MAP3K9 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_0006468Biological processprotein phosphorylation
GO_0046777Biological processprotein autophosphorylation
GO_0043065Biological processpositive regulation of apoptotic process
GO_0000165Biological processMAPK cascade
GO_0005575Cellular componentcellular_component
GO_0042803Molecular functionprotein homodimerization activity
GO_0140677Molecular functionmolecular function activator activity
GO_0004706Molecular functionJUN kinase kinase kinase activity
GO_0004708Molecular functionMAP kinase kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0005515Molecular functionprotein binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameMAP3K9
Protein nameMitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1)
Mitogen-activated protein kinase kinase kinase 9
Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25)
SynonymsMLK1
PRKE1
DescriptionFUNCTION: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Also plays a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. .

AccessionsENST00000554146.1
G3V4P9
G3V347
J3KPI6
ENST00000381250.8
ENST00000555993.6 [P80192-4]
ENST00000553414.5
P80192
ENST00000554752.7 [P80192-1]