TNIK | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
mast cell	27 studies	46% ± 23%	Explore
astrocyte	19 studies	75% ± 17%	Explore
oligodendrocyte	16 studies	40% ± 14%	Explore
oligodendrocyte precursor cell	16 studies	57% ± 19%	Explore
regulatory T cell	16 studies	28% ± 10%	Explore
natural killer cell	14 studies	26% ± 11%	Explore
glutamatergic neuron	13 studies	59% ± 24%	Explore
CD4-positive, alpha-beta T cell	13 studies	23% ± 7%	Explore
GABAergic neuron	11 studies	63% ± 21%	Explore
T cell	10 studies	29% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	23% ± 9%	Explore
microglial cell	8 studies	29% ± 16%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	21% ± 6%	Explore
endothelial cell	7 studies	37% ± 19%	Explore
CD8-positive, alpha-beta T cell	7 studies	27% ± 6%	Explore
mucosal invariant T cell	7 studies	23% ± 7%	Explore
fibroblast	7 studies	29% ± 8%	Explore
neuron	6 studies	50% ± 18%	Explore
interneuron	6 studies	65% ± 18%	Explore
retinal ganglion cell	6 studies	65% ± 21%	Explore
amacrine cell	6 studies	57% ± 25%	Explore
Mueller cell	6 studies	62% ± 27%	Explore
type II pneumocyte	6 studies	51% ± 11%	Explore
smooth muscle cell	6 studies	23% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	5 studies	25% ± 8%	Explore
macrophage	5 studies	28% ± 14%	Explore
cardiac muscle cell	5 studies	55% ± 12%	Explore
T follicular helper cell	5 studies	18% ± 2%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	22% ± 4%	Explore
mature NK T cell	4 studies	22% ± 11%	Explore
epithelial cell	4 studies	27% ± 9%	Explore
granule cell	4 studies	53% ± 21%	Explore
retinal rod cell	4 studies	38% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	18% ± 2%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	73% ± 11%	Explore
GABAergic interneuron	3 studies	71% ± 7%	Explore
pericyte	3 studies	36% ± 23%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	25% ± 3%	Explore
GABAergic amacrine cell	3 studies	73% ± 10%	Explore
ON-bipolar cell	3 studies	44% ± 12%	Explore
glycinergic amacrine cell	3 studies	70% ± 7%	Explore
abnormal cell	3 studies	30% ± 13%	Explore
cholangiocyte	3 studies	49% ± 16%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	21% ± 4%	Explore
ependymal cell	3 studies	72% ± 11%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	35% ± 14%	Explore
myeloid cell	3 studies	18% ± 1%	Explore
alveolar macrophage	3 studies	40% ± 5%	Explore
lymphocyte	3 studies	52% ± 10%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	22% ± 1%	Explore
gamma-delta T cell	3 studies	18% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	18 studies	52% ± 20%	Explore
eye	5 studies	41% ± 6%	Explore
heart	4 studies	29% ± 6%	Explore
lung	4 studies	30% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	4000.21	2641 / 2642	99%	32.68	700 / 705
thymus	99%	2095.71	644 / 653	94%	14.98	569 / 605
intestine	100%	2088.49	965 / 966	89%	10.96	468 / 527
kidney	85%	918.24	76 / 89	92%	11.16	826 / 901
stomach	90%	1048.12	324 / 359	86%	10.43	245 / 286
lung	100%	1976.45	577 / 578	71%	7.48	815 / 1155
pancreas	67%	458.57	221 / 328	91%	11.56	162 / 178
adrenal gland	96%	1331.40	248 / 258	60%	4.15	139 / 230
esophagus	87%	1916.85	1261 / 1445	64%	9.05	118 / 183
uterus	89%	912.58	152 / 170	53%	5.36	243 / 459
bladder	95%	1529.81	20 / 21	46%	4.29	232 / 504
breast	52%	482.19	239 / 459	73%	9.09	811 / 1118
prostate	87%	1151.40	212 / 245	28%	1.38	141 / 502
skin	30%	202.74	535 / 1809	78%	8.45	367 / 472
muscle	98%	1922.05	790 / 803	0%	0	0 / 0
spleen	93%	805.94	225 / 241	0%	0	0 / 0
blood vessel	93%	897.47	1239 / 1335	0%	0	0 / 0
heart	88%	1014.12	754 / 861	0%	0	0 / 0
liver	44%	299.14	100 / 226	27%	1.97	111 / 406
tonsil	0%	0	0 / 0	64%	4.91	29 / 45
peripheral blood	57%	1843.76	530 / 929	0%	0	0 / 0
ovary	26%	167.81	46 / 180	30%	2.19	130 / 430
lymph node	0%	0	0 / 0	45%	5.10	13 / 29
adipose	40%	235.80	481 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	3%	0.15	2 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0072659	Biological process	protein localization to plasma membrane
GO_0048814	Biological process	regulation of dendrite morphogenesis
GO_0000165	Biological process	MAPK cascade
GO_0046330	Biological process	positive regulation of JNK cascade
GO_0007010	Biological process	cytoskeleton organization
GO_0001934	Biological process	positive regulation of protein phosphorylation
GO_0048812	Biological process	neuron projection morphogenesis
GO_0030033	Biological process	microvillus assembly
GO_0030036	Biological process	actin cytoskeleton organization
GO_0035556	Biological process	intracellular signal transduction
GO_0010243	Biological process	response to organonitrogen compound
GO_0016055	Biological process	Wnt signaling pathway
GO_0006468	Biological process	protein phosphorylation
GO_0043408	Biological process	regulation of MAPK cascade
GO_0046777	Biological process	protein autophosphorylation
GO_0016324	Cellular component	apical plasma membrane
GO_0098978	Cellular component	glutamatergic synapse
GO_0098793	Cellular component	presynapse
GO_0005856	Cellular component	cytoskeleton
GO_0055037	Cellular component	recycling endosome
GO_0070062	Cellular component	extracellular exosome
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0099092	Cellular component	postsynaptic density, intracellular component
GO_0005634	Cellular component	nucleus
GO_0106310	Molecular function	protein serine kinase activity
GO_0004674	Molecular function	protein serine/threonine kinase activity
GO_0004672	Molecular function	protein kinase activity
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	TNIK
Protein name	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) non-specific serine/threonine protein kinase (EC 2.7.11.1)
Synonyms	KIAA0551
Description	FUNCTION: Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. .
Accessions	ENST00000357327.9 [Q9UKE5-2] ENST00000468757.1 ENST00000341852.10 [Q9UKE5-5] C9JVV1 C9J338 Q9UKE5 Q7Z4L4 ENST00000475336.5 [Q9UKE5-8] ENST00000488470.5 [Q9UKE5-3] ENST00000284483.12 [Q9UKE5-4] ENST00000470834.5 [Q9UKE5-6] ENST00000460047.5 [Q9UKE5-7] ENST00000436636.7 [Q9UKE5-1] ENST00000465393.1

TNIK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review