Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| mast cell | 13 studies | 26% ± 13% | |
| endothelial cell | 13 studies | 23% ± 6% | |
| fibroblast | 10 studies | 20% ± 5% | |
| macrophage | 9 studies | 20% ± 5% | |
| oligodendrocyte | 9 studies | 31% ± 10% | |
| epithelial cell | 8 studies | 37% ± 19% | |
| astrocyte | 8 studies | 28% ± 11% | |
| GABAergic neuron | 6 studies | 35% ± 15% | |
| classical monocyte | 5 studies | 26% ± 9% | |
| glutamatergic neuron | 5 studies | 47% ± 16% | |
| basal cell | 5 studies | 36% ± 20% | |
| ciliated cell | 5 studies | 27% ± 12% | |
| neuron | 4 studies | 35% ± 9% | |
| myeloid cell | 4 studies | 29% ± 8% | |
| adipocyte | 4 studies | 20% ± 2% | |
| hepatocyte | 4 studies | 44% ± 22% | |
| oligodendrocyte precursor cell | 4 studies | 28% ± 10% | |
| monocyte | 4 studies | 20% ± 5% | |
| hematopoietic precursor cell | 3 studies | 24% ± 9% | |
| retinal ganglion cell | 3 studies | 41% ± 18% | |
| amacrine cell | 3 studies | 36% ± 5% | |
| lymphocyte | 3 studies | 20% ± 3% | |
| pericyte | 3 studies | 18% ± 3% | |
| endothelial cell of vascular tree | 3 studies | 20% ± 7% | |
| dendritic cell | 3 studies | 22% ± 9% | |
| pancreatic A cell | 3 studies | 23% ± 5% | |
| alveolar macrophage | 3 studies | 23% ± 7% | |
| endothelial cell of lymphatic vessel | 3 studies | 21% ± 3% | |
| keratinocyte | 3 studies | 21% ± 4% | |
| interneuron | 3 studies | 47% ± 17% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 3346.44 | 1443 / 1445 | 100% | 85.80 | 183 / 183 |
| brain | 99% | 3028.12 | 2623 / 2642 | 100% | 34.69 | 703 / 705 |
| lung | 99% | 2201.01 | 572 / 578 | 100% | 45.57 | 1155 / 1155 |
| uterus | 100% | 2428.46 | 170 / 170 | 99% | 44.65 | 454 / 459 |
| bladder | 100% | 2504.05 | 21 / 21 | 98% | 34.96 | 496 / 504 |
| breast | 100% | 2165.31 | 459 / 459 | 98% | 31.76 | 1100 / 1118 |
| intestine | 100% | 2620.08 | 966 / 966 | 98% | 30.99 | 518 / 527 |
| prostate | 100% | 1827.82 | 245 / 245 | 98% | 31.32 | 493 / 502 |
| liver | 100% | 2718.29 | 226 / 226 | 98% | 26.46 | 398 / 406 |
| ovary | 100% | 1581.94 | 180 / 180 | 97% | 18.33 | 419 / 430 |
| stomach | 99% | 1737.86 | 357 / 359 | 98% | 30.47 | 279 / 286 |
| thymus | 100% | 2250.78 | 651 / 653 | 97% | 25.57 | 588 / 605 |
| kidney | 100% | 1801.03 | 89 / 89 | 96% | 19.99 | 867 / 901 |
| skin | 100% | 5193.98 | 1809 / 1809 | 92% | 26.63 | 433 / 472 |
| pancreas | 92% | 973.49 | 302 / 328 | 98% | 25.88 | 175 / 178 |
| adrenal gland | 100% | 1507.08 | 258 / 258 | 88% | 13.22 | 203 / 230 |
| ureter | 0% | 0 | 0 / 0 | 100% | 14.30 | 1 / 1 |
| muscle | 100% | 3696.43 | 802 / 803 | 0% | 0 | 0 / 0 |
| adipose | 100% | 2211.26 | 1200 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 100% | 1488.85 | 240 / 241 | 0% | 0 | 0 / 0 |
| blood vessel | 99% | 1647.92 | 1324 / 1335 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 57.63 | 44 / 45 |
| heart | 86% | 1105.86 | 742 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 76% | 14.02 | 22 / 29 |
| peripheral blood | 52% | 2567.66 | 480 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 51% | 6.61 | 41 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0007165 | Biological process | signal transduction |
| GO_0035556 | Biological process | intracellular signal transduction |
| GO_0006468 | Biological process | protein phosphorylation |
| GO_0000165 | Biological process | MAPK cascade |
| GO_0060999 | Biological process | positive regulation of dendritic spine development |
| GO_0032156 | Cellular component | septin cytoskeleton |
| GO_0032991 | Cellular component | protein-containing complex |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0046982 | Molecular function | protein heterodimerization activity |
| GO_0004707 | Molecular function | MAP kinase activity |
| GO_0019901 | Molecular function | protein kinase binding |
| GO_0004674 | Molecular function | protein serine/threonine kinase activity |
| GO_0106310 | Molecular function | protein serine kinase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0005524 | Molecular function | ATP binding |
| Gene name | MAPK6 |
| Protein name | Mitogen-activated protein kinase 6 (MAP kinase 6) (MAPK 6) (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97-MAPK) |
| Synonyms | ERK3 PRKM6 |
| Description | FUNCTION: Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity). . |
| Accessions | ENST00000680652.1 ENST00000261845.7 ENST00000681888.1 Q16659 ENST00000680777.1 ENST00000680066.1 ENST00000691380.1 |