MAPKAPK3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0044351Biological processmacropinocytosis
GO_0002224Biological processtoll-like receptor signaling pathway
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0000165Biological processMAPK cascade
GO_0034097Biological processresponse to cytokine
GO_0007165Biological processsignal transduction
GO_0035556Biological processintracellular signal transduction
GO_0048010Biological processvascular endothelial growth factor receptor signaling pathway
GO_0046777Biological processprotein autophosphorylation
GO_0032496Biological processresponse to lipopolysaccharide
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0009931Molecular functioncalcium-dependent protein serine/threonine kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0004708Molecular functionMAP kinase kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0051019Molecular functionmitogen-activated protein kinase binding
GO_0005524Molecular functionATP binding
GO_0004683Molecular functioncalmodulin-dependent protein kinase activity
GO_0005516Molecular functioncalmodulin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMAPKAPK3
Protein nameMAPK activated protein kinase 3
Mitogen-activated protein kinase-activated protein kinase 3
MAP kinase-activated protein kinase 3 (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAP-K3) (MAPKAPK-3) (MK-3) (EC 2.7.11.1) (Chromosome 3p kinase) (3pK)
Synonyms
DescriptionFUNCTION: Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. Also acts as a modulator of Polycomb-mediated repression. .

AccessionsENST00000357955.6
Q16644
ENST00000451680.1
ENST00000621469.5
ENST00000457064.1
C9JPW3
B5BUJ8
C9J8E1
ENST00000430409.5
H7C0G6
ENST00000446044.5