MAP2K4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007254Biological processJNK cascade
GO_0051770Biological processpositive regulation of nitric-oxide synthase biosynthetic process
GO_0071260Biological processcellular response to mechanical stimulus
GO_0000165Biological processMAPK cascade
GO_0061049Biological processcell growth involved in cardiac muscle cell development
GO_0034390Biological processsmooth muscle cell apoptotic process
GO_0046330Biological processpositive regulation of JNK cascade
GO_0007165Biological processsignal transduction
GO_0038095Biological processFc-epsilon receptor signaling pathway
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0072709Biological processcellular response to sorbitol
GO_0043525Biological processpositive regulation of neuron apoptotic process
GO_0045740Biological processpositive regulation of DNA replication
GO_2000672Biological processnegative regulation of motor neuron apoptotic process
GO_0090398Biological processcellular senescence
GO_0036481Biological processintrinsic apoptotic signaling pathway in response to hydrogen peroxide
GO_0009611Biological processresponse to wounding
GO_0043204Cellular componentperikaryon
GO_0005829Cellular componentcytosol
GO_0030424Cellular componentaxon
GO_0032839Cellular componentdendrite cytoplasm
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0060090Molecular functionmolecular adaptor activity
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0008545Molecular functionJUN kinase kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0004672Molecular functionprotein kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMAP2K4
Protein nameMitogen-activated protein kinase kinase 4
Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1) (Stress-activated protein kinase kinase 1) (SAPK kinase 1) (SAPKK-1) (SAPKK1) (c-Jun N-terminal kinase kinase 1) (JNKK)
SynonymsMKK4
SKK1
SERK1
JNKK1
PRKMK4
MEK4
SEK1
DescriptionFUNCTION: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to pro-inflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14. .

AccessionsENST00000415385.7 [P45985-2]
R4GN37
ENST00000353533.10 [P45985-1]
ENST00000538465.7
ENST00000602537.5
ENST00000602305.5
K7EP58
J3QLE2
ENST00000602811.5
ENST00000602686.5
R4GN68
ENST00000582183.5
P45985
ENST00000602375.5