ZFP36 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032680Biological processregulation of tumor necrosis factor production
GO_0043488Biological processregulation of mRNA stability
GO_0006402Biological processmRNA catabolic process
GO_0051028Biological processmRNA transport
GO_0000165Biological processMAPK cascade
GO_0032703Biological processnegative regulation of interleukin-2 production
GO_0035278Biological processmiRNA-mediated gene silencing by inhibition of translation
GO_0045647Biological processnegative regulation of erythrocyte differentiation
GO_0071364Biological processcellular response to epidermal growth factor stimulus
GO_0060213Biological processpositive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO_1902037Biological processnegative regulation of hematopoietic stem cell differentiation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0061158Biological process3'-UTR-mediated mRNA destabilization
GO_0045616Biological processregulation of keratinocyte differentiation
GO_0042594Biological processresponse to starvation
GO_0031086Biological processnuclear-transcribed mRNA catabolic process, deadenylation-independent decay
GO_0097011Biological processcellular response to granulocyte macrophage colony-stimulating factor stimulus
GO_0060218Biological processhematopoietic stem cell differentiation
GO_0071356Biological processcellular response to tumor necrosis factor
GO_1900153Biological processpositive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO_1904582Biological processpositive regulation of intracellular mRNA localization
GO_0050728Biological processnegative regulation of inflammatory response
GO_0030099Biological processmyeloid cell differentiation
GO_0045600Biological processpositive regulation of fat cell differentiation
GO_0000289Biological processnuclear-transcribed mRNA poly(A) tail shortening
GO_0070935Biological process3'-UTR-mediated mRNA stabilization
GO_0071222Biological processcellular response to lipopolysaccharide
GO_1904246Biological processnegative regulation of polynucleotide adenylyltransferase activity
GO_0000288Biological processnuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO_0071385Biological processcellular response to glucocorticoid stimulus
GO_1902172Biological processregulation of keratinocyte apoptotic process
GO_0038066Biological processp38MAPK cascade
GO_1901835Biological processpositive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA
GO_0010837Biological processregulation of keratinocyte proliferation
GO_0009611Biological processresponse to wounding
GO_0044344Biological processcellular response to fibroblast growth factor stimulus
GO_0032897Biological processnegative regulation of viral transcription
GO_2000637Biological processpositive regulation of miRNA-mediated gene silencing
GO_0000178Cellular componentexosome (RNase complex)
GO_0000932Cellular componentP-body
GO_0030014Cellular componentCCR4-NOT complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_1990904Cellular componentribonucleoprotein complex
GO_0010494Cellular componentcytoplasmic stress granule
GO_0005634Cellular componentnucleus
GO_0070063Molecular functionRNA polymerase binding
GO_0003677Molecular functionDNA binding
GO_0019899Molecular functionenzyme binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0031072Molecular functionheat shock protein binding
GO_0019901Molecular functionprotein kinase binding
GO_0071889Molecular function14-3-3 protein binding
GO_0003729Molecular functionmRNA binding
GO_0035925Molecular functionmRNA 3'-UTR AU-rich region binding
GO_0046872Molecular functionmetal ion binding
GO_0003723Molecular functionRNA binding
GO_0019957Molecular functionC-C chemokine binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameZFP36
Protein namemRNA decay activator protein ZFP36 (G0/G1 switch regulatory protein 24) (Growth factor-inducible nuclear protein NUP475) (Tristetraprolin) (Zinc finger protein 36) (Zfp-36)
mRNA decay activator protein ZFP36 (Zinc finger protein 36)
ZFP36 ring finger protein
SynonymsG0S24
NUP475
hCG_43352
TIS11A
TTP
RNF162A
DescriptionFUNCTION: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis . Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery . Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation . Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs . Self regulates by destabilizing its own mRNA . Binds to 3'-UTR ARE of numerous mRNAs and of its own mRNA . Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF-alpha mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages (By similarity). Also plays a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response . Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia . Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA . Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA (By similarity). Associates also with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs . Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism; assists microRNA (miRNA) targeting ARE-containing mRNAs . May also play a role in the regulation of cytoplasmic mRNA decapping; enhances decapping of ARE-containing RNAs, in vitro . Involved in the delivery of target ARE-mRNAs to processing bodies (PBs) . In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing (By similarity). Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages (By similarity). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis . Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells . .; FUNCTION: (Microbial infection) Negatively regulates HTLV-1 TAX-dependent transactivation of viral long terminal repeat (LTR) promoter. .

FUNCTION: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs. .

AccessionsP26651
ENST00000597629.3
ENST00000594442.2
M0R252
M0QY76
ENST00000594045.2