MAP3K15 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MAP3K15 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MAP3K15 at tissue level.

III. Associated gene sets

GO_0033554Biological processcellular response to stress
GO_0000165Biological processMAPK cascade
GO_0004709Molecular functionMAP kinase kinase kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameMAP3K15
Protein nameMitogen-activated protein kinase kinase kinase 15
Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 3) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15)
SynonymsASK3
DescriptionFUNCTION: Serine/threonine kinase which acts as a component of the MAP kinase signal transduction pathway . Once activated, acts as an upstream activator of the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases . May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis . Involved in phosphorylation of WNK4 in response to osmotic stress or hypotonic low-chloride stimulation via the p38 MAPK signal transduction cascade . .

AccessionsENST00000338883.9 [Q6ZN16-1]
ENST00000359173.7
A0A140T8W5
Q6ZN16