RET | OmnibusX

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RET at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	94%	337.61	231 / 245	82%	13.74	411 / 502
adrenal gland	97%	1266.27	249 / 258	71%	245.83	163 / 230
breast	83%	248.02	382 / 459	81%	39.79	908 / 1118
brain	89%	558.95	2356 / 2642	72%	8.70	505 / 705
stomach	98%	388.72	352 / 359	22%	2.26	62 / 286
ovary	72%	84.88	129 / 180	46%	4.85	198 / 430
intestine	97%	584.83	941 / 966	20%	1.47	104 / 527
uterus	85%	155.42	144 / 170	24%	2.75	112 / 459
thymus	75%	178.66	491 / 653	22%	2.72	133 / 605
kidney	88%	194.07	78 / 89	5%	0.45	46 / 901
pancreas	70%	137.58	230 / 328	18%	1.12	32 / 178
adipose	86%	277.33	1033 / 1204	0%	0	0 / 0
esophagus	66%	239.16	956 / 1445	19%	1.41	35 / 183
liver	75%	312.95	169 / 226	8%	0.53	34 / 406
lung	49%	65.27	281 / 578	23%	4.06	266 / 1155
bladder	57%	90.29	12 / 21	10%	0.92	50 / 504
muscle	60%	146.68	478 / 803	0%	0	0 / 0
skin	54%	83.43	969 / 1809	3%	0.09	13 / 472
heart	44%	121.36	375 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	29%	2.65	13 / 45
blood vessel	17%	31.19	233 / 1335	0%	0	0 / 0
spleen	12%	13.81	29 / 241	0%	0	0 / 0
peripheral blood	4%	3.87	39 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	1%	0.11	1 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0071300	Biological process	cellular response to retinoic acid
GO_0033630	Biological process	positive regulation of cell adhesion mediated by integrin
GO_0001657	Biological process	ureteric bud development
GO_0033141	Biological process	positive regulation of peptidyl-serine phosphorylation of STAT protein
GO_0048484	Biological process	enteric nervous system development
GO_0007169	Biological process	cell surface receptor protein tyrosine kinase signaling pathway
GO_0010976	Biological process	positive regulation of neuron projection development
GO_0000165	Biological process	MAPK cascade
GO_0001755	Biological process	neural crest cell migration
GO_0033619	Biological process	membrane protein proteolysis
GO_0035860	Biological process	glial cell-derived neurotrophic factor receptor signaling pathway
GO_0007165	Biological process	signal transduction
GO_0010628	Biological process	positive regulation of gene expression
GO_0007275	Biological process	multicellular organism development
GO_0160144	Biological process	GDF15-GFRAL signaling pathway
GO_0060041	Biological process	retina development in camera-type eye
GO_0043410	Biological process	positive regulation of MAPK cascade
GO_0072300	Biological process	positive regulation of metanephric glomerulus development
GO_0001838	Biological process	embryonic epithelial tube formation
GO_0033674	Biological process	positive regulation of kinase activity
GO_0061146	Biological process	Peyer's patch morphogenesis
GO_0042551	Biological process	neuron maturation
GO_0097021	Biological process	lymphocyte migration into lymphoid organs
GO_0048265	Biological process	response to pain
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0030335	Biological process	positive regulation of cell migration
GO_0007156	Biological process	homophilic cell adhesion via plasma membrane adhesion molecules
GO_0035799	Biological process	ureter maturation
GO_0051897	Biological process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0014042	Biological process	positive regulation of neuron maturation
GO_0045793	Biological process	positive regulation of cell size
GO_0006468	Biological process	protein phosphorylation
GO_0009410	Biological process	response to xenobiotic stimulus
GO_2001241	Biological process	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO_0030155	Biological process	regulation of cell adhesion
GO_0007158	Biological process	neuron cell-cell adhesion
GO_0060384	Biological process	innervation
GO_0007411	Biological process	axon guidance
GO_0007497	Biological process	posterior midgut development
GO_0050770	Biological process	regulation of axonogenesis
GO_0043235	Cellular component	receptor complex
GO_0005886	Cellular component	plasma membrane
GO_0005769	Cellular component	early endosome
GO_0043025	Cellular component	neuronal cell body
GO_0030425	Cellular component	dendrite
GO_0098797	Cellular component	plasma membrane protein complex
GO_0010008	Cellular component	endosome membrane
GO_0030424	Cellular component	axon
GO_0038023	Molecular function	signaling receptor activity
GO_0004713	Molecular function	protein tyrosine kinase activity
GO_0004714	Molecular function	transmembrane receptor protein tyrosine kinase activity
GO_0005524	Molecular function	ATP binding
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	RET
Protein name	RET tyrosine kinase receptor RET proto-oncogene RET protein Alternative protein RET Ret proto-oncoprotein Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment] Ret proto-oncogene Ret proto-oncogene (Multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease), isoform CRA_c (cDNA FLJ58503, highly similar to Proto-oncogene tyrosine-protein kinase receptorret) Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) Receptor tyrosine kinase
Synonyms	CDHF12 RET51 hCG_22740 proto-oncogene CDHR16 PTC
Description	FUNCTION: Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regulated cell migration. Mediates, through interaction with GDF15-receptor GFRAL, GDF15-induced cell-signaling in the brainstem which induces inhibition of food-intake. Activates MAPK- and AKT-signaling pathways . Isoform 1 in complex with GFRAL induces higher activation of MAPK-signaling pathway than isoform 2 in complex with GFRAL . . FUNCTION: Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. . FUNCTION: Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. .
Accessions	Q9UE13 Q9BTX6 A0A804HL71 ENST00000671844.1 A0A1W2PSA1 ENST00000615310.5 Q9UMQ4 A0A5F9ZHR6 A0A087WWB1 ENST00000683278.1 ENST00000684216.1 ENST00000640619.1 Q8NFE8 ENST00000638465.1 F8TLS5 P07949 F8TLW0 A0A1W2PPN7 L8EA94 ENST00000355710.8 [P07949-1] Q99886 C9JYL6 ENST00000672389.1 Q8IZR8 M9Z0T2 Q9UM90 A0A804HIK7 ENST00000498820.5 B4DGX8 A0A5F9ZHB7 O43519 ENST00000340058.6 [P07949-2]

RET report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review