Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 9 studies | 30% ± 19% | |
endothelial cell | 8 studies | 31% ± 15% | |
microglial cell | 7 studies | 35% ± 17% | |
oligodendrocyte precursor cell | 7 studies | 31% ± 13% | |
oligodendrocyte | 7 studies | 32% ± 17% | |
GABAergic neuron | 6 studies | 41% ± 23% | |
monocyte | 6 studies | 25% ± 7% | |
interneuron | 5 studies | 37% ± 21% | |
pericyte | 5 studies | 19% ± 4% | |
macrophage | 4 studies | 27% ± 8% | |
retinal cone cell | 4 studies | 26% ± 10% | |
fibroblast | 4 studies | 25% ± 12% | |
GABAergic interneuron | 3 studies | 23% ± 10% | |
neuron | 3 studies | 31% ± 10% | |
ciliated cell | 3 studies | 27% ± 2% | |
lymphocyte | 3 studies | 18% ± 2% | |
retinal rod cell | 3 studies | 19% ± 3% | |
retinal pigment epithelial cell | 3 studies | 28% ± 1% | |
glutamatergic neuron | 3 studies | 58% ± 4% | |
alveolar macrophage | 3 studies | 27% ± 6% | |
basal cell | 3 studies | 29% ± 12% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 6 studies | 43% ± 15% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 3022.48 | 1442 / 1445 | 98% | 9.45 | 180 / 183 |
brain | 99% | 2472.41 | 2611 / 2642 | 97% | 11.69 | 687 / 705 |
pancreas | 100% | 11258.76 | 328 / 328 | 95% | 5.98 | 169 / 178 |
lung | 100% | 4855.28 | 578 / 578 | 94% | 8.77 | 1088 / 1155 |
thymus | 100% | 6636.44 | 653 / 653 | 92% | 7.15 | 556 / 605 |
kidney | 100% | 4225.99 | 89 / 89 | 90% | 18.01 | 815 / 901 |
intestine | 100% | 2514.33 | 966 / 966 | 89% | 4.58 | 468 / 527 |
uterus | 100% | 5449.34 | 170 / 170 | 86% | 7.03 | 393 / 459 |
adrenal gland | 100% | 3162.86 | 258 / 258 | 83% | 4.52 | 192 / 230 |
stomach | 89% | 1463.02 | 321 / 359 | 92% | 5.14 | 264 / 286 |
bladder | 100% | 2692.95 | 21 / 21 | 80% | 4.85 | 402 / 504 |
breast | 100% | 3022.61 | 459 / 459 | 70% | 3.52 | 781 / 1118 |
ovary | 100% | 4840.97 | 180 / 180 | 66% | 3.31 | 285 / 430 |
skin | 90% | 2899.04 | 1626 / 1809 | 63% | 2.72 | 299 / 472 |
prostate | 100% | 3172.91 | 244 / 245 | 35% | 1.12 | 178 / 502 |
adipose | 100% | 3561.95 | 1204 / 1204 | 0% | 0 | 0 / 0 |
spleen | 100% | 4336.56 | 241 / 241 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 2609.78 | 1330 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 3728.94 | 799 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 92% | 3564.66 | 855 / 929 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 91% | 9.40 | 41 / 45 |
heart | 85% | 1376.98 | 730 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 73% | 2.62 | 58 / 80 |
liver | 43% | 420.52 | 97 / 226 | 26% | 0.90 | 107 / 406 |
lymph node | 0% | 0 | 0 / 0 | 52% | 4.61 | 15 / 29 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0007265 | Biological process | Ras protein signal transduction |
GO_0000165 | Biological process | MAPK cascade |
GO_0019933 | Biological process | cAMP-mediated signaling |
GO_0043410 | Biological process | positive regulation of MAPK cascade |
GO_0043405 | Biological process | regulation of MAP kinase activity |
GO_0042127 | Biological process | regulation of cell population proliferation |
GO_0032587 | Cellular component | ruffle membrane |
GO_0016020 | Cellular component | membrane |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0032991 | Cellular component | protein-containing complex |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0106310 | Molecular function | protein serine kinase activity |
GO_0005078 | Molecular function | MAP-kinase scaffold activity |
GO_0071889 | Molecular function | 14-3-3 protein binding |
GO_0004674 | Molecular function | protein serine/threonine kinase activity |
GO_0004672 | Molecular function | protein kinase activity |
GO_0046872 | Molecular function | metal ion binding |
GO_0005524 | Molecular function | ATP binding |
GO_0005515 | Molecular function | protein binding |
Gene name | KSR1 |
Protein name | Kinase suppressor of Ras 1 (EC 2.7.11.1) Kinase suppressor of ras 1 |
Synonyms | KSR |
Description | FUNCTION: Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 . Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (By similarity). Its kinase activity is unsure (By similarity). Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (By similarity). . |
Accessions | Q8IVT5 ENST00000398988.7 [Q8IVT5-4] A0A2R8Y5H9 A8MY87 A0A0A0MQW1 ENST00000268763.10 A0A2R8Y4X0 ENST00000580430.1 ENST00000398982.6 ENST00000583370.5 J3QLI1 ENST00000582410.5 ENST00000644974.2 ENST00000577823.5 J3QQL4 J3QR75 J3QSG8 ENST00000644418.1 |