YWHAE report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051480Biological processregulation of cytosolic calcium ion concentration
GO_0021766Biological processhippocampus development
GO_0034605Biological processcellular response to heat
GO_0000165Biological processMAPK cascade
GO_0007165Biological processsignal transduction
GO_1902309Biological processnegative regulation of peptidyl-serine dephosphorylation
GO_0046827Biological processpositive regulation of protein export from nucleus
GO_0001764Biological processneuron migration
GO_1901016Biological processregulation of potassium ion transmembrane transporter activity
GO_0086013Biological processmembrane repolarization during cardiac muscle cell action potential
GO_0006605Biological processprotein targeting
GO_0070972Biological processprotein localization to endoplasmic reticulum
GO_0060306Biological processregulation of membrane repolarization
GO_0035332Biological processpositive regulation of hippo signaling
GO_0051220Biological processcytoplasmic sequestering of protein
GO_0035556Biological processintracellular signal transduction
GO_0003064Biological processregulation of heart rate by hormone
GO_0034504Biological processprotein localization to nucleus
GO_0007346Biological processregulation of mitotic cell cycle
GO_0086091Biological processregulation of heart rate by cardiac conduction
GO_0021762Biological processsubstantia nigra development
GO_0034122Biological processnegative regulation of toll-like receptor signaling pathway
GO_0008104Biological processprotein localization
GO_0021987Biological processcerebral cortex development
GO_1905913Biological processnegative regulation of calcium ion export across plasma membrane
GO_0002753Biological processcytoplasmic pattern recognition receptor signaling pathway
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0031966Cellular componentmitochondrial membrane
GO_0070062Cellular componentextracellular exosome
GO_0005925Cellular componentfocal adhesion
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0042470Cellular componentmelanosome
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0019904Molecular functionprotein domain specific binding
GO_0019903Molecular functionprotein phosphatase binding
GO_0045296Molecular functioncadherin binding
GO_0005246Molecular functioncalcium channel regulator activity
GO_0042802Molecular functionidentical protein binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0097110Molecular functionscaffold protein binding
GO_0035591Molecular functionsignaling adaptor activity
GO_0015459Molecular functionpotassium channel regulator activity
GO_0044325Molecular functiontransmembrane transporter binding
GO_0003723Molecular functionRNA binding
GO_0019855Molecular functioncalcium channel inhibitor activity
GO_0046982Molecular functionprotein heterodimerization activity
GO_0023026Molecular functionMHC class II protein complex binding
GO_0140311Molecular functionprotein sequestering activity
GO_0051219Molecular functionphosphoprotein binding
GO_0050815Molecular functionphosphoserine residue binding
GO_0005515Molecular functionprotein binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameYWHAE
Protein name14-3-3 protein epsilon
14-3-3 protein epsilon (Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon)
14-3-3 protein epsilon (14-3-3E)
Synonyms
DescriptionFUNCTION: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif . Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm . Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI . Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signaling during viral infection . Plays a role in proliferation inhibition and cell cycle arrest by exporting HNRNPC from the nucleus to the cytoplasm to be degraded by ubiquitination . .

AccessionsENST00000575977.1
ENST00000573196.5
ENST00000571732.5 [P62258-2]
ENST00000616643.3 [P62258-2]
P62258
ENST00000466227.6
ENST00000573026.1
ENST00000627231.2 [P62258-1]
ENST00000496706.1
B4DJF2
I3L3T1
I3L0W5
ENST00000626999.1
ENST00000264335.13 [P62258-1]
K7EIT4
K7EM20
ENST00000628106.1
ENST00000629090.2
ENST00000628059.1
ENST00000630606.2