MAP2K6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002931Biological processresponse to ischemia
GO_0051770Biological processpositive regulation of nitric-oxide synthase biosynthetic process
GO_0000165Biological processMAPK cascade
GO_0001649Biological processosteoblast differentiation
GO_0007165Biological processsignal transduction
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0060048Biological processcardiac muscle contraction
GO_0072709Biological processcellular response to sorbitol
GO_0051403Biological processstress-activated MAPK cascade
GO_0022602Biological processovulation cycle process
GO_1901796Biological processregulation of signal transduction by p53 class mediator
GO_0032308Biological processpositive regulation of prostaglandin secretion
GO_0006915Biological processapoptotic process
GO_0031098Biological processstress-activated protein kinase signaling cascade
GO_0090398Biological processcellular senescence
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0060348Biological processbone development
GO_0038066Biological processp38MAPK cascade
GO_0043065Biological processpositive regulation of apoptotic process
GO_0042770Biological processsignal transduction in response to DNA damage
GO_0051726Biological processregulation of cell cycle
GO_0035872Biological processnucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO_0120163Biological processnegative regulation of cold-induced thermogenesis
GO_0005856Cellular componentcytoskeleton
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0106310Molecular functionprotein serine kinase activity
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0004708Molecular functionMAP kinase kinase activity
GO_0019901Molecular functionprotein kinase binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMAP2K6
Protein nameDual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6) (EC 2.7.12.2) (MAPK/ERK kinase 6) (MEK 6) (Stress-activated protein kinase kinase 3) (SAPK kinase 3) (SAPKK-3) (SAPKK3)
Mitogen-activated protein kinase kinase 6
mitogen-activated protein kinase kinase (EC 2.7.12.2)
SynonymsMEK6
MKK6
hCG_28772
SKK3
PRKMK6
DescriptionFUNCTION: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction; and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases. .

AccessionsENST00000589295.5
P52564
K7ELM6
B5BU16
A0A0A0MRF7
A8K3Y2
ENST00000359094.7
ENST00000588110.5
ENST00000590474.7 [P52564-1]
K7EIW3
ENST00000589647.5 [P52564-2]