SPAG9 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	44 studies	39% ± 16%	Explore
macrophage	30 studies	31% ± 16%	Explore
fibroblast	30 studies	34% ± 13%	Explore
pericyte	25 studies	30% ± 14%	Explore
smooth muscle cell	22 studies	27% ± 8%	Explore
astrocyte	21 studies	48% ± 18%	Explore
classical monocyte	18 studies	29% ± 13%	Explore
oligodendrocyte	16 studies	52% ± 19%	Explore
oligodendrocyte precursor cell	15 studies	46% ± 19%	Explore
endothelial cell of lymphatic vessel	14 studies	36% ± 16%	Explore
monocyte	13 studies	31% ± 11%	Explore
conventional dendritic cell	13 studies	28% ± 13%	Explore
capillary endothelial cell	13 studies	28% ± 12%	Explore
microglial cell	13 studies	37% ± 13%	Explore
endothelial cell of vascular tree	13 studies	35% ± 17%	Explore
glutamatergic neuron	12 studies	45% ± 24%	Explore
endothelial cell of artery	12 studies	30% ± 11%	Explore
epithelial cell	12 studies	38% ± 21%	Explore
dendritic cell	11 studies	34% ± 13%	Explore
type I pneumocyte	11 studies	38% ± 14%	Explore
ciliated cell	11 studies	26% ± 15%	Explore
GABAergic neuron	11 studies	47% ± 21%	Explore
vein endothelial cell	11 studies	36% ± 22%	Explore
type II pneumocyte	10 studies	44% ± 15%	Explore
myeloid cell	10 studies	37% ± 11%	Explore
natural killer cell	9 studies	22% ± 4%	Explore
neutrophil	9 studies	26% ± 6%	Explore
neuron	9 studies	41% ± 17%	Explore
basal cell	9 studies	31% ± 17%	Explore
adipocyte	9 studies	37% ± 11%	Explore
B cell	8 studies	21% ± 2%	Explore
mast cell	8 studies	28% ± 7%	Explore
leukocyte	8 studies	25% ± 6%	Explore
connective tissue cell	8 studies	28% ± 6%	Explore
non-classical monocyte	7 studies	25% ± 8%	Explore
amacrine cell	7 studies	28% ± 7%	Explore
retinal ganglion cell	7 studies	39% ± 13%	Explore
retinal cone cell	7 studies	32% ± 9%	Explore
T cell	6 studies	24% ± 6%	Explore
interneuron	6 studies	59% ± 20%	Explore
club cell	6 studies	28% ± 10%	Explore
retina horizontal cell	6 studies	28% ± 6%	Explore
retinal rod cell	6 studies	20% ± 3%	Explore
secretory cell	6 studies	25% ± 7%	Explore
myofibroblast cell	6 studies	30% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	5 studies	18% ± 2%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	19% ± 2%	Explore
CD8-positive, alpha-beta T cell	5 studies	19% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	21% ± 3%	Explore
retinal bipolar neuron	5 studies	24% ± 2%	Explore
glial cell	5 studies	31% ± 13%	Explore
mesothelial cell	5 studies	29% ± 6%	Explore
lymphocyte	5 studies	38% ± 11%	Explore
regulatory T cell	5 studies	20% ± 5%	Explore
ionocyte	4 studies	23% ± 6%	Explore
mononuclear phagocyte	4 studies	35% ± 9%	Explore
CD16-positive, CD56-dim natural killer cell, human	4 studies	21% ± 1%	Explore
CD4-positive, alpha-beta T cell	4 studies	19% ± 2%	Explore
mature NK T cell	4 studies	21% ± 4%	Explore
granule cell	4 studies	38% ± 7%	Explore
retinal pigment epithelial cell	4 studies	47% ± 19%	Explore
cardiac muscle cell	4 studies	23% ± 3%	Explore
Mueller cell	4 studies	25% ± 9%	Explore
OFF-bipolar cell	4 studies	28% ± 6%	Explore
ON-bipolar cell	4 studies	28% ± 5%	Explore
abnormal cell	4 studies	27% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	21% ± 3%	Explore
gamma-delta T cell	4 studies	21% ± 3%	Explore
muscle cell	4 studies	36% ± 19%	Explore
brush cell	4 studies	41% ± 18%	Explore
epithelial cell of proximal tubule	4 studies	26% ± 11%	Explore
squamous epithelial cell	3 studies	44% ± 22%	Explore
naive B cell	3 studies	21% ± 3%	Explore
glomerular endothelial cell	3 studies	33% ± 4%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	53% ± 2%	Explore
GABAergic interneuron	3 studies	46% ± 6%	Explore
progenitor cell	3 studies	46% ± 10%	Explore
plasma cell	3 studies	27% ± 8%	Explore
GABAergic amacrine cell	3 studies	33% ± 10%	Explore
glycinergic amacrine cell	3 studies	30% ± 4%	Explore
rod bipolar cell	3 studies	34% ± 7%	Explore
respiratory goblet cell	3 studies	20% ± 5%	Explore
hepatocyte	3 studies	52% ± 15%	Explore
luminal cell of prostate epithelium	3 studies	28% ± 7%	Explore
pancreatic ductal cell	3 studies	35% ± 13%	Explore
ependymal cell	3 studies	68% ± 16%	Explore
enteroendocrine cell	3 studies	23% ± 3%	Explore
goblet cell	3 studies	40% ± 34%	Explore
adventitial cell	3 studies	29% ± 3%	Explore
alveolar macrophage	3 studies	38% ± 13%	Explore
chondrocyte	3 studies	37% ± 19%	Explore
melanocyte	3 studies	42% ± 21%	Explore
keratinocyte	3 studies	25% ± 2%	Explore
mural cell	3 studies	52% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	18 studies	47% ± 20%	Explore
lung	10 studies	32% ± 10%	Explore
eye	9 studies	30% ± 16%	Explore
peripheral blood	5 studies	28% ± 6%	Explore
heart	5 studies	25% ± 7%	Explore
kidney	5 studies	23% ± 8%	Explore
intestine	4 studies	23% ± 6%	Explore
uterus	4 studies	28% ± 9%	Explore
adipose	4 studies	35% ± 12%	Explore
placenta	3 studies	32% ± 14%	Explore
liver	3 studies	31% ± 13%	Explore
prostate	3 studies	23% ± 5%	Explore
skin	3 studies	25% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	7009.90	1445 / 1445	100%	38.16	183 / 183
brain	100%	11444.53	2642 / 2642	100%	95.87	704 / 705
lung	100%	11444.95	578 / 578	99%	31.55	1149 / 1155
kidney	100%	5749.97	89 / 89	99%	41.59	888 / 901
thymus	100%	9467.69	653 / 653	98%	33.31	595 / 605
breast	100%	8812.27	459 / 459	98%	31.54	1097 / 1118
bladder	100%	8529.95	21 / 21	98%	23.89	494 / 504
pancreas	100%	4545.02	328 / 328	98%	26.90	174 / 178
skin	100%	8779.64	1808 / 1809	97%	45.04	457 / 472
intestine	100%	7133.89	966 / 966	96%	21.31	507 / 527
uterus	100%	9296.19	170 / 170	95%	23.30	438 / 459
stomach	99%	4777.26	356 / 359	96%	23.55	275 / 286
prostate	100%	5618.52	244 / 245	95%	17.88	479 / 502
adrenal gland	100%	5968.66	258 / 258	92%	26.28	212 / 230
liver	100%	3201.07	225 / 226	80%	12.39	326 / 406
ovary	100%	9540.26	180 / 180	65%	8.04	279 / 430
adipose	100%	9931.36	1204 / 1204	0%	0	0 / 0
blood vessel	100%	9598.45	1335 / 1335	0%	0	0 / 0
muscle	100%	12604.74	803 / 803	0%	0	0 / 0
spleen	100%	4936.56	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	10.92	1 / 1
heart	97%	5129.79	837 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	23.63	43 / 45
eye	0%	0	0 / 0	91%	26.72	73 / 80
peripheral blood	89%	4109.78	827 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	83%	12.52	24 / 29
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000165	Biological process	MAPK cascade
GO_1903860	Biological process	negative regulation of dendrite extension
GO_0051146	Biological process	striated muscle cell differentiation
GO_0043410	Biological process	positive regulation of MAPK cascade
GO_0042147	Biological process	retrograde transport, endosome to Golgi
GO_0001933	Biological process	negative regulation of protein phosphorylation
GO_0016192	Biological process	vesicle-mediated transport
GO_0045665	Biological process	negative regulation of neuron differentiation
GO_0030335	Biological process	positive regulation of cell migration
GO_0032418	Biological process	lysosome localization
GO_0045666	Biological process	positive regulation of neuron differentiation
GO_0001669	Cellular component	acrosomal vesicle
GO_0034451	Cellular component	centriolar satellite
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005765	Cellular component	lysosomal membrane
GO_0008432	Molecular function	JUN kinase binding
GO_0005078	Molecular function	MAP-kinase scaffold activity
GO_0042802	Molecular function	identical protein binding
GO_0030159	Molecular function	signaling receptor complex adaptor activity
GO_0005515	Molecular function	protein binding
GO_0019894	Molecular function	kinesin binding

IV. Literature review

[source]

Gene name	SPAG9
Protein name	Sperm associated antigen 9 variant 5 C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) Sperm associated antigen 9
Synonyms	HLC6 SYD1 KIAA0516 MAPK8IP4 HSS
Description	FUNCTION: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module . Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex . Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). .
Accessions	ENST00000262013.12 [O60271-1] ENST00000510283.5 [O60271-9] ENST00000357122.8 [O60271-4] ENST00000513906.1 H0YBS5 ENST00000511795.1 A0A060L980 ENST00000505279.5 [O60271-2] H0YBE9 O60271 ENST00000510855.1 ENST00000513746.6 D6RHI8 H0Y981

SPAG9 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review