MAP4K4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046328Biological processregulation of JNK cascade
GO_0043547Biological processpositive regulation of GTPase activity
GO_0000165Biological processMAPK cascade
GO_0001953Biological processnegative regulation of cell-matrix adhesion
GO_0032014Biological processpositive regulation of ARF protein signal transduction
GO_0048812Biological processneuron projection morphogenesis
GO_0030033Biological processmicrovillus assembly
GO_0035332Biological processpositive regulation of hippo signaling
GO_0035556Biological processintracellular signal transduction
GO_0043066Biological processnegative regulation of apoptotic process
GO_0030335Biological processpositive regulation of cell migration
GO_0051549Biological processpositive regulation of keratinocyte migration
GO_0051894Biological processpositive regulation of focal adhesion assembly
GO_0120183Biological processpositive regulation of focal adhesion disassembly
GO_0006468Biological processprotein phosphorylation
GO_0043408Biological processregulation of MAPK cascade
GO_0005925Cellular componentfocal adhesion
GO_0005737Cellular componentcytoplasm
GO_0106310Molecular functionprotein serine kinase activity
GO_0008349Molecular functionMAP kinase kinase kinase kinase activity
GO_0004111Molecular functioncreatine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0008017Molecular functionmicrotubule binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMAP4K4
Protein nameMitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)
non-specific serine/threonine protein kinase (EC 2.7.11.1)
SynonymsHGK
KIAA0687
hCG_1640439
NIK
DescriptionFUNCTION: Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322. .

AccessionsENST00000427603.5
ENST00000418101.1
ENST00000634702.1 [O95819-4]
ENST00000625522.3 [O95819-2]
G5E948
E7ETN6
ENST00000417294.5
A0A0D9SEY1
ENST00000413150.6
O95819
ENST00000456652.5
ENST00000347699.8 [O95819-1]
ENST00000425019.6
ENST00000625522
E7EN19
Q5MD60
Q53TX8
ENST00000324219.9
Q53TW0
E7EX83
H7C0P6
H7C360
E7ENQ1
ENST00000421882.5
H7C3Z6
ENST00000350878.9 [O95819-6]