BRAF | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	24 studies	43% ± 14%	Explore
astrocyte	19 studies	43% ± 18%	Explore
oligodendrocyte	16 studies	37% ± 14%	Explore
microglial cell	14 studies	43% ± 10%	Explore
fibroblast	14 studies	36% ± 14%	Explore
glutamatergic neuron	13 studies	58% ± 25%	Explore
oligodendrocyte precursor cell	13 studies	48% ± 17%	Explore
mast cell	12 studies	29% ± 10%	Explore
GABAergic neuron	11 studies	57% ± 23%	Explore
B cell	11 studies	31% ± 11%	Explore
macrophage	11 studies	38% ± 15%	Explore
smooth muscle cell	11 studies	31% ± 11%	Explore
pericyte	10 studies	39% ± 13%	Explore
adipocyte	9 studies	42% ± 10%	Explore
epithelial cell	8 studies	39% ± 16%	Explore
endothelial cell of lymphatic vessel	8 studies	44% ± 16%	Explore
CD4-positive, alpha-beta T cell	7 studies	23% ± 5%	Explore
T cell	7 studies	30% ± 12%	Explore
naive B cell	6 studies	20% ± 4%	Explore
neuron	6 studies	53% ± 18%	Explore
interneuron	6 studies	68% ± 18%	Explore
myeloid cell	6 studies	30% ± 4%	Explore
natural killer cell	6 studies	29% ± 7%	Explore
CD8-positive, alpha-beta T cell	5 studies	23% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	27% ± 6%	Explore
mature NK T cell	5 studies	21% ± 9%	Explore
cardiac muscle cell	5 studies	48% ± 12%	Explore
dendritic cell	5 studies	34% ± 8%	Explore
ciliated cell	5 studies	36% ± 13%	Explore
retina horizontal cell	5 studies	41% ± 16%	Explore
monocyte	5 studies	40% ± 10%	Explore
club cell	5 studies	41% ± 15%	Explore
type I pneumocyte	5 studies	48% ± 9%	Explore
type II pneumocyte	5 studies	57% ± 10%	Explore
classical monocyte	4 studies	21% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	4 studies	24% ± 4%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	23% ± 4%	Explore
granule cell	4 studies	52% ± 8%	Explore
mesothelial cell	4 studies	35% ± 8%	Explore
vein endothelial cell	4 studies	34% ± 21%	Explore
Mueller cell	4 studies	41% ± 12%	Explore
amacrine cell	4 studies	49% ± 12%	Explore
retinal cone cell	4 studies	54% ± 13%	Explore
retinal ganglion cell	4 studies	38% ± 17%	Explore
retinal rod cell	4 studies	49% ± 7%	Explore
goblet cell	4 studies	39% ± 28%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	26% ± 4%	Explore
non-classical monocyte	3 studies	24% ± 6%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	43% ± 3%	Explore
GABAergic interneuron	3 studies	55% ± 3%	Explore
progenitor cell	3 studies	36% ± 5%	Explore
plasma cell	3 studies	34% ± 5%	Explore
endothelial cell of artery	3 studies	20% ± 4%	Explore
GABAergic amacrine cell	3 studies	47% ± 7%	Explore
OFF-bipolar cell	3 studies	44% ± 19%	Explore
ON-bipolar cell	3 studies	41% ± 18%	Explore
glycinergic amacrine cell	3 studies	46% ± 5%	Explore
rod bipolar cell	3 studies	41% ± 18%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	19% ± 1%	Explore
gamma-delta T cell	3 studies	22% ± 5%	Explore
regulatory T cell	3 studies	18% ± 1%	Explore
endothelial cell of vascular tree	3 studies	47% ± 17%	Explore
hepatocyte	3 studies	58% ± 19%	Explore
retinal pigment epithelial cell	3 studies	43% ± 26%	Explore
abnormal cell	3 studies	34% ± 23%	Explore
ependymal cell	3 studies	51% ± 14%	Explore
leukocyte	3 studies	33% ± 8%	Explore
myofibroblast cell	3 studies	37% ± 16%	Explore
alveolar macrophage	3 studies	38% ± 9%	Explore
capillary endothelial cell	3 studies	36% ± 8%	Explore
respiratory goblet cell	3 studies	34% ± 14%	Explore
lymphocyte	3 studies	40% ± 13%	Explore
muscle cell	3 studies	37% ± 24%	Explore
basal cell	3 studies	44% ± 19%	Explore
transit amplifying cell	3 studies	37% ± 29%	Explore
mucus secreting cell	3 studies	32% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	16 studies	53% ± 19%	Explore
lung	6 studies	35% ± 12%	Explore
eye	5 studies	51% ± 11%	Explore
peripheral blood	4 studies	26% ± 6%	Explore
heart	4 studies	40% ± 6%	Explore
adipose	3 studies	39% ± 8%	Explore
kidney	3 studies	37% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2223.08	1445 / 1445	100%	5.78	183 / 183
ovary	100%	2932.82	180 / 180	100%	4.30	430 / 430
prostate	100%	2739.27	245 / 245	100%	7.03	502 / 502
lung	100%	3056.14	578 / 578	100%	5.24	1152 / 1155
breast	100%	2860.33	459 / 459	100%	6.31	1114 / 1118
pancreas	100%	1369.44	328 / 328	99%	4.87	177 / 178
uterus	100%	2954.01	170 / 170	99%	4.07	456 / 459
thymus	100%	3345.64	653 / 653	99%	6.31	601 / 605
brain	100%	2518.21	2629 / 2642	100%	5.25	703 / 705
bladder	100%	2941.05	21 / 21	99%	4.79	500 / 504
kidney	100%	2042.89	89 / 89	99%	5.33	892 / 901
intestine	100%	2357.53	966 / 966	98%	3.49	519 / 527
stomach	100%	1859.46	359 / 359	98%	4.25	280 / 286
skin	100%	2775.80	1809 / 1809	97%	5.09	456 / 472
adrenal gland	100%	1588.87	258 / 258	96%	4.40	221 / 230
liver	100%	1042.33	226 / 226	90%	2.27	364 / 406
adipose	100%	2557.06	1204 / 1204	0%	0	0 / 0
blood vessel	100%	2622.21	1335 / 1335	0%	0	0 / 0
spleen	100%	2227.53	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	3.55	45 / 45
ureter	0%	0	0 / 0	100%	3.45	1 / 1
muscle	100%	1329.60	799 / 803	0%	0	0 / 0
peripheral blood	98%	2004.38	911 / 929	0%	0	0 / 0
heart	98%	1379.81	843 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	3.47	28 / 29
eye	0%	0	0 / 0	88%	2.34	70 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_2000352	Biological process	negative regulation of endothelial cell apoptotic process
GO_2000301	Biological process	negative regulation of synaptic vesicle exocytosis
GO_0071466	Biological process	cellular response to xenobiotic stimulus
GO_0045580	Biological process	regulation of T cell differentiation
GO_0010828	Biological process	positive regulation of glucose transmembrane transport
GO_0043434	Biological process	response to peptide hormone
GO_0050772	Biological process	positive regulation of axonogenesis
GO_0000165	Biological process	MAPK cascade
GO_0051496	Biological process	positive regulation of stress fiber assembly
GO_0009887	Biological process	animal organ morphogenesis
GO_0033138	Biological process	positive regulation of peptidyl-serine phosphorylation
GO_0010628	Biological process	positive regulation of gene expression
GO_0030878	Biological process	thyroid gland development
GO_0016079	Biological process	synaptic vesicle exocytosis
GO_0060291	Biological process	long-term synaptic potentiation
GO_0050852	Biological process	T cell receptor signaling pathway
GO_0010764	Biological process	negative regulation of fibroblast migration
GO_0008542	Biological process	visual learning
GO_0071277	Biological process	cellular response to calcium ion
GO_0033077	Biological process	T cell differentiation in thymus
GO_0072577	Biological process	endothelial cell apoptotic process
GO_0051591	Biological process	response to cAMP
GO_0070371	Biological process	ERK1 and ERK2 cascade
GO_0090150	Biological process	establishment of protein localization to membrane
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0034446	Biological process	substrate adhesion-dependent cell spreading
GO_0060324	Biological process	face development
GO_1990090	Biological process	cellular response to nerve growth factor stimulus
GO_0048538	Biological process	thymus development
GO_0048680	Biological process	positive regulation of axon regeneration
GO_0007173	Biological process	epidermal growth factor receptor signaling pathway
GO_0043149	Biological process	stress fiber assembly
GO_1900026	Biological process	positive regulation of substrate adhesion-dependent cell spreading
GO_0002318	Biological process	myeloid progenitor cell differentiation
GO_0006468	Biological process	protein phosphorylation
GO_0060323	Biological process	head morphogenesis
GO_0043524	Biological process	negative regulation of neuron apoptotic process
GO_0070374	Biological process	positive regulation of ERK1 and ERK2 cascade
GO_0043369	Biological process	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
GO_0043367	Biological process	CD4-positive, alpha-beta T cell differentiation
GO_0042127	Biological process	regulation of cell population proliferation
GO_0035019	Biological process	somatic stem cell population maintenance
GO_0098793	Cellular component	presynapse
GO_0005886	Cellular component	plasma membrane
GO_0005739	Cellular component	mitochondrion
GO_0043005	Cellular component	neuron projection
GO_0005829	Cellular component	cytosol
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0044297	Cellular component	cell body
GO_0005634	Cellular component	nucleus
GO_0031434	Molecular function	mitogen-activated protein kinase kinase binding
GO_0106310	Molecular function	protein serine kinase activity
GO_0044877	Molecular function	protein-containing complex binding
GO_0004708	Molecular function	MAP kinase kinase activity
GO_0004674	Molecular function	protein serine/threonine kinase activity
GO_0042802	Molecular function	identical protein binding
GO_0031267	Molecular function	small GTPase binding
GO_0004672	Molecular function	protein kinase activity
GO_0004709	Molecular function	MAP kinase kinase kinase activity
GO_0097110	Molecular function	scaffold protein binding
GO_0005524	Molecular function	ATP binding
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	BRAF
Protein name	V-raf murine sarcoma viral oncogene-like protein B1 (EC 2.7.11.1) Serine/threonine-protein kinase B-raf variant (EC 2.7.11.1) Uncharacterized protein BRAF B-Raf serine/threonine-protein non-specific serine/threonine protein kinase (EC 2.7.11.1) B-Raf proto-oncogene, serine/threonine kinase Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) BRAF protein B-Raf serine/threonine-protein (BRAF protein)
Synonyms	BRAF1 RAFB1
Description	FUNCTION: Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway . Phosphorylates PFKFB2 . May play a role in the postsynaptic responses of hippocampal neurons . .
Accessions	H7C4S5 ENST00000646891.2 ENST00000644969.2 P15056 A0A2R8Y8E0 E5FF37 H7C5K3 E2I6F4 ENST00000497784.2 H7C560 ENST00000642228.1 A0A2R8Y492 A0A2R8YDP5 Q75MQ8 A0A1X9T4I6 A0A0C4LC38 ENST00000647434.1 A0A2R8Y467 A0A2U3TZI2 F1CC75 ENST00000288602.11 ENST00000479537.6 A0A2R8YES9 ENST00000469930.2 ENST00000496384.7 A0A2R8Y679 ENST00000644650.1 ENST00000646730.1

BRAF report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review