Name | Number of supported studies | Average coverage | |
---|---|---|---|
non-classical monocyte | 20 studies | 42% ± 18% | |
classical monocyte | 13 studies | 30% ± 12% | |
monocyte | 10 studies | 24% ± 8% | |
plasmacytoid dendritic cell | 10 studies | 26% ± 6% | |
regulatory T cell | 7 studies | 23% ± 6% | |
CD4-positive, alpha-beta T cell | 6 studies | 22% ± 6% | |
myeloid cell | 6 studies | 21% ± 5% | |
hematopoietic precursor cell | 5 studies | 36% ± 10% | |
dendritic cell | 5 studies | 34% ± 18% | |
natural killer cell | 5 studies | 17% ± 2% | |
hematopoietic stem cell | 4 studies | 23% ± 4% | |
macrophage | 4 studies | 23% ± 5% | |
CD16-negative, CD56-bright natural killer cell, human | 3 studies | 16% ± 1% | |
conventional dendritic cell | 3 studies | 39% ± 9% | |
common myeloid progenitor | 3 studies | 33% ± 12% | |
effector CD4-positive, alpha-beta T cell | 3 studies | 22% ± 5% | |
granulocyte monocyte progenitor cell | 3 studies | 38% ± 7% | |
megakaryocyte-erythroid progenitor cell | 3 studies | 28% ± 16% | |
CD8-positive, alpha-beta T cell | 3 studies | 25% ± 4% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
peripheral blood | 5 studies | 20% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
thymus | 100% | 4722.11 | 653 / 653 | 100% | 144.46 | 605 / 605 |
skin | 100% | 5067.99 | 1808 / 1809 | 100% | 55.01 | 471 / 472 |
esophagus | 100% | 2875.80 | 1439 / 1445 | 100% | 32.68 | 183 / 183 |
kidney | 100% | 3803.85 | 89 / 89 | 100% | 68.61 | 897 / 901 |
stomach | 99% | 2410.94 | 357 / 359 | 100% | 48.66 | 286 / 286 |
pancreas | 99% | 2395.02 | 326 / 328 | 100% | 38.53 | 178 / 178 |
prostate | 100% | 2333.98 | 244 / 245 | 100% | 63.01 | 500 / 502 |
lung | 98% | 3244.96 | 569 / 578 | 100% | 46.70 | 1153 / 1155 |
ovary | 98% | 1545.63 | 176 / 180 | 100% | 37.02 | 430 / 430 |
breast | 97% | 1845.65 | 446 / 459 | 99% | 45.97 | 1112 / 1118 |
intestine | 96% | 1626.64 | 930 / 966 | 99% | 55.44 | 524 / 527 |
adrenal gland | 100% | 4796.52 | 258 / 258 | 95% | 41.55 | 218 / 230 |
bladder | 95% | 1737.57 | 20 / 21 | 99% | 49.48 | 497 / 504 |
uterus | 93% | 1317.31 | 158 / 170 | 99% | 41.62 | 455 / 459 |
liver | 89% | 1311.27 | 202 / 226 | 93% | 25.58 | 377 / 406 |
brain | 61% | 803.41 | 1619 / 2642 | 99% | 37.88 | 698 / 705 |
eye | 0% | 0 | 0 / 0 | 100% | 35.80 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 49.45 | 29 / 29 |
muscle | 100% | 14407.12 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 2994.01 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 37.51 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 27.50 | 1 / 1 |
heart | 99% | 14172.55 | 855 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 99% | 4986.13 | 917 / 929 | 0% | 0 | 0 / 0 |
adipose | 96% | 1822.10 | 1157 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 83% | 1243.59 | 1105 / 1335 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0044351 | Biological process | macropinocytosis |
GO_0002224 | Biological process | toll-like receptor signaling pathway |
GO_0018105 | Biological process | peptidyl-serine phosphorylation |
GO_0000165 | Biological process | MAPK cascade |
GO_0034097 | Biological process | response to cytokine |
GO_0007165 | Biological process | signal transduction |
GO_0035556 | Biological process | intracellular signal transduction |
GO_0048010 | Biological process | vascular endothelial growth factor receptor signaling pathway |
GO_0046777 | Biological process | protein autophosphorylation |
GO_0032496 | Biological process | response to lipopolysaccharide |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0009931 | Molecular function | calcium-dependent protein serine/threonine kinase activity |
GO_0106310 | Molecular function | protein serine kinase activity |
GO_0004708 | Molecular function | MAP kinase kinase activity |
GO_0004674 | Molecular function | protein serine/threonine kinase activity |
GO_0051019 | Molecular function | mitogen-activated protein kinase binding |
GO_0005524 | Molecular function | ATP binding |
GO_0004683 | Molecular function | calmodulin-dependent protein kinase activity |
GO_0005516 | Molecular function | calmodulin binding |
GO_0005515 | Molecular function | protein binding |
Gene name | MAPKAPK3 |
Protein name | MAPK activated protein kinase 3 Mitogen-activated protein kinase-activated protein kinase 3 MAP kinase-activated protein kinase 3 (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAP-K3) (MAPKAPK-3) (MK-3) (EC 2.7.11.1) (Chromosome 3p kinase) (3pK) |
Synonyms | |
Description | FUNCTION: Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. Also acts as a modulator of Polycomb-mediated repression. . |
Accessions | ENST00000357955.6 Q16644 ENST00000451680.1 ENST00000621469.5 ENST00000457064.1 C9JPW3 B5BUJ8 C9J8E1 ENST00000430409.5 H7C0G6 ENST00000446044.5 |