Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 11 studies | 28% ± 11% | |
| oligodendrocyte precursor cell | 10 studies | 31% ± 15% | |
| glutamatergic neuron | 9 studies | 37% ± 25% | |
| astrocyte | 8 studies | 30% ± 13% | |
| GABAergic neuron | 7 studies | 40% ± 21% | |
| macrophage | 7 studies | 23% ± 6% | |
| fibroblast | 7 studies | 21% ± 6% | |
| oligodendrocyte | 7 studies | 29% ± 9% | |
| interneuron | 6 studies | 40% ± 24% | |
| neuron | 5 studies | 32% ± 15% | |
| microglial cell | 5 studies | 26% ± 6% | |
| granule cell | 4 studies | 23% ± 8% | |
| epithelial cell | 4 studies | 37% ± 13% | |
| cardiac muscle cell | 4 studies | 20% ± 3% | |
| lymphocyte | 4 studies | 22% ± 6% | |
| endothelial cell of lymphatic vessel | 4 studies | 25% ± 5% | |
| GABAergic interneuron | 3 studies | 23% ± 4% | |
| ciliated cell | 3 studies | 27% ± 7% | |
| glycinergic amacrine cell | 3 studies | 31% ± 12% | |
| type I pneumocyte | 3 studies | 23% ± 6% | |
| pericyte | 3 studies | 21% ± 4% | |
| transit amplifying cell | 3 studies | 32% ± 21% | |
| smooth muscle cell | 3 studies | 18% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 2545.15 | 1445 / 1445 | 100% | 20.95 | 183 / 183 |
| prostate | 100% | 3256.21 | 245 / 245 | 100% | 18.06 | 502 / 502 |
| uterus | 100% | 4010.93 | 170 / 170 | 100% | 20.15 | 459 / 459 |
| thymus | 100% | 2560.89 | 653 / 653 | 100% | 13.66 | 603 / 605 |
| breast | 100% | 2502.36 | 459 / 459 | 100% | 17.06 | 1114 / 1118 |
| intestine | 100% | 2574.11 | 966 / 966 | 100% | 12.37 | 525 / 527 |
| bladder | 100% | 2482.24 | 21 / 21 | 100% | 13.10 | 502 / 504 |
| pancreas | 100% | 1395.22 | 328 / 328 | 99% | 12.93 | 177 / 178 |
| lung | 100% | 2164.28 | 577 / 578 | 99% | 14.07 | 1149 / 1155 |
| stomach | 100% | 1670.69 | 359 / 359 | 99% | 12.19 | 284 / 286 |
| brain | 99% | 1873.00 | 2620 / 2642 | 100% | 15.64 | 705 / 705 |
| kidney | 100% | 1638.18 | 89 / 89 | 97% | 10.43 | 875 / 901 |
| adrenal gland | 100% | 1415.28 | 258 / 258 | 95% | 10.48 | 218 / 230 |
| ovary | 100% | 3164.50 | 180 / 180 | 94% | 7.95 | 404 / 430 |
| skin | 100% | 2970.18 | 1809 / 1809 | 90% | 8.45 | 424 / 472 |
| liver | 100% | 952.26 | 226 / 226 | 87% | 6.32 | 354 / 406 |
| adipose | 100% | 2149.77 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 12.91 | 29 / 29 |
| spleen | 100% | 2265.24 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 19.71 | 45 / 45 |
| blood vessel | 100% | 2157.16 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 100% | 2152.29 | 802 / 803 | 0% | 0 | 0 / 0 |
| heart | 98% | 1624.90 | 846 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 69% | 1316.69 | 643 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 69% | 4.41 | 55 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0043507 | Biological process | positive regulation of JUN kinase activity |
| GO_0010468 | Biological process | regulation of gene expression |
| GO_0060718 | Biological process | chorionic trophoblast cell differentiation |
| GO_1904355 | Biological process | positive regulation of telomere capping |
| GO_0000165 | Biological process | MAPK cascade |
| GO_0010225 | Biological process | response to UV-C |
| GO_1900745 | Biological process | positive regulation of p38MAPK cascade |
| GO_0001890 | Biological process | placenta development |
| GO_0035556 | Biological process | intracellular signal transduction |
| GO_0051973 | Biological process | positive regulation of telomerase activity |
| GO_0019100 | Biological process | male germ-line sex determination |
| GO_0032212 | Biological process | positive regulation of telomere maintenance via telomerase |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0106310 | Molecular function | protein serine kinase activity |
| GO_0004709 | Molecular function | MAP kinase kinase kinase activity |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0005524 | Molecular function | ATP binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | MAP3K4 |
| Protein name | Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAP three kinase 1) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) Mitogen-activated protein kinase kinase kinase 4 |
| Synonyms | MAPKKK4 MEKK4 MTK1 KIAA0213 |
| Description | FUNCTION: Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6. . |
| Accessions | J3KNB8 ENST00000348824.11 ENST00000544041.5 F5H2S6 ENST00000542952.5 F5H534 F5H1X6 F5H4R1 ENST00000490904.6 ENST00000448119.2 ENST00000366919.6 [Q9Y6R4-2] ENST00000366920.6 ENST00000392142.9 [Q9Y6R4-1] Q9Y6R4 F5H538 |