FGFR1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	45 studies	36% ± 16%	Explore
endothelial cell	30 studies	29% ± 14%	Explore
smooth muscle cell	20 studies	27% ± 7%	Explore
oligodendrocyte precursor cell	14 studies	45% ± 20%	Explore
astrocyte	14 studies	36% ± 12%	Explore
pericyte	14 studies	24% ± 6%	Explore
endothelial cell of lymphatic vessel	12 studies	21% ± 4%	Explore
connective tissue cell	12 studies	37% ± 17%	Explore
myofibroblast cell	11 studies	29% ± 8%	Explore
capillary endothelial cell	10 studies	21% ± 5%	Explore
adipocyte	9 studies	30% ± 7%	Explore
vein endothelial cell	8 studies	18% ± 4%	Explore
macrophage	6 studies	27% ± 8%	Explore
glutamatergic neuron	5 studies	33% ± 18%	Explore
adventitial cell	5 studies	36% ± 14%	Explore
cardiac muscle cell	5 studies	23% ± 5%	Explore
Mueller cell	5 studies	33% ± 12%	Explore
endothelial cell of vascular tree	5 studies	23% ± 4%	Explore
pancreatic A cell	4 studies	37% ± 22%	Explore
GABAergic neuron	4 studies	33% ± 17%	Explore
abnormal cell	4 studies	33% ± 24%	Explore
myoepithelial cell	4 studies	36% ± 14%	Explore
glomerular endothelial cell	3 studies	24% ± 6%	Explore
endothelial cell of artery	3 studies	25% ± 2%	Explore
epithelial cell	3 studies	42% ± 20%	Explore
mesothelial cell	3 studies	27% ± 7%	Explore
muscle cell	3 studies	30% ± 8%	Explore
ependymal cell	3 studies	40% ± 14%	Explore
chondrocyte	3 studies	36% ± 7%	Explore
neuron	3 studies	44% ± 14%	Explore
enteroendocrine cell	3 studies	22% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	7 studies	24% ± 6%	Explore
heart	5 studies	20% ± 2%	Explore
uterus	3 studies	24% ± 5%	Explore
breast	3 studies	25% ± 8%	Explore
adipose	3 studies	28% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	100%	22214.68	180 / 180	96%	39.86	412 / 430
breast	100%	19463.51	459 / 459	95%	40.20	1057 / 1118
pancreas	100%	12757.30	328 / 328	93%	23.61	166 / 178
prostate	100%	13970.01	244 / 245	93%	15.91	465 / 502
kidney	99%	6917.46	88 / 89	92%	21.71	825 / 901
brain	89%	7093.81	2351 / 2642	98%	24.83	691 / 705
skin	94%	9501.49	1692 / 1809	84%	28.51	396 / 472
thymus	98%	8012.87	640 / 653	78%	12.51	469 / 605
lung	100%	11632.12	576 / 578	75%	16.36	871 / 1155
uterus	99%	18006.00	169 / 170	55%	25.37	251 / 459
esophagus	91%	14270.01	1308 / 1445	54%	11.86	98 / 183
bladder	100%	17488.81	21 / 21	44%	9.06	221 / 504
intestine	93%	14901.48	894 / 966	45%	7.18	236 / 527
adrenal gland	40%	1570.40	104 / 258	93%	39.56	215 / 230
stomach	61%	7205.23	218 / 359	53%	8.83	153 / 286
adipose	100%	20262.54	1204 / 1204	0%	0	0 / 0
blood vessel	100%	22430.58	1335 / 1335	0%	0	0 / 0
heart	99%	11946.62	854 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	72%	8.72	21 / 29
eye	0%	0	0 / 0	65%	8.98	52 / 80
muscle	63%	2364.90	508 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	44%	9.55	20 / 45
spleen	29%	1023.90	70 / 241	0%	0	0 / 0
liver	6%	226.42	13 / 226	19%	4.34	76 / 406
peripheral blood	6%	326.44	52 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0001759	Biological process	organ induction
GO_0010976	Biological process	positive regulation of neuron projection development
GO_0090272	Biological process	negative regulation of fibroblast growth factor production
GO_0002062	Biological process	chondrocyte differentiation
GO_0007275	Biological process	multicellular organism development
GO_0043009	Biological process	chordate embryonic development
GO_1905564	Biological process	positive regulation of vascular endothelial cell proliferation
GO_0001764	Biological process	neuron migration
GO_0048015	Biological process	phosphatidylinositol-mediated signaling
GO_0002053	Biological process	positive regulation of mesenchymal cell proliferation
GO_0001501	Biological process	skeletal system development
GO_0051897	Biological process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0010518	Biological process	positive regulation of phospholipase activity
GO_0006468	Biological process	protein phosphorylation
GO_0035607	Biological process	fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
GO_0010966	Biological process	regulation of phosphate transport
GO_0042473	Biological process	outer ear morphogenesis
GO_0072089	Biological process	stem cell proliferation
GO_0060665	Biological process	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO_0001525	Biological process	angiogenesis
GO_0001657	Biological process	ureteric bud development
GO_0001701	Biological process	in utero embryonic development
GO_0000165	Biological process	MAPK cascade
GO_0031175	Biological process	neuron projection development
GO_0070640	Biological process	vitamin D3 metabolic process
GO_0045595	Biological process	regulation of cell differentiation
GO_0030326	Biological process	embryonic limb morphogenesis
GO_0010463	Biological process	mesenchymal cell proliferation
GO_0060117	Biological process	auditory receptor cell development
GO_0042472	Biological process	inner ear morphogenesis
GO_0010467	Biological process	gene expression
GO_0042474	Biological process	middle ear morphogenesis
GO_0046777	Biological process	protein autophosphorylation
GO_0060484	Biological process	lung-associated mesenchyme development
GO_0048705	Biological process	skeletal system morphogenesis
GO_0008543	Biological process	fibroblast growth factor receptor signaling pathway
GO_0071344	Biological process	diphosphate metabolic process
GO_0007605	Biological process	sensory perception of sound
GO_0060445	Biological process	branching involved in salivary gland morphogenesis
GO_0043536	Biological process	positive regulation of blood vessel endothelial cell migration
GO_0060045	Biological process	positive regulation of cardiac muscle cell proliferation
GO_1903465	Biological process	positive regulation of mitotic cell cycle DNA replication
GO_0043406	Biological process	positive regulation of MAP kinase activity
GO_0060038	Biological process	cardiac muscle cell proliferation
GO_0033674	Biological process	positive regulation of kinase activity
GO_0021847	Biological process	ventricular zone neuroblast division
GO_0045597	Biological process	positive regulation of cell differentiation
GO_2001028	Biological process	positive regulation of endothelial cell chemotaxis
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0048469	Biological process	cell maturation
GO_0016477	Biological process	cell migration
GO_0030901	Biological process	midbrain development
GO_0055074	Biological process	calcium ion homeostasis
GO_0048378	Biological process	regulation of lateral mesodermal cell fate specification
GO_0001837	Biological process	epithelial to mesenchymal transition
GO_0007169	Biological process	cell surface receptor protein tyrosine kinase signaling pathway
GO_2000830	Biological process	positive regulation of parathyroid hormone secretion
GO_0048339	Biological process	paraxial mesoderm development
GO_0030031	Biological process	cell projection assembly
GO_2000648	Biological process	positive regulation of stem cell proliferation
GO_2001239	Biological process	regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO_0043410	Biological process	positive regulation of MAPK cascade
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_1904383	Biological process	response to sodium phosphate
GO_0018108	Biological process	peptidyl-tyrosine phosphorylation
GO_0071529	Biological process	cementum mineralization
GO_0090080	Biological process	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO_0048863	Biological process	stem cell differentiation
GO_0045666	Biological process	positive regulation of neuron differentiation
GO_0044344	Biological process	cellular response to fibroblast growth factor stimulus
GO_0005634	Cellular component	nucleus
GO_0005576	Cellular component	extracellular region
GO_0043235	Cellular component	receptor complex
GO_0005886	Cellular component	plasma membrane
GO_0031410	Cellular component	cytoplasmic vesicle
GO_0016020	Cellular component	membrane
GO_0005829	Cellular component	cytosol
GO_0042802	Molecular function	identical protein binding
GO_0042169	Molecular function	SH2 domain binding
GO_0005524	Molecular function	ATP binding
GO_0090722	Molecular function	receptor-receptor interaction
GO_0008201	Molecular function	heparin binding
GO_0004713	Molecular function	protein tyrosine kinase activity
GO_0005515	Molecular function	protein binding
GO_0042803	Molecular function	protein homodimerization activity
GO_0005007	Molecular function	fibroblast growth factor receptor activity
GO_0017134	Molecular function	fibroblast growth factor binding

IV. Literature review

[source]

Gene name	FGFR1
Protein name	Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331) Fibroblast growth factor receptor 1 isoform 4 Fibroblast growth factor receptor 1 receptor protein-tyrosine kinase (EC 2.7.10.1) Fibroblast growth factor receptor 1 isoform 3 Soluble FGFR1 variant 2 Fibroblast growth factor receptor 1 (EC 2.7.10.1) Fibroblast growth factor receptor 1 (Soluble FGFR1 variant 1) Fibroblast growth factor receptor (EC 2.7.10.1)
Synonyms	BFGFR FLG CEK FLT2 HBGFR FGFBR hCG_23105
Description	FUNCTION: Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. .
Accessions	E7EU09 ENST00000525001.5 ENST00000530568.5 E9PNM3 P11362 E9PN14 A0A0S2Z3P8 A0A6I8PRY1 ENST00000356207.9 [P11362-3] ENST00000674235.1 A0A3B3ISD1 E9PQ40 A0A8I3B1S4 ENST00000425967.8 ENST00000683765.1 ENST00000434187.5 E9PKX3 ENST00000531196.5 ENST00000447712.7 [P11362-1] A0A994J419 ENST00000397091.9 [P11362-7] ENST00000397113.6 [P11362-7] ENST00000532791.5 [P11362-2] ENST00000397103.5 B5A959 H0YE20 A0A1V1G971 ENST00000703405.1 E9PKF2 ENST00000619564.3 A0A0S2Z3Q6 A0A1V1G4T2 E9PKV7 ENST00000487647.5 ENST00000533668.5 ENST00000674380.1 A0A0S2Z3T9 A0A0S2Z3P4 ENST00000526742.5 ENST00000413133.6 ENST00000341462.9 ENST00000335922.9 [P11362-20] A0A1B0RPQ4 ENST00000649678.1 A0A804HIF1 ENST00000529552.5 A0A6I8PTV4 ENST00000684654.1 A0A0S2Z3T4 ENST00000674189.1 B5A958 ENST00000397108.8 [P11362-7] C9J205 ENST00000326324.10 [P11362-14] ENST00000484370.5 [P11362-15] C9J1L5 C1KBH7 ENST00000683815.1

FGFR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review