NLK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1904894Biological processpositive regulation of receptor signaling pathway via STAT
GO_0000165Biological processMAPK cascade
GO_0007223Biological processWnt signaling pathway, calcium modulating pathway
GO_0018107Biological processpeptidyl-threonine phosphorylation
GO_0030178Biological processnegative regulation of Wnt signaling pathway
GO_0035556Biological processintracellular signal transduction
GO_0071470Biological processcellular response to osmotic stress
GO_0050821Biological processprotein stabilization
GO_0006355Biological processregulation of DNA-templated transcription
GO_0006468Biological processprotein phosphorylation
GO_0007179Biological processtransforming growth factor beta receptor signaling pathway
GO_1904262Biological processnegative regulation of TORC1 signaling
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004707Molecular functionMAP kinase activity
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0106310Molecular functionprotein serine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0000287Molecular functionmagnesium ion binding
GO_0004672Molecular functionprotein kinase activity
GO_0042169Molecular functionSH2 domain binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNLK
Protein nameSerine/threonine-protein kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1)
Nemo like kinase
Mitogen-activated protein kinase (EC 2.7.11.24)
SynonymsLAK1
DescriptionFUNCTION: Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination . Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2 . Negative regulator of the canonical Wnt/beta-catenin signaling pathway . Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1 . Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes . Negative regulator of the Notch signaling pathway . Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1 . Negative regulator of the MYB family of transcription factors . Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP . Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself . Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1 . Upon IL1B stimulus, cooperates with ATF5 to activate the transactivation activity of C/EBP subfamily members . Phosphorylates ATF5 but also stabilizes ATF5 protein levels in a kinase-independent manner . Acts as an inhibitor of the mTORC1 complex in response to osmotic stress by mediating phosphorylation of RPTOR, thereby preventing recruitment of the mTORC1 complex to lysosomes . .

AccessionsENST00000407008.8
ENST00000496808.1
J3QSE9
Q9UBE8
H0YD75
ENST00000582037.2