Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 42 studies | 39% ± 18% | |
| B cell | 24 studies | 28% ± 12% | |
| fibroblast | 23 studies | 32% ± 15% | |
| pericyte | 21 studies | 38% ± 16% | |
| astrocyte | 19 studies | 57% ± 18% | |
| smooth muscle cell | 18 studies | 29% ± 11% | |
| classical monocyte | 18 studies | 26% ± 11% | |
| macrophage | 16 studies | 32% ± 17% | |
| oligodendrocyte | 16 studies | 76% ± 17% | |
| microglial cell | 16 studies | 60% ± 20% | |
| oligodendrocyte precursor cell | 15 studies | 51% ± 17% | |
| glutamatergic neuron | 12 studies | 56% ± 25% | |
| endothelial cell of lymphatic vessel | 11 studies | 33% ± 16% | |
| capillary endothelial cell | 11 studies | 26% ± 12% | |
| myeloid cell | 11 studies | 29% ± 9% | |
| ciliated cell | 11 studies | 29% ± 13% | |
| GABAergic neuron | 10 studies | 57% ± 18% | |
| adipocyte | 10 studies | 38% ± 10% | |
| mast cell | 9 studies | 33% ± 16% | |
| naive B cell | 9 studies | 25% ± 7% | |
| neuron | 9 studies | 54% ± 24% | |
| endothelial cell of artery | 9 studies | 24% ± 5% | |
| vein endothelial cell | 9 studies | 29% ± 17% | |
| epithelial cell | 9 studies | 36% ± 17% | |
| dendritic cell | 9 studies | 36% ± 12% | |
| non-classical monocyte | 8 studies | 26% ± 12% | |
| memory B cell | 8 studies | 23% ± 7% | |
| plasmacytoid dendritic cell | 8 studies | 25% ± 10% | |
| T cell | 7 studies | 25% ± 8% | |
| monocyte | 7 studies | 31% ± 10% | |
| CD4-positive, alpha-beta T cell | 7 studies | 26% ± 5% | |
| retinal ganglion cell | 7 studies | 69% ± 19% | |
| natural killer cell | 6 studies | 20% ± 3% | |
| neutrophil | 6 studies | 26% ± 8% | |
| interneuron | 6 studies | 58% ± 11% | |
| mesothelial cell | 6 studies | 39% ± 8% | |
| type I pneumocyte | 6 studies | 25% ± 8% | |
| effector memory CD8-positive, alpha-beta T cell | 5 studies | 22% ± 4% | |
| myofibroblast cell | 5 studies | 29% ± 17% | |
| retinal bipolar neuron | 5 studies | 32% ± 12% | |
| amacrine cell | 5 studies | 26% ± 8% | |
| CD8-positive, alpha-beta T cell | 5 studies | 21% ± 4% | |
| cardiac muscle cell | 5 studies | 35% ± 5% | |
| lymphocyte | 5 studies | 36% ± 12% | |
| endothelial cell of vascular tree | 5 studies | 34% ± 18% | |
| club cell | 5 studies | 20% ± 4% | |
| type II pneumocyte | 5 studies | 21% ± 4% | |
| basal cell | 5 studies | 34% ± 19% | |
| naive thymus-derived CD4-positive, alpha-beta T cell | 4 studies | 28% ± 5% | |
| abnormal cell | 4 studies | 49% ± 27% | |
| glial cell | 4 studies | 44% ± 11% | |
| granule cell | 4 studies | 43% ± 11% | |
| retinal pigment epithelial cell | 4 studies | 38% ± 15% | |
| Mueller cell | 4 studies | 48% ± 14% | |
| ON-bipolar cell | 4 studies | 50% ± 18% | |
| regulatory T cell | 4 studies | 21% ± 6% | |
| conventional dendritic cell | 3 studies | 29% ± 7% | |
| hematopoietic precursor cell | 3 studies | 24% ± 6% | |
| differentiation-committed oligodendrocyte precursor | 3 studies | 72% ± 9% | |
| neural crest cell | 3 studies | 24% ± 1% | |
| GABAergic interneuron | 3 studies | 47% ± 16% | |
| progenitor cell | 3 studies | 52% ± 15% | |
| squamous epithelial cell | 3 studies | 39% ± 20% | |
| retina horizontal cell | 3 studies | 30% ± 20% | |
| mononuclear phagocyte | 3 studies | 26% ± 4% | |
| OFF-bipolar cell | 3 studies | 46% ± 20% | |
| glycinergic amacrine cell | 3 studies | 28% ± 13% | |
| rod bipolar cell | 3 studies | 52% ± 12% | |
| germinal center B cell | 3 studies | 26% ± 6% | |
| cholangiocyte | 3 studies | 51% ± 24% | |
| hepatocyte | 3 studies | 59% ± 22% | |
| pancreatic ductal cell | 3 studies | 34% ± 15% | |
| connective tissue cell | 3 studies | 36% ± 24% | |
| ependymal cell | 3 studies | 61% ± 19% | |
| leukocyte | 3 studies | 47% ± 23% | |
| alveolar macrophage | 3 studies | 32% ± 13% | |
| goblet cell | 3 studies | 30% ± 20% | |
| transit amplifying cell | 3 studies | 38% ± 28% | |
| mural cell | 3 studies | 48% ± 10% | |
| enteroendocrine cell | 3 studies | 21% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 25921.87 | 2642 / 2642 | 100% | 125.22 | 705 / 705 |
| skin | 100% | 14947.47 | 1804 / 1809 | 99% | 84.62 | 469 / 472 |
| esophagus | 100% | 6517.89 | 1444 / 1445 | 99% | 57.70 | 181 / 183 |
| lung | 99% | 8764.65 | 575 / 578 | 98% | 42.59 | 1137 / 1155 |
| uterus | 100% | 6856.82 | 170 / 170 | 97% | 43.48 | 447 / 459 |
| thymus | 99% | 5389.33 | 648 / 653 | 98% | 33.64 | 593 / 605 |
| breast | 100% | 10505.54 | 458 / 459 | 97% | 38.67 | 1088 / 1118 |
| prostate | 99% | 4739.03 | 242 / 245 | 97% | 24.07 | 488 / 502 |
| bladder | 100% | 6692.71 | 21 / 21 | 93% | 33.68 | 467 / 504 |
| intestine | 94% | 5803.31 | 907 / 966 | 96% | 29.28 | 505 / 527 |
| ovary | 100% | 6584.63 | 180 / 180 | 88% | 21.75 | 377 / 430 |
| liver | 88% | 3617.65 | 200 / 226 | 94% | 29.48 | 380 / 406 |
| stomach | 82% | 4055.22 | 293 / 359 | 97% | 33.55 | 278 / 286 |
| kidney | 69% | 3208.91 | 61 / 89 | 92% | 36.61 | 827 / 901 |
| pancreas | 34% | 1168.55 | 112 / 328 | 98% | 54.62 | 175 / 178 |
| adrenal gland | 57% | 1822.98 | 147 / 258 | 62% | 14.20 | 143 / 230 |
| adipose | 100% | 12194.26 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 42.99 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 53.88 | 29 / 29 |
| spleen | 100% | 6049.05 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 24.53 | 1 / 1 |
| blood vessel | 99% | 7140.08 | 1325 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 98% | 6771.69 | 790 / 803 | 0% | 0 | 0 / 0 |
| heart | 96% | 6451.72 | 828 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 96% | 35.89 | 43 / 45 |
| peripheral blood | 81% | 9837.54 | 751 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0046328 | Biological process | regulation of JNK cascade |
| GO_0043547 | Biological process | positive regulation of GTPase activity |
| GO_0000165 | Biological process | MAPK cascade |
| GO_0001953 | Biological process | negative regulation of cell-matrix adhesion |
| GO_0032014 | Biological process | positive regulation of ARF protein signal transduction |
| GO_0048812 | Biological process | neuron projection morphogenesis |
| GO_0030033 | Biological process | microvillus assembly |
| GO_0035332 | Biological process | positive regulation of hippo signaling |
| GO_0035556 | Biological process | intracellular signal transduction |
| GO_0043066 | Biological process | negative regulation of apoptotic process |
| GO_0030335 | Biological process | positive regulation of cell migration |
| GO_0051549 | Biological process | positive regulation of keratinocyte migration |
| GO_0051894 | Biological process | positive regulation of focal adhesion assembly |
| GO_0120183 | Biological process | positive regulation of focal adhesion disassembly |
| GO_0006468 | Biological process | protein phosphorylation |
| GO_0043408 | Biological process | regulation of MAPK cascade |
| GO_0005925 | Cellular component | focal adhesion |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0106310 | Molecular function | protein serine kinase activity |
| GO_0008349 | Molecular function | MAP kinase kinase kinase kinase activity |
| GO_0004111 | Molecular function | creatine kinase activity |
| GO_0004674 | Molecular function | protein serine/threonine kinase activity |
| GO_0008017 | Molecular function | microtubule binding |
| GO_0005524 | Molecular function | ATP binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | MAP4K4 |
| Protein name | Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase) non-specific serine/threonine protein kinase (EC 2.7.11.1) |
| Synonyms | HGK KIAA0687 hCG_1640439 NIK |
| Description | FUNCTION: Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322. . |
| Accessions | ENST00000427603.5 ENST00000418101.1 ENST00000634702.1 [O95819-4] ENST00000625522.3 [O95819-2] G5E948 E7ETN6 ENST00000417294.5 A0A0D9SEY1 ENST00000413150.6 O95819 ENST00000456652.5 ENST00000347699.8 [O95819-1] ENST00000425019.6 ENST00000625522 E7EN19 Q5MD60 Q53TX8 ENST00000324219.9 Q53TW0 E7EX83 H7C0P6 H7C360 E7ENQ1 ENST00000421882.5 H7C3Z6 ENST00000350878.9 [O95819-6] |