IQGAP1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	48 studies	35% ± 13%	Explore
macrophage	43 studies	46% ± 18%	Explore
natural killer cell	40 studies	44% ± 14%	Explore
B cell	39 studies	32% ± 14%	Explore
pericyte	33 studies	28% ± 12%	Explore
CD8-positive, alpha-beta T cell	32 studies	33% ± 12%	Explore
CD4-positive, alpha-beta T cell	32 studies	28% ± 9%	Explore
T cell	31 studies	31% ± 12%	Explore
fibroblast	28 studies	28% ± 9%	Explore
classical monocyte	28 studies	60% ± 16%	Explore
conventional dendritic cell	28 studies	46% ± 19%	Explore
smooth muscle cell	25 studies	31% ± 11%	Explore
non-classical monocyte	24 studies	57% ± 15%	Explore
mast cell	23 studies	33% ± 13%	Explore
regulatory T cell	23 studies	37% ± 9%	Explore
dendritic cell	22 studies	52% ± 17%	Explore
monocyte	22 studies	53% ± 16%	Explore
memory B cell	20 studies	33% ± 10%	Explore
mature NK T cell	19 studies	37% ± 11%	Explore
naive B cell	19 studies	33% ± 11%	Explore
basal cell	19 studies	34% ± 17%	Explore
epithelial cell	19 studies	36% ± 18%	Explore
gamma-delta T cell	18 studies	40% ± 12%	Explore
ciliated cell	17 studies	37% ± 13%	Explore
myeloid cell	17 studies	49% ± 20%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	46% ± 13%	Explore
plasmacytoid dendritic cell	16 studies	34% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	53% ± 12%	Explore
endothelial cell of lymphatic vessel	15 studies	31% ± 12%	Explore
oligodendrocyte	15 studies	51% ± 18%	Explore
capillary endothelial cell	15 studies	28% ± 8%	Explore
mucosal invariant T cell	14 studies	35% ± 8%	Explore
endothelial cell of vascular tree	14 studies	30% ± 14%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	40% ± 9%	Explore
neutrophil	13 studies	42% ± 8%	Explore
type I pneumocyte	12 studies	39% ± 13%	Explore
type II pneumocyte	12 studies	42% ± 16%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	29% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	42% ± 9%	Explore
myofibroblast cell	12 studies	23% ± 7%	Explore
endothelial cell of artery	12 studies	34% ± 7%	Explore
club cell	11 studies	34% ± 15%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	11 studies	26% ± 7%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	29% ± 9%	Explore
vein endothelial cell	11 studies	32% ± 17%	Explore
secretory cell	10 studies	32% ± 10%	Explore
plasma cell	9 studies	23% ± 12%	Explore
leukocyte	9 studies	35% ± 11%	Explore
goblet cell	9 studies	29% ± 22%	Explore
astrocyte	9 studies	29% ± 14%	Explore
alveolar macrophage	8 studies	54% ± 16%	Explore
innate lymphoid cell	8 studies	35% ± 11%	Explore
plasmablast	8 studies	41% ± 24%	Explore
respiratory goblet cell	8 studies	35% ± 12%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	40% ± 12%	Explore
abnormal cell	8 studies	27% ± 11%	Explore
adipocyte	8 studies	26% ± 8%	Explore
mononuclear phagocyte	7 studies	44% ± 12%	Explore
precursor B cell	7 studies	38% ± 16%	Explore
mesothelial cell	7 studies	31% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	34% ± 10%	Explore
ionocyte	6 studies	39% ± 18%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	33% ± 10%	Explore
GABAergic neuron	6 studies	30% ± 14%	Explore
lymphocyte	6 studies	47% ± 12%	Explore
T follicular helper cell	6 studies	32% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	35% ± 9%	Explore
connective tissue cell	6 studies	29% ± 9%	Explore
exhausted T cell	5 studies	38% ± 8%	Explore
hematopoietic precursor cell	5 studies	40% ± 11%	Explore
transit amplifying cell	5 studies	33% ± 25%	Explore
pro-B cell	5 studies	32% ± 12%	Explore
brush cell	5 studies	34% ± 13%	Explore
immature B cell	5 studies	39% ± 11%	Explore
squamous epithelial cell	4 studies	44% ± 21%	Explore
glial cell	4 studies	21% ± 3%	Explore
intermediate monocyte	4 studies	63% ± 19%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	28% ± 9%	Explore
granulocyte	4 studies	29% ± 13%	Explore
muscle cell	4 studies	41% ± 13%	Explore
glutamatergic neuron	4 studies	51% ± 17%	Explore
T-helper 17 cell	4 studies	30% ± 9%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	34% ± 11%	Explore
double negative thymocyte	4 studies	39% ± 7%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	26% ± 7%	Explore
hillock cell	3 studies	30% ± 4%	Explore
platelet	3 studies	29% ± 10%	Explore
pancreatic A cell	3 studies	42% ± 20%	Explore
glomerular endothelial cell	3 studies	29% ± 1%	Explore
renal alpha-intercalated cell	3 studies	18% ± 2%	Explore
microglial cell	3 studies	25% ± 9%	Explore
extravillous trophoblast	3 studies	42% ± 15%	Explore
progenitor cell	3 studies	27% ± 1%	Explore
serous secreting cell	3 studies	22% ± 8%	Explore
tissue-resident macrophage	3 studies	57% ± 11%	Explore
inflammatory macrophage	3 studies	45% ± 9%	Explore
CD4-positive helper T cell	3 studies	40% ± 12%	Explore
IgG plasma cell	3 studies	16% ± 2%	Explore
luminal cell of prostate epithelium	3 studies	23% ± 3%	Explore
pancreatic ductal cell	3 studies	64% ± 25%	Explore
ependymal cell	3 studies	30% ± 14%	Explore
enteroendocrine cell	3 studies	22% ± 2%	Explore
adventitial cell	3 studies	25% ± 1%	Explore
group 3 innate lymphoid cell	3 studies	40% ± 12%	Explore
Schwann cell	3 studies	31% ± 11%	Explore
keratinocyte	3 studies	25% ± 4%	Explore
T-helper 1 cell	3 studies	33% ± 5%	Explore
cardiac muscle cell	3 studies	19% ± 2%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	27% ± 6%	Explore
mural cell	3 studies	43% ± 10%	Explore
mucus secreting cell	3 studies	35% ± 8%	Explore
renal principal cell	3 studies	35% ± 10%	Explore
erythrocyte	3 studies	22% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	20 studies	34% ± 14%	Explore
peripheral blood	19 studies	42% ± 14%	Explore
brain	13 studies	34% ± 17%	Explore
intestine	7 studies	21% ± 3%	Explore
kidney	6 studies	27% ± 9%	Explore
heart	5 studies	24% ± 6%	Explore
uterus	5 studies	36% ± 12%	Explore
adipose	5 studies	34% ± 9%	Explore
breast	5 studies	24% ± 7%	Explore
placenta	4 studies	35% ± 19%	Explore
bone marrow	4 studies	38% ± 11%	Explore
lymph node	4 studies	28% ± 6%	Explore
prostate	4 studies	19% ± 2%	Explore
liver	4 studies	27% ± 6%	Explore
pancreas	3 studies	44% ± 24%	Explore
skin	3 studies	23% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	16301.11	1445 / 1445	100%	159.44	183 / 183
lung	100%	18094.36	578 / 578	100%	113.00	1155 / 1155
breast	100%	15720.83	459 / 459	100%	134.79	1116 / 1118
intestine	100%	14187.60	966 / 966	99%	97.76	524 / 527
ovary	100%	10560.78	180 / 180	99%	81.42	426 / 430
thymus	100%	13598.68	653 / 653	99%	114.07	598 / 605
uterus	100%	23775.84	170 / 170	98%	87.46	452 / 459
bladder	100%	16137.90	21 / 21	98%	78.27	495 / 504
stomach	99%	8261.04	354 / 359	99%	103.44	284 / 286
skin	100%	21604.52	1809 / 1809	97%	114.30	459 / 472
prostate	100%	9780.47	245 / 245	97%	55.38	486 / 502
kidney	99%	7430.34	88 / 89	96%	75.95	865 / 901
adrenal gland	100%	10681.74	257 / 258	89%	41.96	204 / 230
pancreas	87%	4613.51	286 / 328	98%	89.62	175 / 178
brain	55%	2504.72	1441 / 2642	63%	28.07	444 / 705
adipose	100%	17958.00	1204 / 1204	0%	0	0 / 0
blood vessel	100%	24305.13	1335 / 1335	0%	0	0 / 0
spleen	100%	12418.12	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	100.49	45 / 45
ureter	0%	0	0 / 0	100%	19.50	1 / 1
peripheral blood	99%	23415.17	920 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	68.03	28 / 29
muscle	91%	5875.13	730 / 803	0%	0	0 / 0
heart	84%	4876.94	726 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	78%	44.59	62 / 80
liver	7%	254.48	15 / 226	20%	10.18	83 / 406
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000165	Biological process	MAPK cascade
GO_0071364	Biological process	cellular response to epidermal growth factor stimulus
GO_0007165	Biological process	signal transduction
GO_0010761	Biological process	fibroblast migration
GO_1903479	Biological process	mitotic actomyosin contractile ring assembly actin filament organization
GO_0043410	Biological process	positive regulation of MAPK cascade
GO_0035305	Biological process	negative regulation of dephosphorylation
GO_0045860	Biological process	positive regulation of protein kinase activity
GO_0048008	Biological process	platelet-derived growth factor receptor signaling pathway
GO_0071277	Biological process	cellular response to calcium ion
GO_0007346	Biological process	regulation of mitotic cell cycle
GO_0001817	Biological process	regulation of cytokine production
GO_0072015	Biological process	podocyte development
GO_0007173	Biological process	epidermal growth factor receptor signaling pathway
GO_1990138	Biological process	neuron projection extension
GO_0016477	Biological process	cell migration
GO_0036120	Biological process	cellular response to platelet-derived growth factor stimulus
GO_0008543	Biological process	fibroblast growth factor receptor signaling pathway
GO_0001726	Cellular component	ruffle
GO_0016324	Cellular component	apical plasma membrane
GO_0030667	Cellular component	secretory granule membrane
GO_0036057	Cellular component	slit diaphragm
GO_0030496	Cellular component	midbody
GO_0005886	Cellular component	plasma membrane
GO_0005874	Cellular component	microtubule
GO_0036464	Cellular component	cytoplasmic ribonucleoprotein granule
GO_0009898	Cellular component	cytoplasmic side of plasma membrane
GO_0070062	Cellular component	extracellular exosome
GO_0030864	Cellular component	cortical actin cytoskeleton
GO_0043005	Cellular component	neuron projection
GO_0005884	Cellular component	actin filament
GO_0005925	Cellular component	focal adhesion
GO_0015629	Cellular component	actin cytoskeleton
GO_0005829	Cellular component	cytosol
GO_0005938	Cellular component	cell cortex
GO_0015630	Cellular component	microtubule cytoskeleton
GO_0030426	Cellular component	growth cone
GO_0016328	Cellular component	lateral plasma membrane
GO_0005737	Cellular component	cytoplasm
GO_0030424	Cellular component	axon
GO_1990904	Cellular component	ribonucleoprotein complex
GO_0016323	Cellular component	basolateral plasma membrane
GO_0005634	Cellular component	nucleus
GO_0005547	Molecular function	phosphatidylinositol-3,4,5-trisphosphate binding
GO_0019904	Molecular function	protein domain specific binding
GO_0060090	Molecular function	molecular adaptor activity
GO_0005078	Molecular function	MAP-kinase scaffold activity
GO_0019903	Molecular function	protein phosphatase binding
GO_0005095	Molecular function	GTPase inhibitor activity
GO_0045296	Molecular function	cadherin binding
GO_0019901	Molecular function	protein kinase binding
GO_0051015	Molecular function	actin filament binding
GO_0031267	Molecular function	small GTPase binding
GO_0005096	Molecular function	GTPase activator activity
GO_0043539	Molecular function	protein serine/threonine kinase activator activity
GO_0044548	Molecular function	S100 protein binding
GO_0005516	Molecular function	calmodulin binding
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	IQGAP1
Protein name	IQ motif containing GTPase activating protein 1 IQGAP1 protein Ras GTPase-activating-like protein IQGAP1 (p195)
Synonyms	KIAA0051
Description	FUNCTION: Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth . May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest . .
Accessions	ENST00000633485.1 A0A087WWP1 A0A087X225 A4QPB0 Q5FWG8 ENST00000560738.1 ENST00000559809.2 Q6P1N4 ENST00000560418.1 P46940 A0A0J9YXZ5 ENST00000268182.10 Q05DN7 ENST00000560373.1 H0YLE8 H0YKA5

IQGAP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review