PPP1CB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006470Biological processprotein dephosphorylation
GO_0000165Biological processMAPK cascade
GO_0005977Biological processglycogen metabolic process
GO_0051301Biological processcell division
GO_0032922Biological processcircadian regulation of gene expression
GO_0042752Biological processregulation of circadian rhythm
GO_0043153Biological processentrainment of circadian clock by photoperiod
GO_0030155Biological processregulation of cell adhesion
GO_0005730Cellular componentnucleolus
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005925Cellular componentfocal adhesion
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0072357Cellular componentPTW/PP1 phosphatase complex
GO_0000781Cellular componentchromosome, telomeric region
GO_0005634Cellular componentnucleus
GO_0017018Molecular functionmyosin phosphatase activity
GO_0019901Molecular functionprotein kinase binding
GO_0050115Molecular functionmyosin-light-chain-phosphatase activity
GO_0046872Molecular functionmetal ion binding
GO_0004722Molecular functionprotein serine/threonine phosphatase activity
GO_0016791Molecular functionphosphatase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePPP1CB
Protein nameprotein-serine/threonine phosphatase (EC 3.1.3.16)
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53)
Protein phosphatase 1 catalytic subunit beta
Serine/threonine-protein phosphatase (EC 3.1.3.16)
Synonyms
DescriptionFUNCTION: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective . .

AccessionsENST00000395366.3
C9J9S3
C9JP48
ENST00000703171.1
ENST00000420282.5
ENST00000441461.6
B4DJ75
ENST00000703176.1
A0A8V8TQ71
ENST00000703172.1
ENST00000703174.1
F8WE71
P62140
H0Y3Y6
A0A8V8TR83
ENST00000427786.2
ENST00000455580.6
ENST00000418910.2
ENST00000703177.1
ENST00000703173.1
ENST00000420282.6
A0A8V8TRH9
ENST00000441461.5
ENST00000296122.10