PPP1CC report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007283Biological processspermatogenesis
GO_0006470Biological processprotein dephosphorylation
GO_0000165Biological processMAPK cascade
GO_0060252Biological processpositive regulation of glial cell proliferation
GO_0005977Biological processglycogen metabolic process
GO_0051301Biological processcell division
GO_0032922Biological processcircadian regulation of gene expression
GO_0042752Biological processregulation of circadian rhythm
GO_0046822Biological processregulation of nucleocytoplasmic transport
GO_0030182Biological processneuron differentiation
GO_0043153Biological processentrainment of circadian clock by photoperiod
GO_0001824Biological processblastocyst development
GO_0098978Cellular componentglutamatergic synapse
GO_0005730Cellular componentnucleolus
GO_0098793Cellular componentpresynapse
GO_0030496Cellular componentmidbody
GO_0043197Cellular componentdendritic spine
GO_0005739Cellular componentmitochondrion
GO_0016607Cellular componentnuclear speck
GO_0000776Cellular componentkinetochore
GO_0005815Cellular componentmicrotubule organizing center
GO_0032991Cellular componentprotein-containing complex
GO_0005925Cellular componentfocal adhesion
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005741Cellular componentmitochondrial outer membrane
GO_0072357Cellular componentPTW/PP1 phosphatase complex
GO_0032154Cellular componentcleavage furrow
GO_0000781Cellular componentchromosome, telomeric region
GO_0005634Cellular componentnucleus
GO_0004721Molecular functionphosphoprotein phosphatase activity
GO_0019904Molecular functionprotein domain specific binding
GO_0017018Molecular functionmyosin phosphatase activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0019901Molecular functionprotein kinase binding
GO_0005521Molecular functionlamin binding
GO_0008157Molecular functionprotein phosphatase 1 binding
GO_0046872Molecular functionmetal ion binding
GO_0003723Molecular functionRNA binding
GO_0004722Molecular functionprotein serine/threonine phosphatase activity
GO_0016791Molecular functionphosphatase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePPP1CC
Protein nameprotein-serine/threonine phosphatase (EC 3.1.3.16)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit)
Serine/threonine-protein phosphatase (EC 3.1.3.16)
Synonyms
DescriptionFUNCTION: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective . .

AccessionsF8VR82
F8VYE8
ENST00000550261.5
P36873
F8W0W8
ENST00000551676.5
ENST00000551582.1
ENST00000335007.10 [P36873-1]
F8W0V8
ENST00000546933.5
ENST00000340766.9 [P36873-2]
ENST00000550991.5
Q9UPN1
F8W1A0
ENST00000620030.1
A0A087WYY5