ARAF report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ARAF at tissue level.

III. Associated gene sets

GO_0033138Biological processpositive regulation of peptidyl-serine phosphorylation
GO_0032434Biological processregulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0043066Biological processnegative regulation of apoptotic process
GO_0036211Biological processprotein modification process
GO_0032006Biological processregulation of TOR signaling
GO_0000165Biological processMAPK cascade
GO_0005575Cellular componentcellular_component
GO_0005829Cellular componentcytosol
GO_0005739Cellular componentmitochondrion
GO_0004709Molecular functionMAP kinase kinase kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0005515Molecular functionprotein binding
GO_0004672Molecular functionprotein kinase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameARAF
Protein namenon-specific serine/threonine protein kinase (EC 2.7.11.1)
Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks)
SynonymshCG_29140
PKS2
PKS
ARAF1
DescriptionFUNCTION: Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Phosphorylates PFKFB2 . .; FUNCTION: [Isoform 2]: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. .

AccessionsQ96II5
ENST00000377045.9 [P10398-1]
A0A024R178
ENST00000377039.2 [P10398-2]
P10398
A0A0S2Z3F2