TAOK3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	38 studies	35% ± 18%	Explore
natural killer cell	33 studies	31% ± 9%	Explore
B cell	31 studies	26% ± 9%	Explore
conventional dendritic cell	27 studies	30% ± 12%	Explore
dendritic cell	23 studies	41% ± 20%	Explore
mast cell	23 studies	35% ± 15%	Explore
non-classical monocyte	23 studies	38% ± 13%	Explore
classical monocyte	23 studies	28% ± 9%	Explore
CD4-positive, alpha-beta T cell	23 studies	22% ± 6%	Explore
T cell	22 studies	26% ± 10%	Explore
CD8-positive, alpha-beta T cell	22 studies	24% ± 8%	Explore
regulatory T cell	21 studies	23% ± 6%	Explore
monocyte	20 studies	38% ± 18%	Explore
endothelial cell	19 studies	32% ± 13%	Explore
naive B cell	18 studies	21% ± 4%	Explore
astrocyte	18 studies	49% ± 22%	Explore
pericyte	18 studies	28% ± 11%	Explore
memory B cell	17 studies	21% ± 3%	Explore
microglial cell	16 studies	49% ± 17%	Explore
fibroblast	16 studies	25% ± 7%	Explore
oligodendrocyte	15 studies	47% ± 17%	Explore
oligodendrocyte precursor cell	15 studies	69% ± 18%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	29% ± 8%	Explore
mature NK T cell	15 studies	26% ± 7%	Explore
gamma-delta T cell	15 studies	27% ± 8%	Explore
myeloid cell	15 studies	39% ± 17%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	35% ± 6%	Explore
plasmacytoid dendritic cell	14 studies	34% ± 8%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	22% ± 5%	Explore
mucosal invariant T cell	12 studies	24% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	11 studies	22% ± 7%	Explore
type II pneumocyte	10 studies	38% ± 18%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	22% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	26% ± 7%	Explore
GABAergic neuron	10 studies	50% ± 21%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	30% ± 6%	Explore
epithelial cell	10 studies	35% ± 18%	Explore
leukocyte	9 studies	38% ± 14%	Explore
glutamatergic neuron	9 studies	55% ± 22%	Explore
hematopoietic stem cell	9 studies	44% ± 15%	Explore
adipocyte	9 studies	30% ± 6%	Explore
neuron	8 studies	37% ± 17%	Explore
retinal rod cell	8 studies	56% ± 18%	Explore
mononuclear phagocyte	7 studies	34% ± 15%	Explore
innate lymphoid cell	7 studies	27% ± 9%	Explore
retinal cone cell	7 studies	48% ± 14%	Explore
alveolar macrophage	7 studies	41% ± 21%	Explore
T follicular helper cell	7 studies	18% ± 1%	Explore
endothelial cell of lymphatic vessel	7 studies	30% ± 8%	Explore
smooth muscle cell	7 studies	22% ± 6%	Explore
hematopoietic precursor cell	6 studies	48% ± 22%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	24% ± 5%	Explore
interneuron	6 studies	53% ± 24%	Explore
club cell	6 studies	27% ± 6%	Explore
amacrine cell	6 studies	31% ± 8%	Explore
type I pneumocyte	6 studies	33% ± 7%	Explore
platelet	5 studies	21% ± 4%	Explore
retinal ganglion cell	5 studies	34% ± 8%	Explore
lymphocyte	5 studies	43% ± 12%	Explore
basal cell	5 studies	34% ± 25%	Explore
retina horizontal cell	5 studies	25% ± 6%	Explore
cardiac muscle cell	5 studies	31% ± 8%	Explore
ciliated cell	5 studies	21% ± 3%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	24% ± 7%	Explore
goblet cell	5 studies	31% ± 21%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	28% ± 8%	Explore
squamous epithelial cell	4 studies	32% ± 20%	Explore
exhausted T cell	4 studies	27% ± 10%	Explore
differentiation-committed oligodendrocyte precursor	4 studies	45% ± 12%	Explore
retinal bipolar neuron	4 studies	23% ± 5%	Explore
glial cell	4 studies	23% ± 9%	Explore
granule cell	4 studies	26% ± 6%	Explore
megakaryocyte	4 studies	35% ± 12%	Explore
plasma cell	4 studies	31% ± 10%	Explore
immature B cell	4 studies	22% ± 3%	Explore
ON-bipolar cell	4 studies	23% ± 5%	Explore
abnormal cell	4 studies	32% ± 14%	Explore
plasmablast	3 studies	37% ± 11%	Explore
GABAergic interneuron	3 studies	42% ± 3%	Explore
progenitor cell	3 studies	24% ± 5%	Explore
common myeloid progenitor	3 studies	40% ± 25%	Explore
pro-B cell	3 studies	21% ± 5%	Explore
retinal pigment epithelial cell	3 studies	25% ± 8%	Explore
tissue-resident macrophage	3 studies	35% ± 13%	Explore
OFF-bipolar cell	3 studies	21% ± 3%	Explore
rod bipolar cell	3 studies	30% ± 7%	Explore
germinal center B cell	3 studies	20% ± 1%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	23% ± 3%	Explore
endothelial cell of vascular tree	3 studies	28% ± 9%	Explore
hepatocyte	3 studies	53% ± 11%	Explore
muscle cell	3 studies	28% ± 13%	Explore
connective tissue cell	3 studies	27% ± 7%	Explore
ependymal cell	3 studies	39% ± 23%	Explore
granulocyte monocyte progenitor cell	3 studies	41% ± 22%	Explore
neutrophil	3 studies	32% ± 13%	Explore
group 3 innate lymphoid cell	3 studies	27% ± 10%	Explore
brush cell	3 studies	26% ± 2%	Explore
T-helper 17 cell	3 studies	20% ± 3%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	20% ± 1%	Explore
double negative thymocyte	3 studies	35% ± 9%	Explore
kidney loop of Henle epithelial cell	3 studies	26% ± 10%	Explore
mural cell	3 studies	40% ± 21%	Explore
mucus secreting cell	3 studies	30% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	19 studies	44% ± 21%	Explore
peripheral blood	15 studies	27% ± 8%	Explore
lung	12 studies	30% ± 10%	Explore
eye	8 studies	41% ± 15%	Explore
liver	6 studies	30% ± 12%	Explore
kidney	5 studies	23% ± 4%	Explore
bone marrow	4 studies	28% ± 8%	Explore
heart	4 studies	30% ± 5%	Explore
lymph node	4 studies	19% ± 3%	Explore
intestine	4 studies	20% ± 6%	Explore
adipose	4 studies	33% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2496.88	1445 / 1445	100%	20.05	183 / 183
intestine	100%	2769.23	966 / 966	100%	17.91	527 / 527
prostate	100%	2821.45	245 / 245	100%	38.92	502 / 502
brain	100%	4567.35	2641 / 2642	100%	35.01	705 / 705
stomach	100%	1995.09	359 / 359	100%	20.73	285 / 286
breast	100%	2463.26	459 / 459	99%	18.72	1108 / 1118
lung	100%	2916.80	578 / 578	99%	15.01	1142 / 1155
thymus	100%	2745.48	653 / 653	99%	16.65	597 / 605
bladder	100%	2473.52	21 / 21	98%	14.00	492 / 504
skin	100%	2917.49	1808 / 1809	96%	20.33	454 / 472
adrenal gland	99%	2318.25	256 / 258	96%	13.22	220 / 230
pancreas	95%	1027.01	311 / 328	98%	16.98	175 / 178
kidney	100%	1727.72	89 / 89	92%	13.56	830 / 901
uterus	100%	2373.48	170 / 170	92%	11.57	421 / 459
ovary	100%	2105.61	180 / 180	90%	7.66	388 / 430
liver	98%	1033.18	221 / 226	88%	8.85	359 / 406
adipose	100%	2643.68	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	18.71	29 / 29
spleen	100%	2329.78	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	5.85	1 / 1
blood vessel	100%	2321.01	1333 / 1335	0%	0	0 / 0
peripheral blood	99%	3554.42	918 / 929	0%	0	0 / 0
muscle	99%	1443.96	792 / 803	0%	0	0 / 0
heart	94%	1417.08	810 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	94%	19.80	75 / 80
tonsil	0%	0	0 / 0	89%	10.65	40 / 45
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0043507	Biological process	positive regulation of JUN kinase activity
GO_0006281	Biological process	DNA repair
GO_0032874	Biological process	positive regulation of stress-activated MAPK cascade
GO_0000165	Biological process	MAPK cascade
GO_0046330	Biological process	positive regulation of JNK cascade
GO_0006974	Biological process	DNA damage response
GO_0048812	Biological process	neuron projection morphogenesis
GO_0007095	Biological process	mitotic G2 DNA damage checkpoint signaling
GO_0046329	Biological process	negative regulation of JNK cascade
GO_0006468	Biological process	protein phosphorylation
GO_0043408	Biological process	regulation of MAPK cascade
GO_0046777	Biological process	protein autophosphorylation
GO_0005886	Cellular component	plasma membrane
GO_0005737	Cellular component	cytoplasm
GO_0004860	Molecular function	protein kinase inhibitor activity
GO_0106310	Molecular function	protein serine kinase activity
GO_0016740	Molecular function	transferase activity
GO_0004674	Molecular function	protein serine/threonine kinase activity
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	TAOK3
Protein name	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Cutaneous T-cell lymphoma-associated antigen HD-CL-09) (CTCL-associated antigen HD-CL-09) (Dendritic cell-derived protein kinase) (JNK/SAPK-inhibitory kinase) (Jun kinase-inhibitory kinase) (Kinase from chicken homolog A) (hKFC-A) (Thousand and one amino acid protein 3) TAO kinase 3 non-specific serine/threonine protein kinase (EC 2.7.11.1) Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3)
Synonyms	MAP3K18 DPK hCG_1812765 KDS JIK
Description	FUNCTION: Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF). .
Accessions	F5H1I2 F5H5C7 ENST00000541786.5 F5H005 H0YF68 ENST00000540561.5 F5GWV8 ENST00000535570.5 ENST00000542902.5 G3V1Q8 ENST00000537952.1 F5GY38 ENST00000539872.5 ENST00000537822.1 F5GX96 ENST00000538601.1 ENST00000392533.8 ENST00000541186.5 F5H0M3 ENST00000536979.1 ENST00000419821.6 F5H3L7 ENST00000541878.5 F5H7G4 F5H5E0 Q9H2K8 ENST00000542532.5

TAOK3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review