Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 10 studies | 24% ± 11% | |
astrocyte | 9 studies | 33% ± 13% | |
oligodendrocyte | 8 studies | 26% ± 7% | |
macrophage | 7 studies | 25% ± 8% | |
glutamatergic neuron | 5 studies | 38% ± 19% | |
microglial cell | 5 studies | 26% ± 10% | |
epithelial cell | 5 studies | 27% ± 12% | |
basal cell | 5 studies | 33% ± 15% | |
interneuron | 4 studies | 29% ± 16% | |
alveolar macrophage | 4 studies | 26% ± 5% | |
neuron | 3 studies | 27% ± 13% | |
endothelial cell of lymphatic vessel | 3 studies | 37% ± 26% | |
GABAergic neuron | 3 studies | 41% ± 11% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 7 studies | 33% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
stomach | 100% | 6430.92 | 359 / 359 | 100% | 59.62 | 286 / 286 |
esophagus | 100% | 13092.42 | 1444 / 1445 | 100% | 82.08 | 183 / 183 |
intestine | 100% | 10110.36 | 966 / 966 | 100% | 60.08 | 526 / 527 |
brain | 100% | 12079.26 | 2631 / 2642 | 100% | 74.71 | 703 / 705 |
skin | 100% | 18613.06 | 1807 / 1809 | 99% | 42.44 | 469 / 472 |
lung | 100% | 12637.25 | 578 / 578 | 99% | 47.18 | 1143 / 1155 |
ovary | 100% | 17323.07 | 180 / 180 | 99% | 37.85 | 425 / 430 |
bladder | 100% | 7988.86 | 21 / 21 | 99% | 47.76 | 497 / 504 |
uterus | 100% | 9018.25 | 170 / 170 | 98% | 57.88 | 450 / 459 |
pancreas | 100% | 5128.92 | 327 / 328 | 98% | 45.98 | 175 / 178 |
breast | 100% | 9285.35 | 459 / 459 | 98% | 37.47 | 1095 / 1118 |
thymus | 100% | 8510.38 | 652 / 653 | 98% | 37.74 | 591 / 605 |
prostate | 100% | 11474.58 | 245 / 245 | 97% | 36.85 | 487 / 502 |
kidney | 100% | 7686.53 | 89 / 89 | 97% | 39.50 | 872 / 901 |
adrenal gland | 100% | 8389.10 | 258 / 258 | 89% | 26.76 | 205 / 230 |
liver | 91% | 3314.84 | 205 / 226 | 74% | 17.55 | 300 / 406 |
adipose | 100% | 7471.91 | 1204 / 1204 | 0% | 0 | 0 / 0 |
spleen | 100% | 9709.34 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 77.92 | 45 / 45 |
blood vessel | 99% | 6149.65 | 1328 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 99% | 36.73 | 79 / 80 |
heart | 93% | 4027.84 | 803 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 93% | 32.69 | 27 / 29 |
peripheral blood | 90% | 4979.76 | 837 / 929 | 0% | 0 | 0 / 0 |
muscle | 67% | 2020.47 | 537 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0007254 | Biological process | JNK cascade |
GO_0000165 | Biological process | MAPK cascade |
GO_0022407 | Biological process | regulation of cell-cell adhesion |
GO_0048813 | Biological process | dendrite morphogenesis |
GO_0046330 | Biological process | positive regulation of JNK cascade |
GO_0001952 | Biological process | regulation of cell-matrix adhesion |
GO_1900745 | Biological process | positive regulation of p38MAPK cascade |
GO_0048812 | Biological process | neuron projection morphogenesis |
GO_0030033 | Biological process | microvillus assembly |
GO_0030036 | Biological process | actin cytoskeleton organization |
GO_0007268 | Biological process | chemical synaptic transmission |
GO_0030334 | Biological process | regulation of cell migration |
GO_2000311 | Biological process | regulation of AMPA receptor activity |
GO_0007420 | Biological process | brain development |
GO_0006468 | Biological process | protein phosphorylation |
GO_0043408 | Biological process | regulation of MAPK cascade |
GO_0046777 | Biological process | protein autophosphorylation |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0030425 | Cellular component | dendrite |
GO_0005829 | Cellular component | cytosol |
GO_0014069 | Cellular component | postsynaptic density |
GO_0005737 | Cellular component | cytoplasm |
GO_0030424 | Cellular component | axon |
GO_0106310 | Molecular function | protein serine kinase activity |
GO_0004674 | Molecular function | protein serine/threonine kinase activity |
GO_0004672 | Molecular function | protein kinase activity |
GO_0005524 | Molecular function | ATP binding |
GO_0005515 | Molecular function | protein binding |
Gene name | MINK1 |
Protein name | non-specific serine/threonine protein kinase (EC 2.7.11.1) Misshapen like kinase 1 Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6) |
Synonyms | MAP4K6 ZC3 MINK YSK2 B55 |
Description | FUNCTION: Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.; FUNCTION: Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. |
Accessions | Q8N4C8 I3L2I2 I3L1U1 ENST00000574453.5 ENST00000664602.1 ENST00000577021.1 ENST00000347992.11 [Q8N4C8-3] ENST00000355280.11 [Q8N4C8-1] ENST00000453408.7 [Q8N4C8-4] A0A590UJE1 I3L4T2 I3L203 ENST00000571207.5 ENST00000576037.1 |