MAPK15 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MAPK15 at tissue level.

III. Associated gene sets

GO_1904355Biological processpositive regulation of telomere capping
GO_0000165Biological processMAPK cascade
GO_0003400Biological processregulation of COPII vesicle coating
GO_0007029Biological processendoplasmic reticulum organization
GO_0090494Biological processdopamine uptake
GO_0006974Biological processDNA damage response
GO_1905188Biological processpositive regulation of metaphase/anaphase transition of meiosis I
GO_1905832Biological processpositive regulation of spindle assembly
GO_1902017Biological processregulation of cilium assembly
GO_1904491Biological processprotein localization to ciliary transition zone
GO_0035556Biological processintracellular signal transduction
GO_0010506Biological processregulation of autophagy
GO_0051973Biological processpositive regulation of telomerase activity
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0030336Biological processnegative regulation of cell migration
GO_0046777Biological processprotein autophosphorylation
GO_0032212Biological processpositive regulation of telomere maintenance via telomerase
GO_0005576Cellular componentextracellular region
GO_0031410Cellular componentcytoplasmic vesicle
GO_0005794Cellular componentGolgi apparatus
GO_0005814Cellular componentcentriole
GO_0005930Cellular componentaxoneme
GO_0005911Cellular componentcell-cell junction
GO_0005776Cellular componentautophagosome
GO_0005737Cellular componentcytoplasm
GO_0005923Cellular componentbicellular tight junction
GO_0072687Cellular componentmeiotic spindle
GO_0036064Cellular componentciliary basal body
GO_0005634Cellular componentnucleus
GO_0004707Molecular functionMAP kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0003682Molecular functionchromatin binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0004672Molecular functionprotein kinase activity
GO_0005524Molecular functionATP binding
GO_0016301Molecular functionkinase activity
GO_0005515Molecular functionprotein binding
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene nameMAPK15
Protein nameMitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8)
Mitogen-activated protein kinase 15 (EC 2.7.11.24)
SynonymsERK7
ERK8
DescriptionFUNCTION: Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner . Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation . Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling . Prevents the relocation of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins . Upon amino-acid starvation, mediates transitional endoplasmic reticulum site disassembly and inhibition of secretion . Binds to chromatin leading to MAPK15 activation and interaction with PCNA, that which protects genomic integrity by inhibiting MDM2-mediated degradation of PCNA . Regulates DA transporter (DAT) activity and protein expression via activation of RhoA . In response to H(2)O(2) treatment phosphorylates ELAVL1, thus preventing it from binding to the PDCD4 3'UTR and rendering the PDCD4 mRNA accessible to miR-21 and leading to its degradation and loss of protein expression . Also functions in a kinase activity-independent manner as a negative regulator of growth (By similarity). Phosphorylates in vitro FOS and MBP . During oocyte maturation, plays a key role in the microtubule organization and meiotic cell cycle progression in oocytes, fertilized eggs, and early embryos (By similarity). Interacts with ESRRA promoting its re-localization from the nucleus to the cytoplasm and then prevents its transcriptional activity . .

AccessionsENST00000615253.4 [Q8TD08-1]
Q8TD08
A0A1C7CYZ1
ENST00000395107.8 [Q8TD08-3]
ENST00000395108.2 [Q8TD08-2]
ENST00000620781.2
ENST00000338033.9 [Q8TD08-1]