MAP3K8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031295Biological processT cell costimulation
GO_0006468Biological processprotein phosphorylation
GO_0000165Biological processMAPK cascade
GO_0005829Cellular componentcytosol
GO_0004709Molecular functionMAP kinase kinase kinase activity
GO_0005524Molecular functionATP binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0005515Molecular functionprotein binding
GO_0000287Molecular functionmagnesium ion binding

IV. Literature review

[source]
Gene nameMAP3K8
Protein nameMitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25)
Mitogen-activated protein kinase kinase kinase 8
Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (Cancer Osaka thyroid oncogene) (Proto-oncogene c-Cot) (Serine/threonine-protein kinase cot) (Tumor progression locus 2) (TPL-2)
MAP3K8 protein
SynonymsCOT
ESTF
DescriptionFUNCTION: Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the pro-inflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle. Isoform 1 shows some transforming activity, although it is much weaker than that of the activated oncogenic variant. .

AccessionsENST00000263056.6 [P41279-1]
ENST00000413724.5
ENST00000542547.5 [P41279-1]
ENST00000375321.1 [P41279-1]
ENST00000415139.5
Q5T857
ENST00000375322.2
Q5T854
Q5T853
P41279
Q6FG25