Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 23 studies | 27% ± 13% | |
| capillary endothelial cell | 12 studies | 24% ± 12% | |
| endothelial cell of artery | 11 studies | 30% ± 15% | |
| non-classical monocyte | 10 studies | 26% ± 11% | |
| vein endothelial cell | 10 studies | 25% ± 11% | |
| endothelial cell of lymphatic vessel | 9 studies | 24% ± 8% | |
| classical monocyte | 9 studies | 27% ± 10% | |
| endothelial cell of vascular tree | 8 studies | 21% ± 5% | |
| macrophage | 6 studies | 22% ± 6% | |
| monocyte | 5 studies | 20% ± 3% | |
| epithelial cell | 5 studies | 30% ± 12% | |
| conventional dendritic cell | 3 studies | 32% ± 10% | |
| glomerular endothelial cell | 3 studies | 17% ± 1% | |
| myeloid cell | 3 studies | 24% ± 5% | |
| dendritic cell | 3 studies | 37% ± 12% | |
| oligodendrocyte | 3 studies | 21% ± 4% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| peripheral blood | 3 studies | 21% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 4435.14 | 1445 / 1445 | 100% | 40.62 | 183 / 183 |
| liver | 100% | 6342.46 | 226 / 226 | 100% | 38.17 | 406 / 406 |
| thymus | 100% | 5980.01 | 653 / 653 | 100% | 32.77 | 605 / 605 |
| skin | 100% | 4253.20 | 1808 / 1809 | 100% | 82.41 | 472 / 472 |
| uterus | 100% | 4791.25 | 170 / 170 | 100% | 27.46 | 458 / 459 |
| pancreas | 100% | 2744.68 | 327 / 328 | 100% | 31.75 | 178 / 178 |
| intestine | 100% | 5567.35 | 966 / 966 | 100% | 32.44 | 525 / 527 |
| kidney | 100% | 5674.74 | 89 / 89 | 100% | 32.06 | 897 / 901 |
| prostate | 100% | 5818.52 | 245 / 245 | 99% | 32.36 | 499 / 502 |
| stomach | 100% | 4023.19 | 359 / 359 | 99% | 33.91 | 284 / 286 |
| brain | 99% | 3120.36 | 2624 / 2642 | 100% | 20.26 | 703 / 705 |
| ovary | 99% | 2903.57 | 178 / 180 | 100% | 37.60 | 430 / 430 |
| breast | 100% | 6688.55 | 459 / 459 | 99% | 27.01 | 1105 / 1118 |
| lung | 100% | 9106.21 | 578 / 578 | 99% | 29.28 | 1139 / 1155 |
| bladder | 100% | 4317.95 | 21 / 21 | 98% | 32.56 | 495 / 504 |
| adrenal gland | 100% | 4180.33 | 258 / 258 | 97% | 21.48 | 224 / 230 |
| adipose | 100% | 6980.77 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 91.80 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 34.51 | 29 / 29 |
| spleen | 100% | 10701.93 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 28.98 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 37.52 | 1 / 1 |
| blood vessel | 99% | 3179.87 | 1327 / 1335 | 0% | 0 | 0 / 0 |
| heart | 99% | 3156.78 | 855 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 99% | 9286.40 | 922 / 929 | 0% | 0 | 0 / 0 |
| muscle | 88% | 1393.89 | 703 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0043507 | Biological process | positive regulation of JUN kinase activity |
| GO_0007254 | Biological process | JNK cascade |
| GO_0000165 | Biological process | MAPK cascade |
| GO_0046330 | Biological process | positive regulation of JNK cascade |
| GO_0007017 | Biological process | microtubule-based process |
| GO_0043525 | Biological process | positive regulation of neuron apoptotic process |
| GO_0044843 | Biological process | cell cycle G1/S phase transition |
| GO_0006468 | Biological process | protein phosphorylation |
| GO_0046777 | Biological process | protein autophosphorylation |
| GO_0043065 | Biological process | positive regulation of apoptotic process |
| GO_0005874 | Cellular component | microtubule |
| GO_0016020 | Cellular component | membrane |
| GO_0005813 | Cellular component | centrosome |
| GO_0005829 | Cellular component | cytosol |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0031434 | Molecular function | mitogen-activated protein kinase kinase binding |
| GO_0106310 | Molecular function | protein serine kinase activity |
| GO_0031435 | Molecular function | mitogen-activated protein kinase kinase kinase binding |
| GO_0004674 | Molecular function | protein serine/threonine kinase activity |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0031267 | Molecular function | small GTPase binding |
| GO_0004672 | Molecular function | protein kinase activity |
| GO_0004709 | Molecular function | MAP kinase kinase kinase activity |
| GO_0004706 | Molecular function | JUN kinase kinase kinase activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | MAP3K11 |
| Protein name | Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) Mitogen-activated protein kinase kinase kinase 11 |
| Synonyms | PTK1 MLK3 SPRK |
| Description | FUNCTION: Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. . |
| Accessions | A0A139ZZA2 Q16584 E9PID4 ENST00000526293.1 ENST00000530153.5 [Q16584-2] H0YCF5 E9PRQ2 ENST00000532507.5 ENST00000529839.1 ENST00000309100.8 [Q16584-1] ENST00000524848.5 E9PLB1 |