MEN1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MEN1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MEN1 at tissue level.

III. Associated gene sets

GO_0030511Biological processpositive regulation of transforming growth factor beta receptor signaling pathway
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0006281Biological processDNA repair
GO_0045786Biological processnegative regulation of cell cycle
GO_0051974Biological processnegative regulation of telomerase activity
GO_0000165Biological processMAPK cascade
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0010332Biological processresponse to gamma radiation
GO_0006974Biological processDNA damage response
GO_0009411Biological processresponse to UV
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0043433Biological processnegative regulation of DNA-binding transcription factor activity
GO_0045064Biological processT-helper 2 cell differentiation
GO_0001933Biological processnegative regulation of protein phosphorylation
GO_0046329Biological processnegative regulation of JNK cascade
GO_0045668Biological processnegative regulation of osteoblast differentiation
GO_0045736Biological processnegative regulation of cyclin-dependent protein serine/threonine kinase activity
GO_0002076Biological processosteoblast development
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045815Biological processtranscription initiation-coupled chromatin remodeling
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0035097Cellular componenthistone methyltransferase complex
GO_0071339Cellular componentMLL1 complex
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0017053Cellular componenttranscription repressor complex
GO_0016363Cellular componentnuclear matrix
GO_0044665Cellular componentMLL1/2 complex
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0032154Cellular componentcleavage furrow
GO_0000781Cellular componentchromosome, telomeric region
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0070412Molecular functionR-SMAD binding
GO_0003682Molecular functionchromatin binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0000400Molecular functionfour-way junction DNA binding
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0000403Molecular functionY-form DNA binding
GO_0051219Molecular functionphosphoprotein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMEN1
Protein nameMenin 1
Truncated menin
Menin
SynonymsSCG2
DescriptionFUNCTION: Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair. .

AccessionsENST00000394376.7
ENST00000450708.7 [O00255-2]
ENST00000377313.7 [O00255-1]
ENST00000672079.2
ENST00000429702.5
C9DZM4
Q9GZQ5
ENST00000315422.9 [O00255-2]
Q7Z6F9
E7EN32
Q7Z5Y5
ENST00000377316.6
ENST00000440873.6 [O00255-2]
ENST00000429702.6 [O00255-2]
A0A5F9ZHS3
ENST00000424912.2 [O00255-2]
A0A8C8KI51
ENST00000413626.2 [O00255-2]
A0A8C8KI72
O00255
ENST00000312049.11 [O00255-2]
ENST00000710881.1 [O00255-1]
ENST00000394374.8
ENST00000424912.1
A0AA75I0P0
A0A5F9ZI68
ENST00000377326.7 [O00255-2]
ENST00000377321.5
ENST00000413626.1
ENST00000672304.1
E7ENS2