IGFBP3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_0014912Biological processnegative regulation of smooth muscle cell migration
GO_0001558Biological processregulation of cell growth
GO_0000165Biological processMAPK cascade
GO_0009968Biological processnegative regulation of signal transduction
GO_0001649Biological processosteoblast differentiation
GO_0045663Biological processpositive regulation of myoblast differentiation
GO_0010906Biological processregulation of glucose metabolic process
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0001933Biological processnegative regulation of protein phosphorylation
GO_0043568Biological processpositive regulation of insulin-like growth factor receptor signaling pathway
GO_0048662Biological processnegative regulation of smooth muscle cell proliferation
GO_0006915Biological processapoptotic process
GO_0006468Biological processprotein phosphorylation
GO_0044342Biological processtype B pancreatic cell proliferation
GO_0043065Biological processpositive regulation of apoptotic process
GO_0043567Biological processregulation of insulin-like growth factor receptor signaling pathway
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0042567Cellular componentinsulin-like growth factor ternary complex
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0016942Cellular componentinsulin-like growth factor binding protein complex
GO_0005634Cellular componentnucleus
GO_0005520Molecular functioninsulin-like growth factor binding
GO_0001968Molecular functionfibronectin binding
GO_0031994Molecular functioninsulin-like growth factor I binding
GO_0031995Molecular functioninsulin-like growth factor II binding
GO_0008160Molecular functionprotein tyrosine phosphatase activator activity
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameIGFBP3
Protein nameInsulin like growth factor binding protein 3 (Insulin-like growth factor binding protein 3, isoform CRA_b) (cDNA FLJ43234 fis, clone HCHON2002964, highly similar to Insulin-like growth factor-binding protein 3)
Insulin-like growth factor-binding protein 3 (IBP-3) (IGF-binding protein 3) (IGFBP-3)
Insulin like growth factor binding protein 3
Insulin-like growth factor-binding protein 3
SynonymshCG_1735376
IBP3
DescriptionFUNCTION: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Inhibits the positive effect of humanin on insulin sensitivity . Promotes testicular germ cell apoptosis . .

AccessionsENST00000381086.9
ENST00000428530.5
ENST00000613132.5 [P17936-1]
ENST00000613132
A6XND0
ENST00000448817.1
B3KWK7
ENST00000381083.9 [P17936-2]
ENST00000417621.5
H0Y485
H0Y5K2
C9JMX4
P17936