HSF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1903936Biological processcellular response to sodium arsenite
GO_0007584Biological processresponse to nutrient
GO_0033574Biological processresponse to testosterone
GO_0035865Biological processcellular response to potassium ion
GO_0006281Biological processDNA repair
GO_0045651Biological processpositive regulation of macrophage differentiation
GO_1902512Biological processpositive regulation of apoptotic DNA fragmentation
GO_2001033Biological processnegative regulation of double-strand break repair via nonhomologous end joining
GO_0031333Biological processnegative regulation of protein-containing complex assembly
GO_0071392Biological processcellular response to estradiol stimulus
GO_0014823Biological processresponse to activity
GO_0045931Biological processpositive regulation of mitotic cell cycle
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0070301Biological processcellular response to hydrogen peroxide
GO_1990910Biological processresponse to hypobaric hypoxia
GO_1904385Biological processcellular response to angiotensin
GO_0071466Biological processcellular response to xenobiotic stimulus
GO_0006397Biological processmRNA processing
GO_0000165Biological processMAPK cascade
GO_0010629Biological processnegative regulation of gene expression
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0010628Biological processpositive regulation of gene expression
GO_1990911Biological processresponse to psychosocial stress
GO_0071276Biological processcellular response to cadmium ion
GO_0071480Biological processcellular response to gamma radiation
GO_1900034Biological processregulation of cellular response to heat
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0010667Biological processnegative regulation of cardiac muscle cell apoptotic process
GO_0042531Biological processpositive regulation of tyrosine phosphorylation of STAT protein
GO_0090084Biological processnegative regulation of inclusion body assembly
GO_0034620Biological processcellular response to unfolded protein
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0051028Biological processmRNA transport
GO_1901652Biological processresponse to peptide
GO_0062029Biological processpositive regulation of stress granule assembly
GO_0072738Biological processcellular response to diamide
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0034605Biological processcellular response to heat
GO_1904843Biological processcellular response to nitroglycerin
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_1904845Biological processcellular response to L-glutamine
GO_0065003Biological processprotein-containing complex assembly
GO_0071280Biological processcellular response to copper ion
GO_0090261Biological processpositive regulation of inclusion body assembly
GO_0006952Biological processdefense response
GO_0016605Cellular componentPML body
GO_0005634Cellular componentnucleus
GO_0097431Cellular componentmitotic spindle pole
GO_0005654Cellular componentnucleoplasm
GO_1990904Cellular componentribonucleoprotein complex
GO_0097165Cellular componentnuclear stress granule
GO_0000792Cellular componentheterochromatin
GO_0005813Cellular componentcentrosome
GO_0000791Cellular componenteuchromatin
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0000776Cellular componentkinetochore
GO_0101031Cellular componentprotein folding chaperone complex
GO_0005829Cellular componentcytosol
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0051879Molecular functionHsp90 protein binding
GO_0042802Molecular functionidentical protein binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0031490Molecular functionchromatin DNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_1990841Molecular functionpromoter-specific chromatin binding
GO_0043565Molecular functionsequence-specific DNA binding
GO_0140296Molecular functiongeneral transcription initiation factor binding
GO_0098847Molecular functionsequence-specific single stranded DNA binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0031072Molecular functionheat shock protein binding
GO_0061770Molecular functiontranslation elongation factor binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0001162Molecular functionRNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
GO_0005515Molecular functionprotein binding
GO_0003677Molecular functionDNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0097677Molecular functionSTAT family protein binding
GO_0019901Molecular functionprotein kinase binding

IV. Literature review

[source]
Gene nameHSF1
Protein nameHeat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1)
Heat shock transcription factor 1
SynonymsHSTF1
DescriptionFUNCTION: Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones, heat shock proteins (HSPs), that protect cells from cellular insult damage . In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form . Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes . Upon heat shock stress, forms a chromatin-associated complex with TTC5/STRAP and p300/EP300 to stimulate HSR transcription, therefore increasing cell survival . Activation is reversible, and during the attenuation and recovery phase period of the HSR, returns to its unactivated form . Binds to inverted 5'-NGAAN-3' pentamer DNA sequences . Binds to chromatin at heat shock gene promoters . Activates transcription of transcription factor FOXR1 which in turn activates transcription of the heat shock chaperones HSPA1A and HSPA6 and the antioxidant NADPH-dependent reductase DHRS2 . Also serves several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells . Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner . Plays a role in nuclear export of stress-induced HSP70 mRNA . Plays a role in the regulation of mitotic progression . Also plays a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner . Involved in stress-induced cancer cell proliferation in a IER5-dependent manner . .; FUNCTION: (Microbial infection) Plays a role in latent human immunodeficiency virus (HIV-1) transcriptional reactivation. Binds to the HIV-1 long terminal repeat promoter (LTR) to reactivate viral transcription by recruiting cellular transcriptional elongation factors, such as CDK9, CCNT1 and EP300. .

AccessionsE9PMQ6
A0A087WXG6
ENST00000528988.1
ENST00000530661.1
ENST00000646252.2 [Q00613-1]
A0A087X1F9
E9PI02
A0A087WWQ3
Q00613
ENST00000533240.5
ENST00000534314.5
ENST00000528838.6 [Q00613-1]
ENST00000400780.8