MAP3K14 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MAP3K14 at tissue level.

III. Associated gene sets

GO_0007249Biological processcanonical NF-kappaB signal transduction
GO_0006955Biological processimmune response
GO_0051607Biological processdefense response to virus
GO_0038061Biological processnon-canonical NF-kappaB signal transduction
GO_0071260Biological processcellular response to mechanical stimulus
GO_0000165Biological processMAPK cascade
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0001650Cellular componentfibrillar center
GO_0004709Molecular functionMAP kinase kinase kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0005515Molecular functionprotein binding
GO_0004672Molecular functionprotein kinase activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameMAP3K14
Protein nameMitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa-beta-inducing kinase) (HsNIK) (Serine/threonine-protein kinase NIK)
Mitogen-activated protein kinase kinase kinase 14
SynonymsNIK
DescriptionFUNCTION: Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Phosphorylates CHUK/IKKA, thereby promoting proteolytic processing of NFKB2/P100, which leads to NF-kappa-B activation via the non-canonical pathway . Has an essential role in the non-canonical NF-kappa-B signaling that regulates genes encoding molecules involved in B-cell survival, lymphoid organogenesis, and immune response . Could act in a receptor-selective manner. .

AccessionsENST00000376926.8
A0A087WXF1
ENST00000680632.1
ENST00000617331.3
ENST00000344686.8
ENST00000617331
Q99558
A0A7P0Z419