KSR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007265Biological processRas protein signal transduction
GO_0000165Biological processMAPK cascade
GO_0019933Biological processcAMP-mediated signaling
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0043405Biological processregulation of MAP kinase activity
GO_0042127Biological processregulation of cell population proliferation
GO_0032587Cellular componentruffle membrane
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0032991Cellular componentprotein-containing complex
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0106310Molecular functionprotein serine kinase activity
GO_0005078Molecular functionMAP-kinase scaffold activity
GO_0071889Molecular function14-3-3 protein binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0004672Molecular functionprotein kinase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKSR1
Protein nameKinase suppressor of Ras 1 (EC 2.7.11.1)
Kinase suppressor of ras 1
SynonymsKSR
DescriptionFUNCTION: Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 . Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (By similarity). Its kinase activity is unsure (By similarity). Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (By similarity). .

AccessionsQ8IVT5
ENST00000398988.7 [Q8IVT5-4]
A0A2R8Y5H9
A8MY87
A0A0A0MQW1
ENST00000268763.10
A0A2R8Y4X0
ENST00000580430.1
ENST00000398982.6
ENST00000583370.5
J3QLI1
ENST00000582410.5
ENST00000644974.2
ENST00000577823.5
J3QQL4
J3QR75
J3QSG8
ENST00000644418.1