRAS (K-ras p21 protein) (K-ras protein) K-ras
Synonyms	KRAS2 'C-K-RAS RASK2 K-RAS2A K-Ras c-Ki-ras2 CFC2
Description	FUNCTION: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity . Plays an important role in the regulation of cell proliferation . Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner . .
Accessions	ENST00000556131.2 ENST00000557334.6 A5HC07 A5HC06 A5HC17 G3V4K2 A5HC20 ENST00000311936.8 [P01116-2] A0A8I5KUB5 A5HC08 A5HC05 A5HC13 ENST00000687356.1 A0A3G1LBH1 A5HC21 A5HC15 Q71SP6 ENST00000256078.10 [P01116-1] A5HC19 A5HC09 ENST00000686969.1 A0A8I5KXN3 A0A221ZRZ5 A0A8I5KQ21 E5FF39 A5HC12 A0A8I5KR86 ENST00000690406.1 A5HC23 A5HC25 A0A8I5KQU3 ENST00000686877.1 A5HC10 ENST00000685328.1 [P01116-2] ENST00000688940.1 [P01116-2] A5HC03 A0A221ZRZ1 A5HC02 A5HC18 ENST00000692768.1 P01116 G3V5T7 A5HC11 A5HC04 A5HC16 ENST00000690804.1 ENST00000693229.1 A0A221ZRZ4 A5HC24 A5HC14 A0A5P8I3H7 L7RSL8 A5HC26 A0A8I5KYH6

KRAS report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review