ZDHHC9 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0141111Biological processpositive regulation of cGAS/STING signaling pathway
GO_0018345Biological processprotein palmitoylation
GO_0018230Biological processpeptidyl-L-cysteine S-palmitoylation
GO_0006612Biological processprotein targeting to membrane
GO_0044794Biological processpositive regulation by host of viral process
GO_0000165Biological processMAPK cascade
GO_0033116Cellular componentendoplasmic reticulum-Golgi intermediate compartment membrane
GO_0000139Cellular componentGolgi membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0002178Cellular componentpalmitoyltransferase complex
GO_0005794Cellular componentGolgi apparatus
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0016409Molecular functionpalmitoyltransferase activity
GO_0019706Molecular functionprotein-cysteine S-palmitoyltransferase activity
GO_0043849Molecular functionRas palmitoyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameZDHHC9
Protein namePalmitoyltransferase ZDHHC9 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 9) (DHHC-9) (DHHC9) (Zinc finger protein 379) (Zinc finger protein 380)
Palmitoyltransferase (EC 2.3.1.225)
SynonymsZNF379
CXorf11
UNQ261/PRO298
CGI-89
ZDHHC10
ZNF380
DescriptionFUNCTION: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as ADRB2, HRAS, NRAS and CGAS . The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS . May have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling . Acts as a regulator of innate immunity by catalyzing palmitoylation of CGAS, thereby promoting CGAS homodimerization and cyclic GMP-AMP synthase activity . .; FUNCTION: (Microbial infection) Through a sequential action with ZDHHC20, rapidly and efficiently palmitoylates SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell. .

AccessionsQ5JYE8
ENST00000357166.11
ENST00000433917.5
H0Y6K6
ENST00000371064.7
Q9Y397
ENST00000406492.2