MINK1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007254Biological processJNK cascade
GO_0000165Biological processMAPK cascade
GO_0022407Biological processregulation of cell-cell adhesion
GO_0048813Biological processdendrite morphogenesis
GO_0046330Biological processpositive regulation of JNK cascade
GO_0001952Biological processregulation of cell-matrix adhesion
GO_1900745Biological processpositive regulation of p38MAPK cascade
GO_0048812Biological processneuron projection morphogenesis
GO_0030033Biological processmicrovillus assembly
GO_0030036Biological processactin cytoskeleton organization
GO_0007268Biological processchemical synaptic transmission
GO_0030334Biological processregulation of cell migration
GO_2000311Biological processregulation of AMPA receptor activity
GO_0007420Biological processbrain development
GO_0006468Biological processprotein phosphorylation
GO_0043408Biological processregulation of MAPK cascade
GO_0046777Biological processprotein autophosphorylation
GO_0070062Cellular componentextracellular exosome
GO_0005794Cellular componentGolgi apparatus
GO_0030425Cellular componentdendrite
GO_0005829Cellular componentcytosol
GO_0014069Cellular componentpostsynaptic density
GO_0005737Cellular componentcytoplasm
GO_0030424Cellular componentaxon
GO_0106310Molecular functionprotein serine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0004672Molecular functionprotein kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMINK1
Protein namenon-specific serine/threonine protein kinase (EC 2.7.11.1)
Misshapen like kinase 1
Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6)
SynonymsMAP4K6
ZC3
MINK
YSK2
B55
DescriptionFUNCTION: Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.

AccessionsQ8N4C8
I3L2I2
I3L1U1
ENST00000574453.5
ENST00000664602.1
ENST00000577021.1
ENST00000347992.11 [Q8N4C8-3]
ENST00000355280.11 [Q8N4C8-1]
ENST00000453408.7 [Q8N4C8-4]
A0A590UJE1
I3L4T2
I3L203
ENST00000571207.5
ENST00000576037.1