MAP3K11 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043507Biological processpositive regulation of JUN kinase activity
GO_0007254Biological processJNK cascade
GO_0000165Biological processMAPK cascade
GO_0046330Biological processpositive regulation of JNK cascade
GO_0007017Biological processmicrotubule-based process
GO_0043525Biological processpositive regulation of neuron apoptotic process
GO_0044843Biological processcell cycle G1/S phase transition
GO_0006468Biological processprotein phosphorylation
GO_0046777Biological processprotein autophosphorylation
GO_0043065Biological processpositive regulation of apoptotic process
GO_0005874Cellular componentmicrotubule
GO_0016020Cellular componentmembrane
GO_0005813Cellular componentcentrosome
GO_0005829Cellular componentcytosol
GO_0042803Molecular functionprotein homodimerization activity
GO_0031434Molecular functionmitogen-activated protein kinase kinase binding
GO_0106310Molecular functionprotein serine kinase activity
GO_0031435Molecular functionmitogen-activated protein kinase kinase kinase binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0042802Molecular functionidentical protein binding
GO_0031267Molecular functionsmall GTPase binding
GO_0004672Molecular functionprotein kinase activity
GO_0004709Molecular functionMAP kinase kinase kinase activity
GO_0004706Molecular functionJUN kinase kinase kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMAP3K11
Protein nameMitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase)
Mitogen-activated protein kinase kinase kinase 11
SynonymsPTK1
MLK3
SPRK
DescriptionFUNCTION: Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. .

AccessionsA0A139ZZA2
Q16584
E9PID4
ENST00000526293.1
ENST00000530153.5 [Q16584-2]
H0YCF5
E9PRQ2
ENST00000532507.5
ENST00000529839.1
ENST00000309100.8 [Q16584-1]
ENST00000524848.5
E9PLB1