MAPK8IP3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046328Biological processregulation of JNK cascade
GO_0031103Biological processaxon regeneration
GO_0061564Biological processaxon development
GO_0000165Biological processMAPK cascade
GO_0046330Biological processpositive regulation of JNK cascade
GO_0016192Biological processvesicle-mediated transport
GO_0043066Biological processnegative regulation of apoptotic process
GO_0050821Biological processprotein stabilization
GO_0099641Biological processanterograde axonal protein transport
GO_0031410Cellular componentcytoplasmic vesicle
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0030425Cellular componentdendrite
GO_0000139Cellular componentGolgi membrane
GO_0030426Cellular componentgrowth cone
GO_0005737Cellular componentcytoplasm
GO_0044297Cellular componentcell body
GO_0030424Cellular componentaxon
GO_1904115Cellular componentaxon cytoplasm
GO_0008432Molecular functionJUN kinase binding
GO_0005078Molecular functionMAP-kinase scaffold activity
GO_0030159Molecular functionsignaling receptor complex adaptor activity
GO_0005515Molecular functionprotein binding
GO_0019894Molecular functionkinesin binding

IV. Literature review

[source]
Gene nameMAPK8IP3
Protein nameMitogen-activated protein kinase 8 interacting protein 3
C-Jun-amino-terminal kinase-interacting protein 3 (JIP-3) (JNK-interacting protein 3) (JNK MAP kinase scaffold protein 3) (Mitogen-activated protein kinase 8-interacting protein 3)
MAPK8IP3 protein
C-Jun-amino-terminal kinase-interacting protein 3
SynonymsKIAA1066
JIP3
DescriptionFUNCTION: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module . May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration. Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development (By similarity). Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation . .

AccessionsENST00000567849.1
A0A087WYG2
E9PFH7
A0A8I5KWZ2
G1UI24
ENST00000610761.2
B7ZMF3
A0A669KB35
ENST00000685565.1
H3BN91
Q9UPT6
ENST00000250894.8 [Q9UPT6-1]
ENST00000673691.1
ENST00000356010.9