Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 18 studies | 31% ± 15% | |
oligodendrocyte | 13 studies | 38% ± 15% | |
glutamatergic neuron | 12 studies | 55% ± 26% | |
astrocyte | 12 studies | 35% ± 15% | |
oligodendrocyte precursor cell | 12 studies | 41% ± 17% | |
GABAergic neuron | 11 studies | 48% ± 25% | |
microglial cell | 10 studies | 29% ± 9% | |
fibroblast | 9 studies | 27% ± 11% | |
neuron | 7 studies | 43% ± 17% | |
interneuron | 6 studies | 56% ± 25% | |
macrophage | 6 studies | 34% ± 8% | |
adipocyte | 6 studies | 24% ± 4% | |
smooth muscle cell | 6 studies | 23% ± 5% | |
epithelial cell | 5 studies | 40% ± 24% | |
ciliated cell | 5 studies | 25% ± 9% | |
endothelial cell of lymphatic vessel | 5 studies | 28% ± 6% | |
club cell | 5 studies | 29% ± 10% | |
pericyte | 5 studies | 26% ± 8% | |
type I pneumocyte | 5 studies | 28% ± 10% | |
type II pneumocyte | 5 studies | 27% ± 7% | |
granule cell | 4 studies | 38% ± 12% | |
retinal ganglion cell | 4 studies | 27% ± 16% | |
cardiac muscle cell | 4 studies | 22% ± 3% | |
amacrine cell | 4 studies | 27% ± 10% | |
retina horizontal cell | 4 studies | 33% ± 14% | |
retinal rod cell | 4 studies | 22% ± 3% | |
monocyte | 4 studies | 21% ± 3% | |
GABAergic interneuron | 3 studies | 46% ± 4% | |
GABAergic amacrine cell | 3 studies | 32% ± 11% | |
glycinergic amacrine cell | 3 studies | 29% ± 2% | |
hepatocyte | 3 studies | 47% ± 26% | |
abnormal cell | 3 studies | 27% ± 13% | |
ependymal cell | 3 studies | 34% ± 18% | |
T cell | 3 studies | 20% ± 2% | |
respiratory goblet cell | 3 studies | 29% ± 12% | |
lymphocyte | 3 studies | 25% ± 9% | |
basal cell | 3 studies | 45% ± 29% | |
dendritic cell | 3 studies | 18% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 2213.01 | 245 / 245 | 100% | 27.12 | 502 / 502 |
brain | 100% | 4291.86 | 2638 / 2642 | 100% | 28.48 | 705 / 705 |
thymus | 100% | 2214.66 | 653 / 653 | 100% | 26.55 | 603 / 605 |
lung | 100% | 1805.62 | 577 / 578 | 100% | 19.42 | 1153 / 1155 |
esophagus | 100% | 2323.41 | 1445 / 1445 | 99% | 24.34 | 182 / 183 |
breast | 100% | 1925.38 | 459 / 459 | 99% | 29.34 | 1109 / 1118 |
bladder | 100% | 1929.05 | 21 / 21 | 99% | 16.89 | 499 / 504 |
uterus | 100% | 1990.79 | 170 / 170 | 99% | 17.99 | 454 / 459 |
kidney | 100% | 1629.81 | 89 / 89 | 99% | 20.43 | 891 / 901 |
adrenal gland | 100% | 2303.40 | 258 / 258 | 99% | 16.57 | 227 / 230 |
intestine | 100% | 1815.59 | 966 / 966 | 98% | 14.95 | 518 / 527 |
stomach | 100% | 1448.15 | 359 / 359 | 98% | 15.82 | 280 / 286 |
ovary | 100% | 1855.63 | 180 / 180 | 98% | 13.27 | 420 / 430 |
pancreas | 98% | 988.44 | 323 / 328 | 98% | 14.55 | 175 / 178 |
skin | 100% | 2565.85 | 1808 / 1809 | 97% | 16.75 | 456 / 472 |
liver | 100% | 1279.27 | 226 / 226 | 93% | 9.89 | 377 / 406 |
adipose | 100% | 1782.18 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 16.27 | 29 / 29 |
muscle | 100% | 2409.64 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 1745.32 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 19.20 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 7.25 | 1 / 1 |
blood vessel | 100% | 1920.66 | 1334 / 1335 | 0% | 0 | 0 / 0 |
heart | 95% | 1382.85 | 819 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 93% | 1743.15 | 861 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 86% | 9.64 | 69 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0007254 | Biological process | JNK cascade |
GO_0051770 | Biological process | positive regulation of nitric-oxide synthase biosynthetic process |
GO_0071260 | Biological process | cellular response to mechanical stimulus |
GO_0000165 | Biological process | MAPK cascade |
GO_0061049 | Biological process | cell growth involved in cardiac muscle cell development |
GO_0034390 | Biological process | smooth muscle cell apoptotic process |
GO_0046330 | Biological process | positive regulation of JNK cascade |
GO_0007165 | Biological process | signal transduction |
GO_0038095 | Biological process | Fc-epsilon receptor signaling pathway |
GO_0001934 | Biological process | positive regulation of protein phosphorylation |
GO_0072709 | Biological process | cellular response to sorbitol |
GO_0043525 | Biological process | positive regulation of neuron apoptotic process |
GO_0045740 | Biological process | positive regulation of DNA replication |
GO_2000672 | Biological process | negative regulation of motor neuron apoptotic process |
GO_0090398 | Biological process | cellular senescence |
GO_0036481 | Biological process | intrinsic apoptotic signaling pathway in response to hydrogen peroxide |
GO_0009611 | Biological process | response to wounding |
GO_0043204 | Cellular component | perikaryon |
GO_0005829 | Cellular component | cytosol |
GO_0030424 | Cellular component | axon |
GO_0032839 | Cellular component | dendrite cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0106310 | Molecular function | protein serine kinase activity |
GO_0060090 | Molecular function | molecular adaptor activity |
GO_0004713 | Molecular function | protein tyrosine kinase activity |
GO_0008545 | Molecular function | JUN kinase kinase activity |
GO_0004674 | Molecular function | protein serine/threonine kinase activity |
GO_0004672 | Molecular function | protein kinase activity |
GO_0005524 | Molecular function | ATP binding |
GO_0005515 | Molecular function | protein binding |
Gene name | MAP2K4 |
Protein name | Mitogen-activated protein kinase kinase 4 Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1) (Stress-activated protein kinase kinase 1) (SAPK kinase 1) (SAPKK-1) (SAPKK1) (c-Jun N-terminal kinase kinase 1) (JNKK) |
Synonyms | MKK4 SKK1 SERK1 JNKK1 PRKMK4 MEK4 SEK1 |
Description | FUNCTION: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to pro-inflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14. . |
Accessions | ENST00000415385.7 [P45985-2] R4GN37 ENST00000353533.10 [P45985-1] ENST00000538465.7 ENST00000602537.5 ENST00000602305.5 K7EP58 J3QLE2 ENST00000602811.5 ENST00000602686.5 R4GN68 ENST00000582183.5 P45985 ENST00000602375.5 |