Name | Number of supported studies | Average coverage | |
---|---|---|---|
oligodendrocyte | 11 studies | 28% ± 10% | |
astrocyte | 11 studies | 26% ± 12% | |
glutamatergic neuron | 10 studies | 42% ± 22% | |
endothelial cell | 9 studies | 31% ± 15% | |
oligodendrocyte precursor cell | 9 studies | 25% ± 11% | |
GABAergic neuron | 8 studies | 41% ± 22% | |
microglial cell | 7 studies | 24% ± 8% | |
macrophage | 6 studies | 27% ± 7% | |
retinal ganglion cell | 6 studies | 42% ± 20% | |
neuron | 5 studies | 34% ± 14% | |
interneuron | 5 studies | 39% ± 21% | |
retina horizontal cell | 5 studies | 26% ± 6% | |
B cell | 5 studies | 20% ± 5% | |
ciliated cell | 4 studies | 17% ± 1% | |
granule cell | 4 studies | 33% ± 7% | |
memory B cell | 4 studies | 19% ± 3% | |
fibroblast | 4 studies | 21% ± 5% | |
GABAergic interneuron | 3 studies | 27% ± 7% | |
epithelial cell | 3 studies | 26% ± 10% | |
basal cell | 3 studies | 25% ± 10% | |
amacrine cell | 3 studies | 19% ± 2% | |
endothelial cell of lymphatic vessel | 3 studies | 21% ± 6% | |
monocyte | 3 studies | 19% ± 4% | |
cardiac muscle cell | 3 studies | 16% ± 1% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 15 studies | 33% ± 16% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 6327.69 | 1441 / 1445 | 100% | 23.96 | 183 / 183 |
brain | 100% | 22922.86 | 2641 / 2642 | 99% | 61.61 | 701 / 705 |
adrenal gland | 100% | 8880.51 | 258 / 258 | 99% | 45.35 | 228 / 230 |
uterus | 100% | 10106.82 | 170 / 170 | 98% | 20.69 | 450 / 459 |
pancreas | 100% | 6650.81 | 328 / 328 | 97% | 24.92 | 172 / 178 |
bladder | 100% | 10507.00 | 21 / 21 | 96% | 20.88 | 486 / 504 |
thymus | 100% | 12572.06 | 653 / 653 | 96% | 19.16 | 583 / 605 |
prostate | 100% | 13788.74 | 245 / 245 | 95% | 16.16 | 477 / 502 |
intestine | 100% | 8939.82 | 966 / 966 | 94% | 17.13 | 496 / 527 |
stomach | 99% | 6159.07 | 357 / 359 | 94% | 15.68 | 268 / 286 |
breast | 100% | 8506.64 | 459 / 459 | 93% | 17.10 | 1041 / 1118 |
lung | 100% | 9714.65 | 576 / 578 | 93% | 19.36 | 1074 / 1155 |
ovary | 100% | 13288.75 | 180 / 180 | 92% | 15.77 | 397 / 430 |
kidney | 100% | 9097.46 | 89 / 89 | 92% | 22.31 | 826 / 901 |
skin | 100% | 9443.55 | 1808 / 1809 | 91% | 17.72 | 431 / 472 |
liver | 99% | 4729.19 | 224 / 226 | 61% | 7.80 | 247 / 406 |
spleen | 100% | 14640.24 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 12.81 | 1 / 1 |
adipose | 100% | 7639.13 | 1202 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 99% | 6588.69 | 1324 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 98% | 7984.89 | 907 / 929 | 0% | 0 | 0 / 0 |
heart | 97% | 7365.83 | 839 / 861 | 0% | 0 | 0 / 0 |
muscle | 92% | 3743.70 | 740 / 803 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 90% | 19.72 | 26 / 29 |
tonsil | 0% | 0 | 0 / 0 | 89% | 13.22 | 40 / 45 |
eye | 0% | 0 | 0 / 0 | 63% | 8.69 | 50 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0046328 | Biological process | regulation of JNK cascade |
GO_0031103 | Biological process | axon regeneration |
GO_0061564 | Biological process | axon development |
GO_0000165 | Biological process | MAPK cascade |
GO_0046330 | Biological process | positive regulation of JNK cascade |
GO_0016192 | Biological process | vesicle-mediated transport |
GO_0043066 | Biological process | negative regulation of apoptotic process |
GO_0050821 | Biological process | protein stabilization |
GO_0099641 | Biological process | anterograde axonal protein transport |
GO_0031410 | Cellular component | cytoplasmic vesicle |
GO_0048471 | Cellular component | perinuclear region of cytoplasm |
GO_0030425 | Cellular component | dendrite |
GO_0000139 | Cellular component | Golgi membrane |
GO_0030426 | Cellular component | growth cone |
GO_0005737 | Cellular component | cytoplasm |
GO_0044297 | Cellular component | cell body |
GO_0030424 | Cellular component | axon |
GO_1904115 | Cellular component | axon cytoplasm |
GO_0008432 | Molecular function | JUN kinase binding |
GO_0005078 | Molecular function | MAP-kinase scaffold activity |
GO_0030159 | Molecular function | signaling receptor complex adaptor activity |
GO_0005515 | Molecular function | protein binding |
GO_0019894 | Molecular function | kinesin binding |
Gene name | MAPK8IP3 |
Protein name | Mitogen-activated protein kinase 8 interacting protein 3 C-Jun-amino-terminal kinase-interacting protein 3 (JIP-3) (JNK-interacting protein 3) (JNK MAP kinase scaffold protein 3) (Mitogen-activated protein kinase 8-interacting protein 3) MAPK8IP3 protein C-Jun-amino-terminal kinase-interacting protein 3 |
Synonyms | KIAA1066 JIP3 |
Description | FUNCTION: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module . May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration. Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development (By similarity). Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation . . |
Accessions | ENST00000567849.1 A0A087WYG2 E9PFH7 A0A8I5KWZ2 G1UI24 ENST00000610761.2 B7ZMF3 A0A669KB35 ENST00000685565.1 H3BN91 Q9UPT6 ENST00000250894.8 [Q9UPT6-1] ENST00000673691.1 ENST00000356010.9 |