Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 23 studies | 39% ± 13% | |
oligodendrocyte | 15 studies | 53% ± 16% | |
microglial cell | 13 studies | 36% ± 11% | |
glutamatergic neuron | 11 studies | 59% ± 26% | |
oligodendrocyte precursor cell | 11 studies | 34% ± 13% | |
astrocyte | 10 studies | 32% ± 13% | |
GABAergic neuron | 8 studies | 43% ± 21% | |
macrophage | 8 studies | 40% ± 14% | |
pericyte | 7 studies | 21% ± 2% | |
retinal cone cell | 7 studies | 66% ± 24% | |
neuron | 6 studies | 46% ± 18% | |
interneuron | 6 studies | 38% ± 19% | |
retina horizontal cell | 6 studies | 35% ± 17% | |
adipocyte | 6 studies | 20% ± 4% | |
fibroblast | 6 studies | 20% ± 3% | |
retinal bipolar neuron | 5 studies | 51% ± 29% | |
myeloid cell | 5 studies | 31% ± 7% | |
endothelial cell of lymphatic vessel | 5 studies | 25% ± 5% | |
type I pneumocyte | 5 studies | 24% ± 5% | |
retinal pigment epithelial cell | 4 studies | 56% ± 19% | |
cardiac muscle cell | 4 studies | 25% ± 2% | |
dendritic cell | 4 studies | 22% ± 1% | |
amacrine cell | 4 studies | 27% ± 8% | |
retinal rod cell | 4 studies | 66% ± 16% | |
ciliated cell | 4 studies | 20% ± 5% | |
monocyte | 4 studies | 29% ± 11% | |
smooth muscle cell | 4 studies | 20% ± 1% | |
type II pneumocyte | 4 studies | 19% ± 4% | |
GABAergic interneuron | 3 studies | 27% ± 1% | |
endothelial cell of artery | 3 studies | 17% ± 2% | |
vein endothelial cell | 3 studies | 26% ± 5% | |
epithelial cell | 3 studies | 38% ± 22% | |
GABAergic amacrine cell | 3 studies | 43% ± 12% | |
OFF-bipolar cell | 3 studies | 68% ± 26% | |
ON-bipolar cell | 3 studies | 64% ± 26% | |
rod bipolar cell | 3 studies | 69% ± 21% | |
endothelial cell of vascular tree | 3 studies | 31% ± 11% | |
hepatocyte | 3 studies | 38% ± 19% | |
megakaryocyte-erythroid progenitor cell | 3 studies | 31% ± 11% | |
T cell | 3 studies | 18% ± 2% | |
alveolar macrophage | 3 studies | 38% ± 8% | |
capillary endothelial cell | 3 studies | 32% ± 4% | |
club cell | 3 studies | 23% ± 7% | |
lymphocyte | 3 studies | 21% ± 1% | |
mast cell | 3 studies | 26% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 3457.56 | 2641 / 2642 | 100% | 32.30 | 705 / 705 |
esophagus | 100% | 897.05 | 1443 / 1445 | 100% | 17.03 | 183 / 183 |
thymus | 100% | 2166.33 | 653 / 653 | 100% | 23.83 | 604 / 605 |
lung | 100% | 1656.57 | 577 / 578 | 100% | 17.41 | 1155 / 1155 |
breast | 100% | 1405.22 | 459 / 459 | 100% | 27.69 | 1116 / 1118 |
bladder | 100% | 1157.57 | 21 / 21 | 100% | 18.78 | 503 / 504 |
liver | 100% | 851.37 | 226 / 226 | 100% | 12.91 | 405 / 406 |
kidney | 100% | 2316.11 | 89 / 89 | 100% | 22.48 | 898 / 901 |
intestine | 100% | 1238.87 | 966 / 966 | 100% | 15.10 | 525 / 527 |
prostate | 100% | 1331.00 | 245 / 245 | 100% | 19.17 | 500 / 502 |
uterus | 100% | 1156.45 | 170 / 170 | 100% | 14.76 | 457 / 459 |
stomach | 100% | 909.42 | 359 / 359 | 99% | 15.20 | 284 / 286 |
pancreas | 100% | 1392.59 | 327 / 328 | 99% | 14.78 | 177 / 178 |
adrenal gland | 100% | 4783.95 | 258 / 258 | 99% | 24.10 | 228 / 230 |
ovary | 100% | 903.89 | 180 / 180 | 99% | 12.24 | 424 / 430 |
skin | 99% | 854.71 | 1796 / 1809 | 98% | 24.11 | 464 / 472 |
lymph node | 0% | 0 | 0 / 0 | 100% | 24.94 | 29 / 29 |
spleen | 100% | 2179.41 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 11.08 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 15.97 | 1 / 1 |
adipose | 100% | 1405.12 | 1203 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 99% | 886.29 | 1325 / 1335 | 0% | 0 | 0 / 0 |
heart | 99% | 1149.84 | 850 / 861 | 0% | 0 | 0 / 0 |
muscle | 97% | 661.08 | 776 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 91% | 14.73 | 73 / 80 |
peripheral blood | 74% | 859.50 | 692 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_1904894 | Biological process | positive regulation of receptor signaling pathway via STAT |
GO_0000165 | Biological process | MAPK cascade |
GO_0007223 | Biological process | Wnt signaling pathway, calcium modulating pathway |
GO_0018107 | Biological process | peptidyl-threonine phosphorylation |
GO_0030178 | Biological process | negative regulation of Wnt signaling pathway |
GO_0035556 | Biological process | intracellular signal transduction |
GO_0071470 | Biological process | cellular response to osmotic stress |
GO_0050821 | Biological process | protein stabilization |
GO_0006355 | Biological process | regulation of DNA-templated transcription |
GO_0006468 | Biological process | protein phosphorylation |
GO_0007179 | Biological process | transforming growth factor beta receptor signaling pathway |
GO_1904262 | Biological process | negative regulation of TORC1 signaling |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0004707 | Molecular function | MAP kinase activity |
GO_0140297 | Molecular function | DNA-binding transcription factor binding |
GO_0106310 | Molecular function | protein serine kinase activity |
GO_0004674 | Molecular function | protein serine/threonine kinase activity |
GO_0031625 | Molecular function | ubiquitin protein ligase binding |
GO_0000287 | Molecular function | magnesium ion binding |
GO_0004672 | Molecular function | protein kinase activity |
GO_0042169 | Molecular function | SH2 domain binding |
GO_0005524 | Molecular function | ATP binding |
GO_0005515 | Molecular function | protein binding |
Gene name | NLK |
Protein name | Serine/threonine-protein kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1) Nemo like kinase Mitogen-activated protein kinase (EC 2.7.11.24) |
Synonyms | LAK1 |
Description | FUNCTION: Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination . Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2 . Negative regulator of the canonical Wnt/beta-catenin signaling pathway . Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1 . Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes . Negative regulator of the Notch signaling pathway . Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1 . Negative regulator of the MYB family of transcription factors . Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP . Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself . Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1 . Upon IL1B stimulus, cooperates with ATF5 to activate the transactivation activity of C/EBP subfamily members . Phosphorylates ATF5 but also stabilizes ATF5 protein levels in a kinase-independent manner . Acts as an inhibitor of the mTORC1 complex in response to osmotic stress by mediating phosphorylation of RPTOR, thereby preventing recruitment of the mTORC1 complex to lysosomes . . |
Accessions | ENST00000407008.8 ENST00000496808.1 J3QSE9 Q9UBE8 H0YD75 ENST00000582037.2 |